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How long does Soma stay in the system?

How long does Soma stay in the system?

Soma pill is a prescription medication for treating short-term acute pain in users. The analgesic is very effective and can treat severe lower back pain in addition to other causes of acute pain. Carisoprodol targets the body's central nervous system and prevents pain stimulation from reaching the brain receptors. This blog will help determine how long Soma stays in the system. 


How long does the body take to eliminate Soma?




Soma half-life determines the duration of time required by the body to eliminate it. The average half-life of Carisoprodol is 3 hours. However, this time may differ from one person to another depending on numerous health factors. It takes an average of 11 to 12 hours for our body to eliminate Carisoprodol. However, in many people with a lower metabolism, it may procure about 17 to 24 hours for the body to eliminate the Soma pill.  

Elimination of Meprobamate from the body

Meprobamate is the metabolite of Carisoprodol. How long Soma stays in the system may differ from the time taken by the body to eliminate Meprobamate. The potency of Carisoprodol and Meprobamate is different, and their time of excretion. The half-life of Meprobamate in one dose of Soma 350mg is 10 hours [3]. Thus, Soma's length differs from Meprobamate. It may take about 2 to 3 days to leave the system.


Factors that affect the elimination of Carisoprodol

The process of elimination and how long does soma stay in your system depends on numerous factors. The factors that contribute to how long does Soma lasts are-




Age of the person- The metabolic activity of an individual governs the lasting of a particular drug in the body. With age, the metabolism of the person declines. Thus age is a significant factor in determining the duration of Soma in the body. Older people may show lower efficacy or take longer to eliminate the Soma from the body. It can increase the chance of occurrence of side effects in the user. Older adults over 65 should not take Soma muscle relaxers without consulting a doctor.  

Food intake- How long does soma stay in your system largely depends on the food taken with the analgesic. Carisoprodol is a sparingly soluble analgesic. It increases bioavailability when taken with a high-fat meal. Based on a study report by Richard H. Roberts [5], the administration of the Soma pill with food decreases the Cmax of Carisoprodol. Thus, the intake of a heavy meal with the Soma pill can lead to altering the working mechanism of the drug. Users can, however, have a light meal before taking the Soma pill to avoid nausea. 

Fat percentage with body mass- The Soma muscle relaxer is a lipophilic drug that retains Carisoprodol for a more extended period. It can affect how long Soma stays in the system and its elimination process. People with a lower body fat percentage will eliminate Soma quicker than users with more fat content. 

Genetics of the user- In a study by Jorgen G Bramness et al. [6], the Carisoprodol in the human body gets metabolized in the liver with the assistance of the enzyme CYP2C19. The CYP2C19 gene excretes this enzyme. So, the number of CYP2C19 alleles in the body determines the metabolism of Carisoprodol in the body. If the medicine takes longer for metabolism, the CYP2C19 gene secretes this enzyme for a longer duration. Thus, the genetic expression of the gene plays a crucial role in determining how long Soma stays in the system.

Hepatic and renal functioning- The elimination of Soma from the system involves the hepatic and renal functioning of the body. Therefore, a person's liver and kidney disorder can affect how long Soma lasts. It can further slow down the removal process of Carisoprodol from the body.

Gender of the user- The data published on Carisoprodol by FDA states that the exposure to musculoskeletal pain medication is higher in females when compared to males. At the same time, the exposure to Meprobamate is almost similar in both genders. Therefore, gender is also essential in determining how long Carisoprodol stays in your system.

Carisoprodol dosage- The dosage determines the time needed to excrete Carisoprodol. People taking higher or frequent Soma pills have traces of the medicine for a more extended period. 

Strength of analgesic- The Soma muscle relaxer is available in two main dosages Soma 350mg and Soma 500mg. The strength of the muscle relaxer also plays a primary role. Therefore, Soma 500mg stays longer in the system than Soma 350mg.

Tips to accelerate Soma pill excretion

Several activities can speed up the process of Soma pill excretion from the human body. Such as-

Daily exercise- The possibility of Meprobamate accumulating in the adipose tissue lowers by exercising. Therefore daily exercise can alter how long does Soma stay in your system. Any form of physical activity will help burn body fat and facilitate the faster elimination of Carisoprodol and Meprobamate from the body. Going for a run or jogging can help if you wish not to indulge in an intense workout routine.

Using supplements- The use of the health supplements such as Calcium-D-Glucarate helps clear up the renal detoxification pathways. Detoxification is also significant in determining how long Soma stays in the system. Thus this process helps accelerate the removal of the Soma pill from the body.

Activated Charcoal- A study report by E Hassan [8] indicates that using Charcoal can increase the clearance of Carisoprodol from the circulating system of the body. It works by binding to the remnants of the muscle relaxers present in the person's gastrointestinal tract. The use of activated Charcoal must be done only under the guidance of a physician. 

Level of hydration- Increased water intake can also help improve the process of removing Carisoprodol from the body by speeding up the renal system. However, it is essential to note that one must present in the person's gastrointestinal tract any of these steps into your life; it is best to consult a physician to avoid side effects.

Detection of Soma in a drug test




Several Soma muscle relaxers users want to know how long Soma stays in the system as they worry about being tested for Carisoprodol or its metabolite. However, the Soma pill test is not a part of the standard drug detection test. People such as workers (operating a heavy machine), criminals, military officials, or drug rehabilitation patients are common for testing. 

Requisite of a drug test for Soma pill

A drug test for Carisoprodol or Meprobamate is standard in long-term users. It is because Carisoprodol can be habit-forming if not administered correctly. It increases the chances of Carisoprodol drug abuse in non-prescription users. The risk associated with Soma abuse is high and can lead to causing severe side effects in the patient. Not everyone needs a drug test to know how long does Soma stay in your system to detect the drug impact. If you observe the sign of dependency or addiction in the user, getting the test done is beneficial.

Soma dependency sign

One can identify Carisoprodol abuse in a user by observing the following sign and symptoms [7]-

  • Depression

  • Unable to think clearly

  • Withdrawn from their family and friends

  • Such people purchase Soma pill without a valid medical prescription

  • Feeling uneasy after discontinuing the muscle relaxer.

  • Sleep issues

  • Agitation


The hair follicle helps in detecting the presence of Carisoprodol. It takes longer for Carisoprodol to reach the hair follicle, and therefore it also takes longer to get excreted. One can determine the presence of Soma in the hair for up to 30 days

Soma is detected in the Saliva for 3 to 4 hours from the intake of the Soma dosage.

The traces of the Soma pill can be present in the urine much later after its elimination from the blood. It can be present in the urine for 2 to 5 days after the last Soma dosage. This duration of how long Soma stays in the system increases mainly in people with Soma abuse and addiction.

The Soma pain medication can remain in the blood for about 24 hours. This elimination time of Carisoprodol from the blood may depend on the person's metabolism and renal functioning.

Carisoprodol (2410 V round white pill) is a category C [1] medication; therefore, pregnant and lactating women can take the dose only after a physician's consultation. According to a report published by the Queensland Government [2], the medication taken by a nursing mother can pass into their milk. However, mothers should avoid breastfeeding for 1 to 2 hours after taking the drug.


  1. “Carisoprodol”, Wikipedia
  2. "Breastfeeding and Drugs”,

  3. “Soma Compound”,
  4. “Pharmacokinetic modeling of Carisoprodol and meprobamate disposition in adults”, T. Lewandowski, semanticscholar.
  5. “Carisoprodol articles and methods”, patents. google
  6. “Association between blood Carisoprodol: meprobamate concentration ratios and CYP2C19 genotype”, Jorgen G Bramness et. al, Pubmed
  7. "Soma abuse”, Drugabuse

  8. “Treatment of meprobamate overdose with repeated oral doses of activated charcoal”, E Hassan, Pubmed