Tapentadol Vs Hydrocodone- Is Nucynta Stronger Than Hydrocodone?

 

Tapentadol Vs Hydrocodone is one of the most sought-after comparisons prevalent in people with severe chronic pain. So, let us break down the key features of these two effective opioid analgesics. 

Tapentadol and Hydrocodone are opioid pain medications approved by FDA for treating moderate to severe chronic pain. Over a period of time, both analgesics have shown impeccable efficacy and benefits, making their comparison very common. 

This Tapentadol vs Hydrocodone comparative study is an extensive evaluation to answer the following question to help you choose the right opioid analgesic. 

• Is Nucynta stronger than Hydrocodone?
• Can I take Nucynta with Hydrocodone?
• Nucynta vs Hydrocodone-Which is the best suited for you? 

 

Tapentadol Vs Hydrocodone- An Overview

Tapentadol also known as the orange pain pill, is a centrally-acting analgesic with a dual mechanism of action helpful in treating acute and chronic pain. Nucynta is a popular tapentadol brand that shows similar effectiveness and uses as generic Tapentadol. 

Similarities And Differences

Even though Hydrocodone and Tapentadol are prescription opioid analgesics, a few characteristics set the two apart. Some frequently noted similarities and differences between Tapentadol and Hydrocodone are listed below [1,2]. 

 

 

Nucynta Vs Hydrocodone- Working Mechanism   

Hydrocodone- 

Following an oral administration, the Hydrocodone tablet is metabolized in the liver to form hydromorphone. The elimination is through the kidney. Clinical studies indicate hydromorphone to be responsible for the analgesic effect of Hydrocodone. The analgesic reaches the maximum serum concentration within one hour. 

Tapentadol (Nucynta)- 

The Tapentadol oral tablet is broken down in the liver and is eliminated through the kidney. It has 30 minutes of the onset of action and lasts for 5 to 6 hours. This analgesic has a dual mode of action and is effective in treating acute and chronic pain. 

Uses And Benefits 

 

 

Clinical uses and benefits of Hydrocodone 

• Hydrocodone is an effective treatment option for managing severe acute pain that does not often respond well to other medicines. It is, however, essential to note that Hydrocodone is not a PRN medication (administered as needed) and should be taken as prescribed by your physician.  
• It has an antitussive  (used for preventing or relieving a cough) property prescribed as a cough suppressant in adults [5]. 

Medical benefits of Tapentadol 

• The dual mechanism of action of Tapentadol makes it a much safer opioid choice in the market. With a low risk of abuse and dependency, Tapentadol can be used for long-term use. 
• It effectively treats acute pain following an injury, burn, or surgery. 
• Tapentadol is prescribed for chronic musculoskeletal pain. 
• The analgesic property of Tapentadol helps control diabetic neuropathy that requires round-the-clock pain relief. 

 

Tapentadol Vs Hydrocodone- Dosage & Administration 

Proper dosing and administration of a medication ensure the best benefits with lower risks of experiencing side effects. The basic information one must have before taking Tapentadol and Hydrocodone is listed below. 

 

Tapentadol is an oral pill that should be swallowed without being broken or crushed. It can be taken two to three times a day, depending on the cause and severity of your condition. Patients with a hepatic disorder should maintain 8 hours of gap between two dosages. The Tapentadol analgesic should not be abruptly discontinued, as it can cause withdrawal symptoms. Thus, the Tapentadol tapering-off method is recommended by physicians, which involves lowering the dose of the drug before completely halting its use. 

Hydrocodone Dosing and Administration Regimen-

The initial dose of Hydrocodone recommended for beginners is 5mg every 4 to 6 hours. It is advisable not to take more than 8 tablets a day. Based on the severity of the pain, the dose can be increased up to 10mg. 

The Hydrocodone combination medications are available as oral tablets, capsules, and syrups. They should be taken every 4 to 6 hours as prescribed by your physician.

Taking the medicine at the same time every day enhances its benefits. While administering the oral syrup, do not use a regular spoon to measure the dose. Instead, use a properly marked dropper. 

 

Drug Interaction- Can I Take Nucynta With Hydrocodone?

Drug Interaction is a reaction between two or more medicines or compounds when co-administered. It can lower the effectiveness and potency of the drugs and increase the risk of side effects. 

People often take Tapentadol (Nucynta) with Hydrocodone for a better analgesic effect; however, mixing Tapentadol and Hydrocodone can cause serious drug interaction [6]. 

Taking Tapentadol with Hydrocodone can cause central nervous system depression resulting in sedation, respiratory distress, and coma in severe cases. It may also increase the risk of hypotension (sudden drop in blood pressure). 

Hydrocodone can interact with 552 drugs, whereas, Tapentadol can interact with 372 medications. A few other medicines that should not be taken with Tapentadol and Hydrocodone are listed below. 

 

 

Nucynta vs Hydrocodone- Abuse Potential 

Long-term use of Hydrocodone can be a significant cause of addiction. It is a prescription drug found in over 200 commercial products [8]. 

 

The Hydrocodone addiction symptoms include constipation, anxiety, slower heart rate, weight loss, headache, fever, breathing issues, nasal congestion, and tightness in the chest. Most of these signs can be treated as a clue for the concerned people to understand what is happening. Suspected people with Hydrocodone abuse may further witness-

• Blurry vision resulting in the person's inability to walk, focus and bump into things and objects.
• It may result in confusion, affecting the person's ability to focus. 
• Signs of depression may appear as a lack of interest in socializing with friends and family. 
• If such people suffer from a seizure after taking the analgesic, it clearly shows Hydrocodone abuse [9]. 

The risk of Tapentadol addiction and abuse is low. A study indicates that Tapentadol is the least frequently abused opioid [10]. Another study confirms the low abuse risk of Tapentadol compared to other opioids due to its lower affinity for the mu-opioid receptor [11]. 

 

Three case studies conducted by a team of professionals showcase the ability of Tapentadol to cause addiction and dependency [12]. 

 

 

Case 1- A 20-year-old patient with 8 months of Tapentadol use and a history of substance abuse is seen to develop tolerance to Tapentadol within 1 month of use. 

 

Case 2- A 34-year-old man with nicotine and alcohol dependence experienced euphoria, hallucination, and a perception of time moving fast after taking Tapentadol 100mg. He developed cravings and tolerance within two months of use. Four years of Tapentadol use developed signs of dependency with no severe health risk. 

 

Case 3- A 30-year-old man taking Tapentadol 50mg for abdominal pain developed tolerance within 6 months. He also experienced a decrease in libido and erectile dysfunction. After 7 months of regular use, he noticed withdrawal signs such as body aches, fatigue, insomnia, and lack of self-confidence. 

 

Nucynta Vs Tapentadol- Which Is More Affordable? 

We would love a good deal while purchasing our prescription medications. When deciding between Nucynta and Tapentadol, the cost of the product often becomes a major deciding factor. 

According to the price listed on the website Drugs, the cost of Hydrocodone is $9.52 per pill [13]. On the contrary, the cost of Tapentadol 100mg online at Health Naturo is $2.7 per pill. 

The cost of Tapentadol and Hydrocodone may differ based on the pharmacy and pill package. 

 

Precaution And Warning

While taking Tapentadol and Hydrocodone, following the precautionary measures will lower the risk of side effects. 

• The use of Hydrocodone and Tapentadol can cause dizziness, sedation, and drowsiness, making it unsafe to operate heavy machinery and drive. 
• Taking alcohol with Tapentadol and Hydrocodone is not advised. It can increase the risk of experiencing dizziness and drowsiness. 
• The use of Hydrocodone with ibuprofen should be discontinued after 10 days of continuous use. 
• Tapentadol dose is not recommended for adults below 18 years of age. 
• Children and people below 18 years should take hydrocodone tablets or cough syrups after consulting a doctor. 
• People over 65 years should take the analgesic after consulting a doctor.
• The risk of addiction is higher in people with a history of abuse. 
• People with kidney, liver, and heart disorders should take Tapentadol and Hydrocodone dosage after consulting a doctor. 

 

Nucynta Vs Hydrocodone- Possible Side Effects 

Both Tapentadol and Hydrocodone can cause side effects; however, the severity of the adverse effect depends on the dose and the administration of the medication. Some of the notable side effects of Tapentadol and Hydrocodone are listed below. It is, however, important to note that this is not the complete list of all their possible health risks.