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Buy Tapentadol online

Brand Name Tapentadol
Generic Name Nucynta
Manufacturer Cadila Pharmaceuticals Ltd
Active compound Cellulose, Microcrystalline, Magnesium stearate, Silica colloidal anhydrous
Indication Oral pill
Form Tablet
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Tapentadol Hydrocholoride - Cadila pharma

Tapentadol is a centrally acting analgesic used to treat moderate to severe pain in people. It is manufactured and marketed by Cadila Pharmaceuticals Ltd. Nucynta; the brand name for Tapentadol is an FDA-approved prescription medication recognized in clinical practice to help with both acute and chronic pain. This opioid pain reliever belongs to the class of piperidine chemical compounds and is prescribed alone or in conjugation with other medication for best results. The high tolerability and safety profile of Tapentadol makes it one of the most widely used opioid medications on the market. You can now Buy Tapentadol online with customer-friendly features with just three clicks. Avail extra savings on purchases with our regular offers and discounts.

Composition of Tapentadol

Tapentadol tablets is biconvex, round, and film-coated. The 100mg pill is orange in color with "O-M" on one side and "100" on the other side. Each tablet is a formulation of the following compounds.

 

Active Compound

Tapentadol Hydrochloride

100mg

List of excipients

Microcrystalline Cellulose 

10mg

Colloidal Silicon Dioxide

1.5mg

Povidone K 30 USP

12mg

Croscarmellose sodium

15mg

Polyvinylpyrrolidone

4.5mg

Magnesium Stearate

3mg

Coating

Ethylcellulose Aqueous Dispersion

15mg

Polyethylene Glycol

5mg

Polyvinylpyrrolidone

2mg

Brand names-

The popular brand names of Tapentadol are Nucynta, Nucynta ER, Aspadol, Palexia, etc. However, different countries might have other trade names for this opioid analgesic.

Tapentadol Indications and Usage

The use of an opioid such as Tapentadol is one of the pharmacological foundations for treating acute and chronic pain. The prescription use of the analgesic is for treating pain arising from post-surgery, psychogenic pain, Arthritis, and severe injuries. Depending on the cause and the severity of the pain, a physician can prescribe Tapenatdol as monotherapy or concomitantly with other medications.

 

Clinical study on Tapentadol validated by the FDA

Efficacy of Tapenatdol for post-operative pain:

Patients between the age of 18 to 80 years suffering from moderate to severe pain following an orthopedic surgery were given Tapentadol 50mg, 75mg, and 100mg. The study indicates that every patient achieved a 50 percent reduction in pain within a few minutes of intake, with no evident side effects.

 

How does it work?

Tapentadol is a dual-acting analgesic with a low affinity for the mu-opioid receptor. It is the first US FDA-approved analgesic with both opioid receptor agonist and noradrenaline reuptake inhibition activity. This dual mechanism of action makes Tapentadol an effective solution in the treatment of neuropathic pain. According to a research paper by Polati. E.et.al, the Tapentadol pain medicine is suggested to be the first agent of a new class of drug.

Absorption

The mean bioavailability after administration of a single dose of the analgesic is approximately 32%. The maximum serum concentration of the pain medication is 1.25 hours after dosing. A study on multiple doses shows a mean accumulation factor of 1.6 for the generic drug and 1.8 for its metabolite. This factor depends on the half-life and dosing interval of the analgesic.

Effect of Food on metabolism

The intake of food rich in fat and calories with Tapentadol can increase the Cmax (maximum serum concentration that a drug achieves) by 16%.

Elimination

The metabolism of Tapentadol is extensive. About 97% of the generic compound metabolizes in the body. Following an oral administration, the elimination of about 70% of the dose is through the urine. The average terminal half-life is 4 hours.

Tapentadol Dosage

The Tapentadol medication is available in the form of oral tablets of different strengths. The standard dose is Tapentadol 100mg; however, it should be individualized based on-

  • The severity of the pain
  • Ability to monitor the patient
  • Prior experiences with similar medications.
  • Risk factors for abuse
  • The response of the patient to the medication.

The other available dosages of Tapentadol available in the market are 50mg and 75mg, which should be taken every 4 to 6 hours. On the first day, administer the second dose of Tapentadol after one hour of taking the first dosage. The maximum dose of the analgesic on the first day is 700mg and 600mg on the subsequent days.

Extended-Release formulation (Tapentadol ER)

The extended-release or the Prolong release formula of Tapentadol exerts similar effects to the generic version (Tapentadol IR). Switching from immediate-release to extended-release is permissible if taken in equivalent daily doses.

Several reports suggest that short-term (about 15 weeks) use of Tapentadol ER twice a day can provide better relief from pain. Clinical studies do not suggest the development of tolerance in long-term use (up to 24 months).

The half-life of Tapentadol ER is 24 hours and it can be administered twice a day at an interval of 12 hours.

Key advantages

  • High gastrointestinal tolerability
  • Lower risk of nausea, vomiting, and constipation
  • Broad spectrum of efficacy

Nucynta discontinuation

Do not abruptly stop the intake of the medication. Users should first reduce the intake of the dose initially by 25 percent and gradually to 50 percent before completely discontinuing the medication.

 

Storage of Tapentadol pills

  • Store the medicine in a clean, dry place at room temperature.
  • Avoid direct exposure to sunlight.
  • Always keep medications out of reach from children.

Directions for Use

  • The long-term use of Tapentadol is not advisable. Discontinue the use of the analgesic after three weeks of continuous use.
  • Take it orally with plain water.
  • Breaking, snorting, chewing, and crushing the pill can cause potential health risks.
  • The administration of Tapentadol is not advised for older people as they have compromised hepatic and renal functioning.
  • Patients with the hepatic disorder should maintain 8 hours of gap between doses.

Warnings & Precautions

Tapentadol has been a treatment choice for chronic pain since 2009. Along with its exceptional analgesic potency, improvement of functionality, and quality of life, it showcases a high tolerability and safety profile in users. However, conditions such as overdoing, improper administration, and other health disorders may increase the risk of experiencing side effects. Therefore, exercising additional vigilance while taking the analgesic is essential.

  • A pregnant and breastfeeding mother should only take the Tapentadol dosage after consulting their physician. Animal studies show evidence of maternal and embryofetal toxicity. The finding of the same studies shows a reduction in fetal viability and skeletal delays along with additional variations.
  • Tapentadol use is not recommended for women during or immediately prior to labor and delivery. Monitor the infants for respiratory depression whose mother has taken Tapentadol.
  • Pharmacodynamic and Physicochemical toxicological analysis on Tapentadol indicate the presence of the compound in the breast milk of the mother. Therefore, the use of the analgesic is not advisable for nursing mothers.
  • The intake of Tapentadol in users with impaired hepatic functioning can result in higher exposure and serum level of the compound.
  • Tapentadol, when taken with alcohol, elevates the risk of side effects, including developing tolerance in the user.

Contradictions

  • Impaired Pulmonary Function- The administration of Tapentadol is contradictory in patients with respiratory depression. The use of the analgesic is also warned in people with acute or severe bronchial asthma.
  • Paralytic Ileus- This condition paralyzes the muscle responsible for the food movement through the intestine. Such patients are not advisable to take Tapenatdol without a prescription.
  • Monoamine Oxidase Inhibitors- The ingestion of Tapentadol is contradicted in people who are under monoamine oxidase (MAO) inhibitor treatment or have taken it in the last 14 days. This can potentially escalate the level of norepinephrine thus resulting in cardiovascular disorder.

Tapentadol side effects listed by FDA 

Two prominent Tapentadol treatment-emergent adverse effects identified by the FDA are respiratory and CNS depression. 

Effects 

Symptoms 

Cardiac disorders

Increase or decrease in heart rate. 

Gastrointestinal disorders

Abdominal discomfort.

Immune system disorders

Hypersensitivity.

Musculoskeletal and connective tissue disorders

Sensation of heaviness, Involuntary muscle contractions.

Nervous system disorders

Headache, lack of attention span, memory impairment, Sedation.

Psychiatric disorders

Agitation, euphoric mood, restlessness, nervousness, abnormal thinking, disorientation.

Renal and urinary disorders

Urinary hesitation, Pollakiuria.

Vascular disorders

Decrease in blood pressure. 

Skin disorder 

Urticaria.

 

Drug interactions

With numerous medicines available online, the possibility of drug interaction is more today, than ever before. Such interactions can lower the efficacy of the drug along with causing unexpected adverse effects. A user taking Tapentadol should be well-informed of the possible health risk of the analgesic.

 

Interaction with other medicines

Minor interaction

Severe Interaction

Symbicort

Cymbalta

Ventolin

Endep (amitriptyline)

Esomeprazole

Pregabalin

Paracetamol

OxyContin

 

Valium

Interaction with health disorders 

seizure disorders

Hypotension

Biliary spasm

Prematurity

Urinary retention

Intracranial pressure

 

Liver disorder

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FAQ's


The analgesic effects of Tapentadol pain medication can be seen in 30 minutes of taking the dosage.

The Tapentadol drug stays in the system for about 22 hours. Several factors influence the action and how long the medication stays in your system after the last dose. Factors such as body mass, metabolic rate, overall health, age, dosage, and tolerance contribute to the efficacy of the medication in the body. 

Studies published by David Biondi et.al, shows that Tapentadol demonstrates better and higher potency for treating body pain over Oxycodone IR. Many other studies are emphasizing the same establishing Tapentadol to be a better analgesic.

Tapentadol belongs to the class of opioid analgesic and is categorized as Narcotic. It works by altering the response of the nervous system and the brain towards pain. 

Tapentadol does show up in a drug screening test. The medication is seen to stay in the urine for 3 to 4 days. It is not detected in the blood after 24 hours of the last dosage. However, the drug stays in the hair for a longer period of time. Drug tests done on your hair can show traces of Tapentadol for about 90 days from your last dose. 

Tapentadol is a prescription medication and is not available over the counter. However, you do not require any prescription to buy Tapentadol online from HealthNaturo.

Tapentadol for children is not yet approved. People under 18 years should not take it without a prescription.

Tapentadol and Tramadol are both opioid medicines with contrasting working mechanisms and attributes. According to DEA categorization, Tapentadol is schedule II whereas Tramadol is schedule IV. Moreover, Tapentadol has dual properties of norepinephrine reuptake inhibition and mu agonist, unlike Tramadol. Therefore comparative studies on Tapentadol vs. Tramadol shows the former is a more potent analgesic.

Yes, Tapentadol can make you feel sleepy. It is one of the most prevalent repercussions of this opioid medicine.

Take Tapentadol 3 to 4 times daily. However, patients can alter the dose based on the pain intensity with suggestions from a physician.

Tapentadol can impart a euphoric sensation as it impacts the brain's pain perception. Also, note that it can make you feel high even if you follow the prescribed dosing information.

It is advisable to complete the prescribed dosage course and follow the tapering-off method (deliberately reduce the dosage).

Using Tapentadol for a prolonged span can result in being habitual or addictive. Therefore take the opioid medicine only for the prescribed duration.

Safe driving and heavy machinery operation require alertness and quick responsiveness. As Tapentadol can make you sleepy, it is advisable first to let the effects of the medicine subside and then proceed with these activities.

It is pivotal to strictly adhere to the prescribed Tapentadol dosage as erroneous intake can lead to adverse impacts and life hazards.