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Soma Working Mechanism And Dosage Guidelines

Soma Working Mechanism And Dosage Guidelines


The Carisoprodol mechanism of action includes its metabolism in the liver and excretion as urine by the kidneys. With a half-life of 4 hours, it stays in the system for 8 hours and begins and has a 30 minutes onset of action. 

The Soma 350 mg is recommended for beginners and can be taken 3 to 4 times a day, whereas the 500 mg dosage of the Soma pill can be administered 2 to 3 times daily. 



Staying informed about the mechanism of action of the Soma pill and its dosage guidelines is very important as it can help avoid possible drug interactions, increase the effectiveness of the treatment, and lower the possibility of experiencing side effects. 

Soma is a muscle relaxer developed during the 1950s. However, the drug got approval from the FDA in 1959 and has been on the market since then. It is the brand name of Carisoprodol and works within 30 minutes of intake. 

This blog looks deeper into how the Soma pill works, along with laying down the basic guidelines for its dosage regimen. 


How Does Soma Work? 

Soma pill, also known as the Soma 111 pill, is a centrally acting skeletal muscle relaxant that does not directly relax the skeletal muscle. Its analgesic effect is associated with altered interneuronal activity in the spinal cord and the brain. In simpler words, it prevents the pain signals from reaching the brain's GABA receptors (Gamma-aminobutyric acid), that is responsible for maintaining the neurotransmitter of the Central Nevous System (CNS). 


Carisoprodol is metabolized in the liver with the help of cytochrome enzyme CYP2C19 to form meprobamate which has both sedative and anxiolytic properties. 

Half-life of Soma pill- 

The average half-life of Soma pill or Carisoprodol is around 2 hours, which represents the time taken by the medication to reduce to half. 

The half-life of Meprobamate is 10 hours, which indicates that it takes about 2 days for the body to eliminate it, as shown in the table below. 


Drug Level Remaining 

Time (Carisoprodol)

Time (Meprobamate)

100 %

0.00 hrs

0.00 hrs

50 %

2.00 hrs

10.00 hrs

25 %

4.00 hrs

20.00 hrs

12 %

6.00 hrs

1.25 days

6.25 %

8.00 hrs

1.67 days

3.13 %

10.00 hrs

2.08 days



The Soma pill has a rapid onset of action and works within 30 minutes of intake. With its effects lasting up to 5 to 6 hours. 

Route of Elimination-

The Soma pill is eliminated through the kidneys as urine following renal elimination. 


Soma Dosage Guide



The Soma 350 mg is recommended for beginners and should be taken three times in the morning and once before bed. In comparison, the 500 mg dose of the Soma pill is recommended for people who are suffering from severe pain and do not respond well to the lower dosage of the muscle relaxant. The Soma 500 mg pill should be taken 2 to 3 times a day. 


The max dose of soma is 1500 mg in a day, and taking a higher dose can result in overdosing. A few symptoms of Soma overdose include Mental confusion, Fainting, Lightheadedness, Shallow breathing, and Rapid heartbeat. 

Soma pill, when taken with other central nervous system depressants, increases the risk of overdosing. 

To avoid a Soma overdose, one should follow the dosage and administration guidelines given by your doctor. 


Soma Dosage Restrictions 

The intake of the Soma pill is restricted in the following people-

  • Pregnant and lactating women. 

  • Elderly people above the age of 65 years

  • People with a history of kidney, liver, and a heart disorder. 

  •  Children below the age of 17 years. 

  • Consult a doctor before administering any other medication or supplements with the Soma pill to avoid any possible drug interaction. 


Our Final Thoughts On Soma's Mechanism Of Action And Dosage 

The Soma muscle relaxer works within 30 minutes of intake through metabolism in the liver. With a half-life of 2 hours, Carisoprodol or the Soma pill stays in the system for 8 hours. 

The effectiveness of muscle relaxant lasts for 5 to 6 hours, and to maintain its effectiveness all through the day, its dosage must be taken 3 to 4 times a day.


Carisoprodol, the active compound of the Soma pill, works by preventing the transmission of pain signals from reaching the receptor of the brain.

The Soma pill works on the GABA (Gamma-aminobutyric acid) receptor of the brain, which is responsible for being the primary neurotransmitter for the central nervous system (CNS).

The Soma pill takes around 30 minutes to work.

in 24 hours, Soma 350 mg can be taken 3 to 4 times, whereas the 500 mg pill can be taken only 2 to 3 times.

The Soma 500 mg is the strongest strength of mg of the muscle relaxer.


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  5. Important considerations for taking carisoprodol,
  6. How Long Does Soma (Carisoprodol) Stay in Your System?