Aspadol 100mg (Tapentadol)

 

What are Aspadol 100mg Tablets? 

Aspadol is a novel centrally acting analgesic with an improved safety profile than other opioid pain medications. It is the brand name of Tapentadol, a compound first synthesized in the USA and marketed by Janssen Pharmaceuticals. 

It is a strong analgesic prescribed for treating acute and chronic pain within 30 minutes of administration. 

Aspadol 100mg Uses    

Aspadol (Tapentadol) provides relief from acute and moderate pain associated with injury, diabetic neuropathy, chronic musculoskeletal pain, back pain, toothache, rheumatoid arthritis, and headaches. 

It is prescribed to manage short-term acute pain in adults weighing at least 88 pounds (40 kg) when other non-opioid pain medications fail to provide effective relief from pain. 

Further, several research publications scientifically establish the therapeutic use of Aspadol for cancer pain management, postoperative pain, and osteoarthritis. 

Benefits Of Aspadol 100mg Tablets

Aspadol 100 tablets are prescribed when a round-the-clock analgesic effect is needed. It offers several clinical benefits over other analgesics, such as:  

• It is available in various dosage forms, such as Immediate Release (IR) tablets and Extended-release (ER) tablets, that allow tailored pain management based on individual medical needs. 

• It has a quicker onset of action and begins to work within 30 minutes of administration. It has a therapeutic action time of 4 to 6 hours and 12 hours for Aspadol ER tablets. 

• The FDA approves using Tapentadol as the first analgesic with a dual mechanism of action. 

• It is two to three times more potent than Tramadol, as per a 2021 study by Lucien Roulet et al. 

• It has an improved tolerability profile; thus, common side effects such as vomiting and gastrointestinal motility are reduced with Aspadol. 

How Does Aspadol Work?

Aspasol (Tapentadol) is a single-molecule compound that can deliver analgesia through two distinct mechanisms, differentiating it from other pain medications. 

The mu-opioid receptor agonist activity of Tapentadol and its ability to inhibit Noradrenaline re-uptake comprise the two modes of Tapentadol’s mechanism of action. Both mechanisms of action contribute to its analgesic effect.

It works by binding to the mu-opioid receptor in the brain and blocking the transmission of pain signals, thus lowering the feeling of pain. 

The Metabolism And Elimination Of Aspadol Tablets

• It is metabolized in the liver to Tapentadol-O-Glucuronide as a major metabolite. 

• It follows a first-order elimination by the kidney with a total clearance rate of 1530±177 ml/min. 

Aspadol 100 mg Dosage Guidelines 

The intake of Aspadol 100mg tablets is effective for all its approved medical conditions. The maximum dosage and dosage interval are listed below in the table, depending on the formulation. 

 

 

On the first day of the treatment, a second dose of Aspadol IR can be taken after 1 hour of taking the first dose. 

Aspadol 100mg dose Conversion From IR To ER- 

The conversion of Aspadol IR to ER should be done through a direct milligram-to-milligram conversion on a total daily dose basis. 

Missed Dosage-

If you forget to take your dosage, take it as soon as you remember. If it is almost time for the next dosage, you can skip the missed dosage and continue with the next dose at its scheduled time. 

Never take a double dose to make up for the missed dose. 

Overdosing On Aspadol Tablets-

Taking a high dose of tapentadol can result in overdosing, causing serious health issues. Some notable symptoms of overdose include blurred vision, drowsiness, slowed breathing, confusion, clammy skin, sweating, muscle weakness, and shallow breathing. 

Larger doses can also cause respiratory depression, which, if left untreated, can damage parts of the brain. 

How To Use Aspadol 100mg?

• Swallow the Aspadol 100mg tablet with water without breaking or crushing it. 

• It can be taken with or without food. However, people with nausea should take it after a meal. 

• Taking it at a fixed time regularly enhances the efficacy of the treatment. 

• Discontinuation of the treatment should be done under the supervision of a doctor. Sudden termination of Tapentadol intake may cause withdrawal symptoms such as-

  • Teary Eyes.

  • Restlessness.

  • Yawning.

  • Irritability.

  • Sweating.

  • Anxiety.

  • Difficulty falling asleep.

  • Nausea.

  • Shivering.

  • Fast breathing.

  • Palpitation.

  • Widening of the pupils.

  • Weakness.

  • Runny nose.

  • Stomach cramps.

  • Muscle, back, or joint pain

  • Loss of appetite.

  • Hallucinations. 

Duration of Treatment

• Aspadol 100 mg is not prescribed for more than a few days. However, the treatment duration is evaluated based on the severity and cause of the condition. 

• For pediatric patients, the use of an Aspadol tablet is not advisable without a doctor’s consultation. 

Side Effects of Aspadol 100mg

The common side effects of Aspadol are vomiting, dizziness, nausea, constipation, pruritis, somnolence, and headache. The other side effects include dry mouth, excessive tiredness, stomach pain, heartburn, and abnormal dreams.

Get Immediate Medical Attention Or Call 911 Right Away If You Experience The Following Symptoms. 

• Rash.

• Hives.

• Chest pain.

• Feeling lightheaded.

• Irregular menstruation.

Aspadol 100mg Drug Interactions

A drug interaction may decrease, delay, or change how a medication works. It occurs when another supplement, medicine, or food item affects the mechanism of action of Tapentadol.  

Tapentadol can cause 184 major drug interactions, 190 moderate drug interactions, and 1 minor drug interaction, as listed below. 

• The major drug interactions include amoxapine, bupropion, baclofen, chlorpromazine, codeine, cyclobenzaprine, ergotamine, fluphenazine, gabapentin, hydromorphone, hydrocodone, methocarbamol, oxymorphone, pregabalin, rasagiline, and tizanidine. 

• The intake of medications such as atropine, clonidine, epinephrine, ginkgo, ketamine, levocetirizine, midazolam, methoxamine, naloxone, norepinephrine, naphazoline nasal, phenylephrine, solriamfetol, terbutaline, and ziconotide can cause moderate drug interactions. 

• Whereas the only medication known to cause a minor interaction with Tapentadol is evening primrose. 

• The intake of Aspadol ER with other opioid medications, central nervous system depressants, and benzodiazepines can cause breathing problems, serious drowsiness, and coma. 

To avoid such drug interactions, inform your doctor of all the medications and supplements you take. 

Storage and Disposal 

• Keep the tablets in their original pack.

• Due to the risks associated with accidental ingestion and misuse, store the tablets away from the sight and reach of children. 

• Store the pills at 20°C to 25°C (68°F to 77°F), away from moisture and heat. 

• Expired and unwanted tablets can be disposed of by wrapping the medicine on a piece of paper before flushing it down the toilet. 

Precautions and Special Considerations for Taking Aspadol 100mg

• Before taking Aspadol tablets, inform your physician if you have a history of seizures, mental health disorders, or thyroid, liver, or kidney issues. 

• Its use during pregnancy is not advisable, as prolonged use during pregnancy can result in withdrawal symptoms in the newborn baby. 

• Breastfeeding while on treatment is not considered safe for the infant as it may pass into the breast milk. 

• Tapentadol use may decrease fertility in men.

• It may cause drowsiness; thus, driving a car or operating any heavy machinery is considered unsafe.  

• This analgesic worsens symptoms of constipation in people with existing bowel problems. Consult a doctor for dietary changes and safe laxative options to prevent constipation from Tapentadol. 

• Patients should not consume alcohol or use products containing alcohol while taking Tapentadol pain medicines. The co-ingestion can result in an increase in the plasma concentration of Tapentadol, leading to overdose symptoms. 

• Its use by people under the age of 17 and above 65 years should be done under the supervision of a medical professional. 

Contraindications-

Tapentadol is contraindicated in patients with the following health conditions. 

• Acute bronchial asthma.

• Significant respiratory depression.

• Hypersensitivity to Tapentadol.

• With gastrointestinal obstruction. 

• Use of monoamine oxidase inhibitors (MAOIs) in the last 14 days.

Special Considerations-

It may be habit-forming if used for a long period. Misuse of Aspadol can exacerbate certain side effects, including Nausea, Dizziness, Drowsiness, Vomiting, and Constipation. 

Thus, it should be used only as prescribed by your healthcare provider. 

Aspadol Use Limitations-

Do not take Tapentadol with the following medical conditions. 

• Patients with severe lung problems, asthma, or breathing troubles 

• In cases of bowel blockage or narrowing of the intestines or stomach.

Healthnaturo’s Approach To Affordable Aspadol Pills 

HealthNaturo offers affordable Aspadol 100mg tablets by sourcing them directly from the manufacturer, thus eliminating the need for intermediaries. It ensures cost-effectiveness and guarantees the utmost quality of the medicines. 

Our commitment to maintaining these standards is a testament to our dedication to delivering affordable, high-quality medications. 

Aspadol 100mg Price At Healthnaturo-

Healthnaturo takes pride in providing genuine and affordable Aspadol 100 mg tablets. 

At Healthnaturo, we understand that our customers may have different pricing preferences.

Thus, we offer two distinct pricing and delivery options for Aspadol 100mg tablets. 

• Overseas Pricing- It is available to all, including U.S. residents. Here, the medication is shipped from our facility in India, offering cost savings and affordability. However, with overseas shipping, the delivery time may be longer. 

• US-to-US Pricing- We offer US-to-US shipping options for customers who prioritize quick delivery within the United States. Our warehouse in the USA enables us to offer USPS express shipping and delivery in just 3 days in the United States. 

Regular Price Of Aspadol 100mg - Popular online pharmacies in the USA offer 180 tablets at $538.20 ($2.98 per pill) and 200 tablets at $598.00 ($2.99 per pill). 

 

Discounted Price Of Aspadol 100mg Price At Healthnaturo - The cost of Aspadol 100mg for 180 pills is $500 ($2.77 per pill) for US to US express delivery. Whereas for overseas shipping, the price is $304 for a pill package of 200 tablets ($1.52 per pill).  

 

Total Savings - At Healthnaturo, you can save up to $1.47 per pill with our overseas shipping option and about $0.21 per pill with our US-to-US delivery option. 

Key Customer Benefits At Healthnaturo

• Free shipping on all orders 

• Hassle-free return and refund policy 

• Express shipping is available across the USA. 

• Loyalty benefits all reorders. 

• Safe payment gateways through all credit and debit cards 

• 24x7 customer service.

Contact Us For More Information And Discount Offers

Get in touch with our customer support team at [email protected] for more information about Tapentadol, including usage, dosage, and potential side effects.

Our dedicated team will guide you through all our latest offers and how to avail of them.