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How long does Soma stay in the system?

How long does Soma stay in the system?


The body takes about 11 hours to eliminate Soma from the body. How long Soma stays in the system is determined by their half-life (1 to 3 hours) and may often vary in people. Carisoprodol may be detected in Soma drug tests if conducted before the muscle relaxer is eliminated. 



How long does Soma stay in your system is one question most Carisoprodol users often wonder as it determines the effectiveness of the muscle relaxer and its detection in drug tests. 

Soma pill is a prescription medication for treating short-term acute pain in users. The analgesic is very effective and can treat severe lower back pain in addition to other causes of acute pain. Carisoprodol targets the body's central nervous system and prevents pain stimulation from reaching the brain receptors. 

This exhaustive blog determines how long Soma stays in your system and how Soma drug tests can detect the presence of Carisoprodol in the body. 


How Long Does The Body Take To Eliminate Soma?




How long does Soma stay in your system is primarily determined by its half-life. The average half-life of Carisoprodol is 1 to 3 hours; however, this time may differ from one person to another depending on numerous health factors. 

It takes an average of 11 to 12 hours for our body to eliminate Carisoprodol. However, in many people with a lower metabolism, it may procure about 17 to 24 hours for the body to eliminate the Soma pill.  

Elimination of Meprobamate From The Body

Meprobamate is the metabolite of Carisoprodol. How long Soma stays in your system may differ from the time taken by the body to eliminate Meprobamate. The potency of Carisoprodol and Meprobamate is different, and so is their excretion time. 

The half-life of Meprobamate in one dose of Soma 350mg is 10 hours [3]. Thus, the elimination time of Carisoprodol is different than Meprobamate, which may take about 2 to 3 days to leave the system.



Half-Life of Soma

The Soma half-life determines the time taken for half of the dose to eliminate from the system. In general, for a medication to be completely excreted from the body requires numerous half-lives. 

The Soma half-life is 1 to 3 hours for most people, whereas the half-life of Meprobamate is about 10 to 12 hours. 

Based on the half-life, we can conclude that the elimination of Carisoprodol from the body takes about 11 hours and that of Meprobamate is around four days. 


How Long Does Soma Stay in Your Urine, Blood, Saliva And Hair ?

Soma drug testing is not very prevalent and often done in specialized cases. It is, however, detected in different parts of the body apart from urine, which is the primary mode of excretion.

The presence of Carisoprodol and its metabolite, Meprobamate, can be tested in the urine, blood, saliva, and hair follicle. 

Soma drug test detection time



Soma drug tests can detect the presence of Carisoprodol and Meprobamate in the urine for 2 to 3 days from the last dosage. It may last in the blood for about 24 hours, 3 to 4 hours in the saliva, and about 30 days in your hair follicle.


Factors That Affect How Long Soma Stays In Your System

Even though we have an average estimate of how long does Soma stay in your system, there is no specific answer to the question. Several factors determine how long Carisoprodol stays in the system, such as- 




Age of the person- The metabolic activity of an individual governs the lasting of a particular drug in the body. With age, the metabolism of the person declines. Thus age is a significant factor in determining the duration of Soma in the body. Older people may show lower efficacy or take longer to eliminate Soma from the body. It can increase the chance of occurrence of side effects in the user. Older adults over 65 should not take Soma muscle relaxers without consulting a doctor.  


Food intake- How long does Soma stay in your system largely depends on the food taken with the analgesic. Carisoprodol is a sparingly soluble analgesic; thus, it increases bioavailability when taken with a high-fat meal. Based on a study report by Richard H. Roberts [5], the administration of the Soma pill with food decreases the Cmax (maximum serum concentration) of Carisoprodol. Thus, the intake of a heavy meal with the Soma pill can lead to altering the working mechanism of the drug. Users can, however, have a light meal before taking the Soma pill to avoid nausea. 


Fat percentage with body mass- The Soma muscle relaxer is a lipophilic drug that retains Carisoprodol for a more extended period. The fat percentage in the body can affect how long Soma stays in your system and its elimination process. People with a lower body fat percentage will eliminate Soma quicker than users with more fat content. 


Genetics of the user- In a study by Jorgen G Bramness et al. [6], the Carisoprodol in the human body gets metabolized in the liver with the assistance of the enzyme CYP2C19. The CYP2C19 gene excretes this enzyme. So, the number of CYP2C19 alleles in the body determines the metabolism of Carisoprodol in the body. If the medicine takes longer for metabolism, the CYP2C19 gene secretes this enzyme for a longer duration. Thus, the genetic expression of the gene plays a crucial role in determining how long Soma stays in the system.


Hepatic and renal functioning- The elimination of Soma from the system involves the hepatic and renal functioning of the body. Therefore, a person's liver and kidney disorders can affect how long Soma lasts. It can further slow down the removal process of Carisoprodol from the body.


Gender of the user- The data published on Carisoprodol by FDA states that exposure to musculoskeletal pain medication is higher in females when compared to males. At the same time, the exposure to Meprobamate is almost similar in both genders. Therefore, gender is also essential in determining how long Carisoprodol stays in your system.


Carisoprodol dosage- The dosage determines the time needed to excrete Carisoprodol. People taking higher or frequent Soma pills have traces of the medicine for a more extended period. 


Strength of analgesic- The Soma muscle relaxer is available in two main dosages Soma 350mg and Soma 500mg. The strength of the muscle relaxer also plays a primary role in determining how long Carisoprodol stays in your system, thus concluding that Soma 500mg remains longer in the system than Soma 350mg.


Soma Drug Tests- Who May Be Tested For Carisoprodol?

Soma drug testing is rare in a standardized panel and is also not a part of the SAMHSA-5 screening. But in certain conditions, an individual may be tested for it. 


In Drug Rehabilitation-

Rehab patients or people suspected of overdosing or abuse are often tested for Soma pills. It is also detected in people who buy Soma 500mg online and avoid the use of lower doses of the muscle relaxer. Overdosing on Carisoprodol can cause severe health risks in individuals. 


In the Military-

Military officials often are on combat missions or may have to operate heavy machinery requiring optimal alertness, cognition, and vigilance. Soma abuse can cause dizziness and impact their thinking ability. Thus, they often have to go through a Soma drug test during their service. 


Corporate Employees-

Soma drug testing in employees is not frequent and is rarely done. Your employers may test for the Soma pill if-

  • They have a no-drug policy at their organization.

  • If the side effects from the administration of the Soma pill are affecting your productivity.  



The effect of the Soma pill is similar to benzodiazepines (slow reflex, lethargy, blurry vision), which might help criminals for illicit means. Therefore, a suspected convict may be subjected to a Soma drug test. 


Soma Drug Testing- False Positive 

Meprobamate, which is classified as a Schedule IV controlled substance, is the primary metabolite of Carisoprodol and may lead to False-Positive test results. 

The effect of Meprobamate on the brain and body is similar to barbiturates. It has a sedative effect that is essential for Carisoprodol’s efficacy as an analgesic and also has a therapeutic benefit in treating anxiety. 


Tips To Accelerate Soma Pill Excretion


tips-to -accelerate-soma-pill-excretion


Several activities can speed up the process of Soma excretion from the human body. However, these activities must be performed after consulting a doctor. 


Daily exercise- The possibility of Meprobamate accumulating in the adipose tissue lowers by exercising. Therefore daily exercise can alter how long Soma stays in your system. Any form of physical activity will help burn body fat and facilitate the faster elimination of Carisoprodol and Meprobamate from the body. Going for a run or jogging can help if you wish not to indulge in an intense workout routine.


Using supplements- Health supplements such as Calcium-D-Glucarate help clear up the renal detoxification pathways. Detoxification is also significant in determining how long Soma stays in the system. Thus this process helps accelerate the removal of Soma from the body.


Activated Charcoal- A study report by E Hassan [8] indicates that using Charcoal can increase the clearance of Carisoprodol from the circulating system of the body. It works by binding to the remnants of the muscle relaxers present in the person's gastrointestinal tract. The use of activated Charcoal must be done only under the guidance of a physician. 


Level of hydration- Increased water intake can also help improve the process of removing Carisoprodol from the body by speeding up the renal system. 


Soma Drug Testing


By now, you must be aware of the different parts of the body where the presence of Carisoprodol and its metabolite can be detected. Let us now better understand the techniques involved in Soma drug testing. 


Carisoprodol Blood test - 

The detection of Soma in the blood is done to determine the serum concentration of Meprobamate or Carisoprodol. Blood tests are not commonly preferred because it is invasive, have a shorter time frame for detection, and are time-consuming. 

The advantage of detecting Soma through a blood test is its accuracy. If the sample is collected within 4 hours of drug administration, the test can determine the amount of Carisoprodol ingested. 

Gas chromatography/mass spectrometry (GC-MS) techniques determine the level of Carisoprodol and Meprobamate in the blood sample. 


Urine test for Soma-

A fresh sample is collected and analyzed with liquid-chromatography/mass spectrometry (LC-MS) to detect Soma in the urine. 

In some users, the presence of Carisoprodol may be higher, whereas, in others, Meprobamate may be detected in more significant amounts. This variation in their concentration is due to CYP2C19 metabolism. People with rapid CYP2C19 metabolizers have an increased concentration of Carisoprodol, whereas others show higher levels of Meprobamate. 


Hair drug Test-

The consumption of the Soma pill through hair follicles is analyzed by solid-phase extraction (SPE) and gas chromatography/mass spectrometry ( GC/MS). The benefit of Soma drug testing through hair follicles are-

  •  It allows a longer detection time compared to the other methods. 

  • The quantity of Carisoprodol or Meprobamate that appears in the hair follicle is close to the amount of Soma ingested. 

The only drawback of this method is that the time taken for Carisoprodol and Meprobamate to reach the hair follicles is longer. So it is a better option for conditions where the individual is tested 3 to 4 days after the administration. 


Saliva Test-

The use of saliva samples for the Soma drug test is occasional and is possible for a short duration after administration. The collected sample is tested through liquid chromatography/mass spectrometry (LC-MS) that reports the precise Meprobamate concentration in the Saliva. 


How long does Soma stay in your system after stopping?

Most people eliminate Carisoprol within 24 hours and Meprobamate 4 days after the last Soma dosage. 

People with Soma addiction or dependency may take a higher dosage of the muscle relaxer and, therefore, may take around a week to eliminate it completely. 


How long does carisoprodol stay in your system- Our Verdict 

To answer the question, let us run down all the information we have glimpsed on how long Carisoprodol stays in your system. 

The key points-

  • The Soma pill stays in the system for 11 to 24 hours.

  • Meprobamate takes longer to get excreted from the body.

  • Soma drug test is not common and is not detected in the standard 12-panel drug tests. 

  • The detection of Soma in the system is possible for a more extended period in chronic users. 

  • Soma drug testing can be performed in blood, hair, saliva, and urine samples. 

  • One can pass a Soma drug test by discontinuing the administration of the muscle relaxer 7 to 10 days before the examination. 


The hair follicle helps in detecting the presence of Carisoprodol. It takes longer for Carisoprodol to reach the hair follicle, and therefore it also takes longer to get excreted. One can determine the presence of Soma in the hair for up to 30 days

Soma is detected in the Saliva for 3 to 4 hours from the intake of the Soma dosage.

The traces of the Soma pill can be present in the urine much later after its elimination from the blood. It can be present in the urine for 2 to 5 days after the last Soma dosage. This duration of how long Soma stays in the system increases mainly in people with Soma abuse and addiction.

The Soma pain medication can remain in the blood for about 24 hours. This elimination time of Carisoprodol from the blood may depend on the person's metabolism and renal functioning.

Carisoprodol (2410 V round white pill) is a category C [1] medication; therefore, pregnant and lactating women can take the dose only after a physician's consultation. According to a report published by the Queensland Government [2], the medication taken by a nursing mother can pass into their milk. However, mothers should avoid breastfeeding for 1 to 2 hours after taking the drug.


  1. “Carisoprodol”, Wikipedia
  2. "Breastfeeding and Drugs”,

  3. “Soma Compound”,
  4. “Pharmacokinetic modeling of Carisoprodol and meprobamate disposition in adults”, T. Lewandowski, semanticscholar.
  5. “Carisoprodol articles and methods”, patents. google
  6. “Association between blood Carisoprodol: meprobamate concentration ratios and CYP2C19 genotype”, Jorgen G Bramness et. al, Pubmed
  7. "Soma abuse”, Drugabuse

  8. “Treatment of meprobamate overdose with repeated oral doses of activated charcoal”, E Hassan, Pubmed