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Nucynta Reviews: A study on the long term effects of Tapentadol

Nucynta Reviews: A study on the long term effects of Tapentadol

Tapentadol pain medication is a popular opioid medication that is used for treating acute and chronic pain in people. Its dual mechanism of action makes it a much safer option in the market today thus leading to a potential rise in its non-prescription users. The use of Nucynta or also commonly known as Palexia 100mg is approved by FDA for short-term uses. However, it can be taken long-term under supervision. The incorrect dosing of the analgesic escalates the risk of side effects in the person. Thus, this article is a detailed study on the long-term use of Tapentadol opioid pain medication and its safety in users. 

Tapentadol long-term effects on the body 

Tapentadol is a centrally-acting analgesic that functions within 30 minutes of intake. This analgesic is a pro-drug which is not dependent on its metabolism to exhibiting its therapeutic action in the user. Thus, this makes Nucynta an alternative treatment for chronic pain that does not respond to other medications. Use of Tapentadol is advised to be taken for three weeks of continuous intake. Non-prescription users of the analgesic can take a break before continuing with its intake any further. The use of Tapentadol has a profound effect on the human brain and the CNS system. This thus largely impacts the physical and mental health of the person. 

Effect of long-term use of Tapentadol on the mental health [1]

The long-term use of Tapentadol can expand the chances of the users experiencing dependency and addiction. The euphoric effect of the analgesic is a major cause of its abuse in people. 

 Effect of long-term use of Tapentadol on the mental health

Apart from dependency, the other long-term effects of Nucynta on the mental health of the person are confusion, sleep disorders, anxiety, restlessness, irritability, etc. If you wish to buy Tapentadol for long-term use you should consult a doctor. Studies and Nucynta reviews indicate that prescription use of Tapentadol is safe and does not show severe side effects and dependency in the user. 


Table 1: Long-term effect of Tapentadol on the physical health 



Effect of Nucynta 



Nausea and Vomiting

Very common (10% or more)


Impaired gastric emptying

Rare (less than 0.1%)


abdominal discomfort, dry mouth

Common (1 to 10%)

Respiratory system

Cough, respiratory depression, 

Uncommon (0.1% to 1%)


Upper respiratory tract infection

Common (1 to 10%)


involuntary muscle contractions, muscle spasms

Common (1% to 10%)


Bone pain

Uncommon (0.1% to 1%)

Ocular system 

Blurry vision 

Common (1% to 10%)


Any form of visual disturbance

Uncommon (0.1% to 1%)

Metabolic activity

Decrease in appetite 

Common (1% to 10%)

Nervous system


Very common (about 24%)



Common (about 15%)


Sedation, disturbance in attention

Common (1% to 10%)


Memory impairment, confusion, balance disorder

Uncommon (0.1% to 1%)


Coordination issues

Rare (less than 0.1%)


Does Tapentadol affect the liver?

The acute or long-term use of Tapentadol 100 mg can cause dose-dependent oxidation of protein in the liver. A study by Joana Barbosa et al states that the use of Nucynta can lead to causing hepatotoxicity in the user.

Does long-term use of Tapentadol affect blood sugar?

There are no studies indicating the effects of Nucynta on the blood sugar level of the person. However, scientific reports show that the use of Nucynta ER is an effective solution for managing painful diabetic neuropathy in patients [3]. This is a very common condition and affects one-third of all diabetic people in the world. 

The effect of Tapentadol on anxiety

Anxiety is a noted side effect of Tapentadol. In fact, according to the website drugs, about ten percent of the users taking Tapentadol suffer from anxiety. A study by Ulderico Freo et al expresses that the use of Nucynta assists in lowering HADS (Hospital Anxiety and Depression Scale) anxiety in the patient [4]. However, one should take the Tapentadol dose for anxiety only under the supervision of a physician. 

Can long-term use of Tapentadol cause depression?

The use of Tapentadol for a longer period than the one prescribed can cause adrenal gland problems thus leading to causing adrenal depletion in the body [5]. This can affect the mental health of the person and cause depression and mood swings in the user. 

Clinical evidence- Safety of long-term use of Nucynta 

A study by James E. Wild MD et al, on Tapentadol vs Oxycodone, was done to study the effects of long-term safety and tolerability of Tapentadol ER in chronic pain patients [6]. 

Tapentadol vs Oxycodone

This study indicates that the use of Tapentadol ER 100mg projected better gastrointestinal tolerability compared to Oxycodone. It helped in managing chronic pain in patients for 1 year with no potential side effects for the user. 

How long should you take Tapentadol?

The prescription use of Nucynta is for three continuous weeks. It is important to take a break after 21 days to avoid dependency. Users with severe chronic pain can either continue with the dose after the interval or consult a physician for long-term use. 

What happens to the body when you take Tapentadol?

Upon ingestion, the analgesic works directly on the opioid receptor of the central nervous system of the body. The mechanism of action includes interrupting the nerve signals between the brain and the affected part of the body. Thus helping get relief from pain within 30 minutes of administration of the opioid medication. 

How often should you take Tapentadol?

The maximum dose of Tapentadol is 500mg for adults in a day. It is available in two formulations and has different strengths. The number of doses and the strength depends on the severity and the cause of the pain. The use of Tapentadol ER (extended-release) has an extensive action and can be taken twice a day. On the other hand, the action of the Tapentadol IR lasts for 5 to 6 hours in the people and can be taken 4 to 5 days a day. 

Can you cut Nucynta in half?

The Tapentadol (Nucynta) tablets should be taken as a whole. It should not be broken or crushed before taking the analgesic. Such practices can induce the quick release of the medication further resulting in side effects for the user. 

Long term side effects of Tapentadol 

Tapentadol uses a dual antagonist action that makes it less prone to causing side effects in people. Overdosing and improper administration of opioid medication is a key factor responsible for causing adverse effects in the user. Some of the side effects of Tapentadol pain medication are constipation, nausea, vomiting, dizziness, sweating, etc. 

How long do Tapentadol side effects last?

The half-life of Tapentadol is 4 hours and its action lasts for 5 to 6 hours. Therefore, the side effects of the opioid analgesic stay for a maximum of 4 to 6 hours in the patient. The side effects of Nucynta are mild and do not require much medical attention. People experiencing any of these signs are recommended to cease the use of pain medication. If the discomfort persists one should get immediate medical assistance. 

Can Tapentadol cause weight gain? 

Suffering from a loss of appetite is believed to be one of the withdrawal signs of Tapentadol [7]. Thus, it does not aid in causing weight gain. 

Can Nucynta cause high blood pressure? 

The use of Nucynta (Tapentadol) with other medications such as isocarboxazid, phenelzine, tranylcypromine, selegiline, or rasagiline can cause an increase in the blood pressure in the user. Therefore if you have taken any of these pills in the last 14 days of administering the Nucynta dose it is recommended to first consult a physician [8]. 

Can Long term use of Nucynta cause withdrawal? 

Sudden and abrupt discontinuation of the Tapentadol opioid pain medication after long-term use can cause withdrawal signs in the user. These symptoms may begin to appear within a few hours of the last dose. Therefore it is crucial for one to gradually lower the dose of the analgesic before completely discontinuing the use of the pain medication. This “tapering off” method is incorporated by most physicians before the termination of the treatment. 

What are the withdrawal symptoms of Tapentadol? 


withdrawal symptoms of Tapentadol

The common long-term Nucynta withdrawal symptoms in users are sweating, anxiety, nausea, upper respiratory issue, insomnia, sweating, etc. 

Can you build a tolerance to Tapentadol?

Long-term use of Tapentadol can cause tolerance thus gradually losing its efficacy in the user. In such cases, the patient has to keep changing and increasing the dose of the drug for effective results. It is, therefore, best for a person to take the analgesia for a short period. 

Nucynta Reviews - A testimonial (ratings) on its long-term uses

The Nucynta reviews help one get a better insight into the effectiveness, ease, and experience of the user of the analgesic. The overall rating of Nucynta on WebMD is 3.3 out of 5 whereas, at it is 6.2 out of 10. However, here is a list of Nucynta user reviews for long-term use of the analgesic highlighting its potency and side effects. 


Table 2: Nucynta reviews its long-term use side effects 

Prescription use

Side effect experienced 


Dosage duration

Date of review



Mild constipation 


5 to 10 years 



Chronic neck pain/ migraines

dizziness, blurred vision, dry mouth, euphoria. Nothing too bad.

Chronic neck pain/ migraines

1st day 



Fibromyalgia, Dysplasia, and arthritis

No issues reported

Fibromyalgia, Dysplasia and arthritis

6 years 




No issues reported


2 to 5 years 



Bursitis and fibromyalgia

No issues reported

Bursitis and fibromyalgia

5 years 



DDD with Radiculopathy

Stomach pain

DDD with Radiculopathy

8 months



General body pain

Dry mouth 

General body pain

Less than a month 



Scoliosis, fibromyalgia, and RA

No issues reported

Scoliosis, fibromyalgia and RA

3 years 





  1. Tapentadol Side Effects, drugs
  2. Acute administration of tramadol and tapentadol at effective analgesic and maximum tolerated doses causes hepato- and nephrotoxic effects in Wistar rats, Joana Barbosa et al, Pubmed 

  3. Tapentadol extended-release in the management of peripheral diabetic neuropathic pain, Nalini Vadivelu et al,
  4. Effects of tapentadol on pain, motor symptoms and cognitive functions in Parkinson’s disease, Ulderico Freo et al,

  5. Tapentadol (Oral Route), Mayoclinic
  6. Long-term Safety and Tolerability of Tapentadol Extended-Release for the Management of Chronic Low Back Pain or Osteoarthritis Pain, James E. Wild MD, online library 
  7. Palexia 50 mg film-coated tablets,
  8. Tapentadol Tablets, drugs