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Tapentadol: uses, interactions, brands, side effects, review

Tapentadol: uses, interactions, brands, side effects, review

If you have ever experienced back pain or injured from accidents, you know life with body pain can be difficult. It can affect your daily activity, making it crucial for you to take medical help. Long-term severe pain can be one of the most challenging medical conditions that do not show effective results from generic pain medication. Tapentadol is a proven way to help manage chronic pain in people. It is a centrally-acting opioid medication that works with a dual mode of action, making Tapentadol a better choice of analgesic over other prescription opioids available on the market. The FDA approves this opioid medication to manage users' moderate to severe pain [1]. Let us find in this blog about Tapentadol interactions, brand name, reviews, uses, and Tapentadol side effects.

 

Tapentadol brand names

This opioid pain medication is marketed under several trade names; two common brand names are Nucynta and Aspadol. Both these medications follow a similar mode of action. 

  Dosage forms for Aspadol-

After consulting a physician, users can buy Aspadol online in 100mg and 200mg dosages.

  Dosage forms for Nucynta-  

Generic Nucynta is available in 50mg, 75mg, and 100mg. One can also order Nucynta ER (Extended Release) for 100mg, 150mg and 250mg. 

Prescription uses of Tapentadol

The development of Nucynta is to decrease the intolerability issue associated with opioid medications. The extended formula of the medication shows the effect for 12 hours in the user. It is an effective solution for pain associated with lower back pain, osteoarthritis, and pain associated with diabetic peripheral neuropathy. Tapentadol can use this pain medication to treat acute and chronic pain in people. Studies indicate that using Nucynta has better analgesic effectiveness and gastrointestinal tolerability than other opioid medications. Users can also buy Aspadol online in 100mg for treating somatic, inflammatory, and neuropathic pain. Being well-tolerated in the body makes it a much safer choice and shows a lower possibility of Tapentadol side effects and interactions with other medications in the user.

Tapentadol ( Aspadol, Nucynta) drug interaction

 

Prescription uses of Tapentadol  The Tapentadol pain medication was developed to decrease the intolerability issue that is associated with opioid medications. The extended-formula of Tapentadol is seen to show effect for 12 hours in the user. It is an effective solution for pain associated with lower back pain, osteoarthritis, and pain associated with diabetic peripheral neuropathy. This pain medication can be taken for treating both acute and chronic pain in people. Studies indicate that the use of Tapentadol has better analgesic effectiveness and gastrointestinal tolerability than other opioid medications. Users can also take Aspadol 100mg for treating somatic, inflammatory, and neuropathic pain. It being well-tolerated in the body makes it a much safer choice and shows a lower possibility of side effects in the user.  Tapentadol ( Aspadol, Nucynta) drug interaction

 

The intake of Aspadol 100mg and Nucynta dosages with other medications can cause drug interaction in users. Such conditions can lower the efficacy of the medicine and increase the chances of side effects in the user. People taking this pain medication must avoid using other prescription and nonprescription drugs without a doctor’s consultation.  

 

Table 1: Possible drug interactions of Tapentadol and its brand versions 

Common Tapentadol interactions 

Severity [2]

Alcohol

Mild

Other Opioids 

Moderate

Duloxetine

severe

Topiramate

Moderate

Topamax

Moderate

Amitriptyline

Severe 

Albutoral

Moderate 

 

There are also several questions on the intake of Tapentadol pain medication with other tablets. These lists do not answer and indicate all the possible drug interactions. It is advised for users to take other treatments with the opioid medication under the supervision of a medical professional to avoid Tapentadol's side effects.

 

  Can I take Nucynta with ibuprofen?

The intake of Ibuprofen with Aspadol is advisable. Since it is a weak pain medication and follows a different mode of action, its interactions with Ibuprofen do not cause severe effects [3].  

  Is the intake of Aspadol advisable with Paracetamol?

The intake of Nucynta with Paracetamol is advisable. The mechanism of action for both of these medications is non-identical, making the drug interaction safe. 

 Should I take Nucynta with Tramadol?

The intake of opioid medicines with Tramadol can result in life-threatening medical conditions. Such people are more prone to suffer from serotonin syndrome.  

  Can I take Aspadol with diazepam?

The intake of Aspadol with Diazepam can result in causing breathing issues, sedation, and other life-threatening effects [4]. 

 Should I take Tapentadol with Aspirin?

Tapentadol interactions with Aspirin can bring a dire impact on the user. The most common result is the advent of respiratory distress. Often the interaction causes Central Nervous System depression. Some other effects include dizziness, drowsiness, difficulty concentrating, and impairment in judgment.  

The long-term impact of Tapentadol 100mg

The prescription usage of the pain medication is advisable for three weeks of continuous use. Long-term medication use can cause severe Tapentadol side effects like life-threatening breathing problems. Beginners are more vulnerable during the first 24 to 72 hours of taking the initial dose. A study by Robert Buynak et al.; shows that the Nucynta ER is a well-tolerated medication with no severe side effects in users in 2 years [5]. However, people shouldn't buy Aspadol online for long-term use without consulting a physician. 

How long does Tapentadol stay in the system?

The average elimination half-life of the pain medication (Aspadol and Nucyta) is about 4 hours. The opioid drug takes about 22 hours to remove from the body [6]. Tapentadol interactions with other medications might tamper with this period. A drug screening test can detect this analgesic; inform the administrator about your prescription medication. Also, learn more about "How long Tapentadol stays in your system."

Aspadol and Nucynta user review 

The Tapentadol review shows a positive response for treating chronic pain with very few cases of Tapentadol side effects. With a high potency and effectiveness, this opioid pain medication is getting popular for cases of severe pain. This user review of Aspadol 100mg from WebMD highlights its efficacy and ease of use in patients. Check out the reviews below before you buy Aspadol online.


User review for Tapentadol oral

Source- “User review for Tapentadol oral”, WebMD

 

Tapentadol side effects

The chances of side effects arising from opioid medication are uncommon. However, it is essential to be able to recognize these symptoms in the case of an emergency. Aspadol and Nucynta are associated with causing moderate side effects in the user. Overdosing, improper administration, and Tapentadol interactions with other medications are common causes of facing side effects. People who take Tapentadol online without a prescription are more susceptible to experiencing these after-effects.

 

Table 2: Adverse effects of Tapentadol 

Tapentadol side effect [7]

Indication

Heartburn

Do not need immediate medical attention

Insomnia 

Do not need immediate medical attention

Excessive tiredness

Do not need immediate medical attention

seizures

Requires immediate medical help

Loss of consciousness

Requires immediate medical help

Constipation

Do not need immediate medical attention

Irritability 

Do not need immediate medical attention

Irregular menstruation

Requires immediate medical help

Anxiety

Do not need immediate medical attention

 

According to the Australian public assessment report for this opioid pain medication [9], the toxicity cases reported in users are related to the concentration of the medication in the blood. Moreover, Tapentadol interactions with other drugs also impact the threshold of effects.


Australian public assessment report for Tapentadol

Source- Australian public assessment report for Tapentadol 

 

The above graph shows that the use of Tapentadol 100mg in users every four hours shows a blood concentration of 145 mg/ml. It is considered safe and shows no adverse Tapentadol side effects on the user. Users who buy the pain medication without a medical prescription are therefore advised not to overdose on the pill. The intake of the opioid drug 3 to 4 times a day in nonprescription users will reduce the chances of experiencing side effects.

Tapentadol withdrawal symptoms

Withdrawal symptoms are common in people who suddenly discontinue the use of the analgesic. Users taking the medication under the supervision of a doctor are advised to consult them before discontinuing. However, people who buy Aspadol online without a prescription can adopt the “tapering off” method. Such people must first gradually lower the dosage before completely stopping their intake. It will allow your body to adjust to the lower dosage of the medication. Prior cases of Tapentadol interactions can amplify withdrawal symptoms. Individuals with withdrawal symptoms may face anxiety, shaking, depression, muscle pain, and nausea [8]. 



References-

  1. Tapentadol extended-release for treatment of chronic pain: a review” Nalini Vadiveu et.al, NCBI, 2011. 

  2. “Tapentadol interactions”, Drugs.com

  3. Tapentadol (Palexia): a strong painkiller for moderate to severe pain”, Netdoctor, 2019. 

  4. “Tapentadol”, Medlineplus

  5. “Long-term Safety and Efficacy of Tapentadol Extended Release”, Robert Buynak et.al, NCBI, 2015. 

  6. “How Long Does Nucynta Stay in Your System, and How Does it Show up on a Drug Screen?”, Drugs.com

  7. “Tapentadol tablet- Uses, side effects and more”, WebMD

  8. Tramadol to Reduce Opioid Withdrawal Symptoms”, clinicaltrails.gov

  9. “Australian public assessment report for Tapentadol”, tga.gov, 2011.