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The Best Modafinil Stack For Energy, Focus, Memory And More- Beginners Guide

The Best Modafinil Stack For Energy, Focus, Memory And More- Beginners Guide


Modafinil stacks are defined as combining two or more Nootropics or compounds to enhance their effectiveness. The idea behind it is to create a positive Modafinil synergy where the combined effect is greater than their individual effects. 

Modafinil stacks perfectly well with L Theanine, Noopept, Coffee, Choline, Nicotine, and Ashwagandha to improve memory, cognition, energy, and productivity. 



Modafinil stacks have become one of the fastest and most preferred performance-enhancing methods of choice in workplaces and universities. So, is building the best Modafinil stack an easy task? Or what are the benefits and health risks associated with using Nootropi stacks? 

This blog meticulously answers all such questions to help you understand what Nootropic stacking is and why or how it should be done. 


Modafinil And Nootropic Stack- Beginner's Guide 

Modafinil is a well-tolerated psychostimulant compound with a low potency for addiction and dependency. It is available under brand names including Modalert and Provigil and is clinically approved by the FDA for treating Excessive Daytime Sleepiness associated with Narcolepsy, Obstructive sleep apnea, and Shift Work sleep disorder. 

Modafinil is a Schedule IV controlled substance that is classified as a eugeroic compound. 

Nootropic stacking is combining two or more cognitive-enhancing compounds at the same time to produce greater efficacy [1]. These are known to multiply, synergize, and complement the singular effects of cognitive enhancers. 


Why Stack Nootropics?

The use of Nootropics or Modafinil on its own has an extremely beneficial effect on cognition and wakefulness. But there are several key reasons why people prefer Modafinil stacks, some of which are listed below. 

  • To complement the benefits of the combined stack.

  • To lower the possibility of experiencing some of the side effects associated with each medicine. 

  • To enhance the potency of each of the Nootropic drugs in the combination. 

  • To take advantage of other health benefits that are provided by the other nootropics. 

  • To create a greater synergy between the combined medications. 

To put it in simpler words, the main purpose of a Modafinil stack is to enhance and utilize all the ingredients of both medications to their full potential. So, whether you are trying to enhance your brain power or increase your attention, there is a Modafinil stack for everyone. All you have to do is find or create the ideal Modafinil Stack that works for you. 



Fun Game To Recognize The Power Of Modafinil Stacks

Initially, our team, too, was not fully convinced about the uses and benefits of stacking Modafinil. Also, its associated health risks made most of them avoid using such Modafinil stacks. So, we tried a fun game to fully understand and evaluate the potency of such stacking.  

Given below are three sets of random numbers between 0 and 99. The aim of the game is to see how many sets you can recall in the correct sequence. 

Set 1- A set of 5 numbers. 

7,6,19,56, 90.

Set 2- A set of 10 numbers. 

80, 18, 57, 58, 25, 9, 64, 30, 96, 90

Set 3- A set of 20 numbers. 

33, 22, 29, 77, 90, 79, 3, 32, 26, 1, 99, 17, 81, 70, 3, 12, 7, 29, 58, 13

Rules of the Game-

  • You have one minute to remember the sequence. 

  • You are not allowed to see the number while recalling. 


So, how did you do? Were you able to recall all three sets of number sequences? 

Most people often only recall the first set. Only a few people can recall the first and the second sets, while the number of people who are able to recall all three sets correctly is very low. 

However, with a Modafinil stack that is designed to enhance cognition and memory, it became much easier to recall all three sets correctly in half the time we would otherwise spend remembering them. It is this potency and effectiveness that make Nootropic stacking so popular. 

So, if you are looking to buy Modafinil for your stack, the best online pharmacy for affordable Modalert is Healthnaturo. With a vision to make healthcare affordable and convenient, we provide genuine, quality medication at great discounts. 


Who Uses Modafinil Stacks?

The use of Modafinil stacks is very popular in the corporate sector due to their high work pressure and high stacks to stay focused and productive all day long. 

Dave Asprey, a renowned entrepreneur, in a recent interview with CNN, said that he starts his day by taking Nootropics stack of up to 15 pills. 


According to the  Harvard Business Review, Carl Cederström suggests that the use of smart drugs or Nootropic will become very common in the workplace in a few years. He further brings into light the second group of people with whom the use of Modafinil stack is very popular- among students. The report by Carl Cederström indicates that Up to 20% of Ivy League college students use Nootropics [3]. 

A 2012 Royal Society report suggests that the use of brain stimulants or cognitive enhancers along with other new-age technology for self-improvement will have far-reaching implications on the business world [3]. In 2008, Modafinil was labeled as the  “entrepreneur’s drug of choice” by TechCrunch.


How To Safely Create The Best Modafinil Stack?

Just stacking Modafinil with other Nootropics or cognitive enhancers doesn't mean that it will be able to produce the desired beneficial effect. A fair amount of experimenting and product knowledge is needed to get the right mix. 

But before we talk about creating the best Modafinil stack, let us first understand the form of interactions between them. 

When Modafinil is taken with other Nootropics, it can result in four possible drug interactions. 

  • Synergy- The effects of two drugs are partially or totally additive. 

  • Potentiation- The effect of one drug is increased by the second drug. 

  • Antagonism- The effect of one drug is decreased by the second compound. 

  • Independent Effect- The effects of both drugs are independent of each other. 

One of the biggest mistakes that most Nootropic stack beginners make is exclusively focusing on drug synergy while avoiding any drug antagonism. So, here are a few essential factors to consider to create a safe and effective Nootropic stack. 

  • Targeting a particular outcome- Some Nootropics help in promoting learning and memory, while others help in enhancing concentration and focus. A few Nootropics also help lower stress and anxiety. Thus, it is important to create a stack depending on your targeted effect. 

  • Creating a synergy- A synergy is the interaction of two or more compounds to produce a combined effect that is greater than the sum of their separate individual effects. For example, if you are taking aniracetam to enhance cognition, stacking it with Choline may help, as it helps increase the cognitive effects of aniracetam.  

  • Avoid negative Interaction- A stack is considered good when it contains ingredients that work together without canceling each other's beneficial effects. For example, L Theanine, when taken with caffeine, can help lower its adverse effects. 

  • Simplicity- Often, it is seen that the best stacks are those that contain 2–5 different Nootropis. So, try to avoid mixing two or more compounds in your stack. 


List Of The Best Modafinil Stack- Supplements To Take With Modafinil

As previously mentioned, one of the best ways to create a Modafinil stack is to stay informed about the products. So in the table below are a few common indications for the most commonly used Nootropics and Cognitive enhancers to help you choose your composition wisely. 




Focus and Vigilance    

Racetams, Modafinil, L-Theanine, Armodafinil, and Caffeine. 


Caffeine, Modafinil, Ginseng, Armodafinil, Ashwagandha, and Phenylpiracetam. 

Thinking and memory

Bacopa Monnieri, Racetams, Huperzine A, Ginkgo Biloba, and Centrophenoxine. 

Anti-stress and anxiety

Quercetin, Panax Ginseng, Coenzyme Q10, Ashwagandha, R. Rosea, Holy Basil, and Cordyceps mushrooms 

Better mood    

Ashwagandha, Rhodiola Rosea, St. John’s Wort, and Tianeptine. 


Now that we have a basic idea of the compounds and their key beneficial properties, here is a list of a few common yet effective Modafinil stacks. Based on your needs, you can either give these well-researched and established Modafinil stacks a try or create a new one from the list mentioned above. 


L Theanine And Modafinil

L Theanine is a popular natural Nootropic and has been recognized by the FDA for its medical benefits. 

The use of Modafinil and L Theanine is safe, with no reported drug interactions or severe side effects. Combining Modafinil and L Theanine helps boost the effect of Modafinil and will offer the following benefits-

  • Improving Focus. 

  • Heightened alertness.

  • Promotes a feeling of well-being by regulating the level of neurotransmitters in the brain.

  • Elevates Mood. 

This combination further lowers the risks of side effects caused by Modafinil. This Nootropic stack can effectively lessen anxiety and stress while promoting relaxation without causing sedation [4]. 

Administration Of L Theanine And Modafinil

Take L Theanine an hour or two before bed and several hours after taking Modafinil to combat the wakefulness property of the Nootropic. 

During the day, mixing them together will help you notice less brain fog, decrease the urge to procrastinate, and boost productivity. 

Possible Health Risks Of Taking Modafinil With L Theanine

There are no reported side effects from combining Modafinil with L Theanine. In fact, L Theanine is known to reduce the signs of nausea, irritability, and stomach upset. The use of the amino acid can produce mild side effects such as sleepiness and headaches. However, the effects of long-term use of L-Theanine are yet to be established. 


Noopept And Modafinil

Noopept is a cholinergic Nootropic that produces its beneficial effect by enhancing the activation of acetylcholine receptors. 

Stacking Modafinil with Noopept helps achieve the following benefits. 

  • In improving creativity, memory, and concentration.

  • Enhancing productivity. 

  • Heightened wakefulness. 

  • Indicates a state of mental clarity and quickness. 

  • Enhances the user's motivation to start and complete projects [5]. 

Administration Or Stacking Modafinil And Noopept

  • You can begin by taking the standard Modafinil dose, which is 200 mg. Then start by taking 10 mg of Noopept.

  • When stacking Modafinil, it is best to start it in the morning. However, the second or third dose of Noopept can be taken later in the day, depending on the work schedule. 


Modafinil And Coffee- How Do Caffeine And Modafinil Interact?

Taking Modafinil with Coffee is by far the most popular Modafinil stack that people use and prefer. It is a great combination to achieve mental focus for over 12 hours. 

The benefits of stacking Modafinil with Coffee include- 

  • Increase in productivity by 50 to 60%. 

  • Increases wakefulness by following different mechanisms of action. 

  • They are both responsible for increasing the production of norepinephrine, which is associated with wakefulness and arousal. 

  • It leads to different durations of cognitive enhancement. 

Dosage And Administration Of Modafinil With Coffee

  • Begin by taking 200 mg of Modafinil by 10 a.m. Ensure that you have your first meal around the same time. The appetite-suppressing effects of Modafinil may affect your food intake later in the day. 

  • Followed by drinking your first cup of coffee after 1 to 2 hours of administering Modafinil 200 mg. 

  • One can drink up to 2 cups of coffee over the course of the next 3 to 4 hours. 

  • It is important to avoid drinking Coffee after 2 p.m. to avoid insomnia or any disturbance in the natural sleep cycle. 

Beginners who have not taken Modafinil before are recommended to start with a lower dose and gradually increase their strength. 

  • One cup of coffee with 50 mg of Modafinil.

  • One cup of coffee with 100 mg of Modafinil.

  • One cup of coffee with 200 mg of Modafinil.

  • Two cups of coffee with 200 mg of Modafinil [6]. 


Choline And Modafinil

Mixing modafinil and choline helps in achieving the following benefits. 

  • It helps in reducing Modafinil headaches.

  • It maximizes the positive effects of Modafinil.  

  • Improves long-term and short-term verbal memory. 

  • Lower anxiety symptoms.

Administration Of Choline And Modafinil 

  • Take about 425 to 55 mg of Choline daily. One should not take over 3,500 mg in a day. 

  • Start by taking Modafinil dosage and give it some time to start showing effects. 

  • Then, take 425 mg of Choline. 

Adverse Effects Of Taking Modafinil And Choline

The modafinil-choline mix has no reports of toxicity and no known interaction between the two. However, this does not rule out the possibility of experiencing any health issues from this combination. Some of the reported adverse effects of mixing Choline and Modafinil are listed below. 

  • Nausea

  • Flushing

  • Diarrhea

  • Decrease in appetite

  • Vomiting


Modafinil And Modafinil 

Most people start with a single dose of Modafinil (200 mg). However, there are studies that suggest that splitting this dose into two 100 mg doses of Modafinil can provide better results. 

In such cases, it is recommended to take the first Modafinil dosage in the morning and the second in the afternoon following your lunch. This helps the effects of the Nootropic to remain strong throughout the day. 

Modafinil is commercially available under various brand names, such as Modalert, Provigil, and Modvigil. These brands contain identical active compounds, resulting in comparable effects and potency. Consequently, it is important to acknowledge that any compounds or supplements that can be effectively combined with Modafinil can also be used in conjunction with its respective brand medication.

Stacking Modafinil brand medication with other compounds and supplements will produce the same beneficial effect as Modafinil. 


Modafinil And Nicotine

The use of Nicotine has always been a topic of debate in the healthcare industry. Currently, researchers have isolated the nicotine molecule from tobacco to examine its molecular properties.  The study shows several beneficial cognitive effects on the human brain, including shortened reaction times and athlete performance enhancements. 

A clinical trial by Mehmet Sofuoglu in 2008 suggested that 200 mg of Modafinil with 2 mg of Nicotine lozenges made users feel more energetic and less tired compared to when they took modafinil alone or a placebo. The combination seemed to have a positive effect on their energy levels [7].


The best way to take modafinil with Nicotime is to first take a Nicotine gum to get a rapid dopamine boost, followed by 200 mg of Modafinil for better alertness and energy levels throughout the day. 

The second dosage guide is to take 200mg of Modafinil with 2 mg of Nicotine gum, followed by 200 mg of caffeine in the form of a double espresso. This is, however, not recommended for beginners. It is, however, essential to note that this combination should not be used more than 1 to 2 times a week.  A break of at least 48 to 72 hours should be taken to flush out the medication properly. 


Modafinil And Ashwagandha 

The use of Ashwagandha with Modafinil can help enhance creativity in users. It significantly reduces stress and anxiety in people, which allows for better creative flow. A Randomized Controlled Trial by Kieran Cooley involving 75 healthy adults with moderate to severe anxiety showed 56% improvement with 300 mg of Ashwagandha [8]. 

Anxiety associated with Modafinil may also be a major side effect of the Nootropic. Stacking Ashwagandha with Modafinil can thus help manage such mental health issues in people. 


CBD Oil With Modafinil 

The use of CBD oil with Modafinil is considered safe. However, this combination must be avoided in patients with narcolepsy, as it may make the medication less effective for this condition. 

Stacking CBD oil with Modafinil helps lower insomnia associated with the Nootropic when administered later in the day or in large dosages. 


It is advised to take the Modafinil 200 mg dose in the morning as you usually would. Then, take the CBD oil 1 to 2 hours before bedtime for best results. 

It is advisable not to take this combination on a regular basis. 


The Best Modafinil Stack For Studying




The best Nootropic stacks for students are typically those that boost memory formation. Stacking Modafinil with the following compounds may be beneficial in increasing focus, attention, and motivation in students. 

  • 300 to 600 mg of Choline with Modafinil- Increases memory and focus. 

  • 200 mg of L-Theanine- Lowers stress and improves focus. 

  • 450 to 900 mg of Ashwagandha Powder- This helps in managing stress in students. 

  • 300 to 600 mg of Piracetam- Helps improve memory and retention of information. 

  • 1 to 2 caps of Lion’s Mane- It is an edible mushroom that grows naturally in Europe, North America, and Asia. It helps improve the memory and cognitive functioning of the human brain. User reports also suggest that stacking Modafinil with Lion's Mane can reduce anxiety and increase focus. 

  • 20 to 30 mg of vinpocetine- Helps improve memory. 


Modafinil Stack For Energy, Motivation, Brain Fog, And Focus

A combination of natural supplements, racetam, and choline boosters will help maximize the effects of Modafinil on mental focus and energy. 

  • 500 to 1,000mg Centrophenoxine- It is a source of Choline and works well with Racetam to improve attention span, focus, and cognitive ability. 

  • 250mg to 500mg of L-Tyrosine- It helps boost the level of dopamine in the brain to elevate mood and make you feel energized.

  • 400mg of Sulbutiamine- It helps elevate the mood, alertness, memory, attention, and focus of the user. 


The Sleep Stack 

Most Modafinil users struggle to fall asleep due to its wakefulness-promoting property. So, taking Modafinil with certain compounds can help lower the eugeroic effect of the Nootropic, thus helping induce sleep. 

Following several careful experiments and tests, the following supplements are considered safe and effective in lowering the wake-promoting effect of Modafinil. 

  • 66mg of CBD. 

  • 600 mg of Ashwagandha. 

  • 60 ml of tart cherry juice. 

  • Two cups of camomile tea. 

Chamomile Tea is known to help induce sleep due to its high concentration of apigenin, an anti-oxidant. Studies show that apigenin has an antidepressant, anti-anxiety, and sleep-promoting effect [8]. Whereas Tart cherry juice is rich in melatonin, which helps regulate the normal sleep cycle [9]. 


Modafinil Stacks- Our Final Thoughts 

Modafinil is one of the safest and most effective Nootropics in the pharmaceutical industry today. Though it works great on its own, stacking Modafinil with other compounds can make it more effective. 

There is no such thing as the "Best Modafinil Stack," as it is entirely contextual and may vary from person to person. So, while creating your own Modafinil stack, it is essential to take into consideration your desired health goals and mental performance. 

Modafinil or Modalert stacks incredibly well with L Theanine, Nicotine, Caffeine, Choline, and Noopept.


Pros of Modafinil Stack 

Cons Of Modafinil Stack 

It helps boost cognition beyond the peak of a single Nootropic supplement. This is because each compound follows a separate mechanism of action. Thus, using more than one supplement can help achieve a stronger effect. 

Nootropic stacking can be expensive. 

The side effects of one Nootropic compound can be neutralized or improved by another compound. 

For example, the use of choline can help lower the adverse effects of racetam. 

It is best designed by people who understand the medication well. Thus, experimenting with Nootropics without adequate knowledge may result in overdosing or causing several health risks. 

Nootropic stacking will help you get a broader range of effects. 

Modafinil stacks are much stronger than individual administrations of these Nootropics. Thus, they have a higher risk of causing dependency. 


Modafinil Stack Advice

Stacking should be done correctly to avoid any possible health risks and adverse drug interactions. 

Modafinil is a prescription medication, and hence, we at Healthnaturo do not support or suggest taking or stacking Modafinil or any other cognitive enhancer without consulting a doctor. 


The Modafinil stack recommended for better focus includes L-Thyrosine, Centrophenoxine, and Sulbutiamine.

Stacking Modafinil and Piracetam can result in a synergistic benefit resulting in a wide range of positive effects. This combination can improve your sensory perceptions, memory, and reasoning ability.

Yes, it is usually considered safe to take Modafinil with Piracetam and Choline. The use of Piracetam helps in reducing tunnel vision that one may experience from Modafinil. Begin with taking Modafinil 200 mg dosage and then allow it to start acting, which may take around 30 minutes. Then take 1 gram of Piracetam along with the Choline supplement. Remember, do not overdose on Choline.

Taking methylphenidate with Modafinil may result in a delay in the oral absorption of Modafinil. However, this delay is not clinically relevant. It is, however, best to consult a doctor before taking them together.

Raking  Strattera and Modafinil together is considered a powerful stack. The benefits of this Modafinil stack include- 

  • Improving attention span and focus. 

  • Helping with executive function skills such as organizing and planning. 

  • Enhancing memory formation and recall. 

Adrafinil and Modafinil have similar potency and clinical benefits; thus, administering them together might increase their potency along with their side effects. Thus, before stacking Adrafinil with Modafinil, it is best to consult a doctor.

Taking two Modafinil 200 mg pills may result in overdosing, causing dizziness, headache, agitation, heightened anxiety, dystonia, and tremors. If you wish to take a split dosage of Modafinil, it is best to take 100 mg of Modafinil once in the morning and once in the afternoon after lunch.

Modafinil can be taken with Choline and Piracetam for better focus.

Drinking Coffee with Modafinil can help get enhance cognitive functioning. It is safe to take Modafinil 200 mg with 2 cups of coffee a day.


  1. The Best Nootropic Stacking Strategies for Ultimate Brainpower, Mindlabpro. 

  2. Are smart drugs driving Silicon Valley, CNN. 

  3. Like It or Not, “Smart Drugs” Are Coming to the Office, Harvard Business Review. 

  4. L-Theanine and Modafinil Mix: Effects & Benefits [2023], Modafinil. 

  5. Noopept Modafinil Stack Benefits, Dosages & Safety, nootriment. 

  6. Modafinil and Coffee | What You MUST Know, 

  7. Modafinil and nicotine interactions in abstinent smokers, PubMed. 

  8. Apigenin: Top 8 Benefits Reviewed - HealthNews.

  9. Does Tart Cherry Juice Promote Better Sleep,