How long does Tapentadol stay in your system?

 

Wondering how long does Tapentadol stay in your system? We have answers for you.

Tapentadol is a prescribed pain medication that helps to ease moderate to severe body pain. With a dual mechanism of action, it is considered one of the most effective and safest analgesics on the market.  

Tapentadol is marked under the brand name Nucynta and Aspadol. It is an opioid analgesic, thus raising lingering questions on the use and action of the analgesic. One question that arises in the mind of Aspadol users is, “How long does Tapentadol stay in the system?" 

This blog answers some of the most commonly asked questions to help you better understand the use and mechanism of Tapentadol.

 

How Long Does Tapentadol Stay In Your System | An Overview

 

 

The duration of time Tapentadol stays in the system may vary in people. The primary factor that contributes to the time needed by the body to eliminate the Tapentadol compound is its half-life. 

Half-life of Tapentadol 

The half-life of Tapentadol is approximately 3.93 hours [1]. A medication's half-life is the time it takes for its effectiveness to be cut in half after a person stops taking his last dose. This time is vital in determining how long Tapentadol stays in your system.

Theoretical Evaluation Of How Long Does Tapentadol (Nucynta) Stay In Your System?

The standard dose of Aspadol or Nucynta is 100 mg. So, let us consider the time the dosage was initially taken as "zero" hour. 

 

 

Based on the medication's half-life, Tapentadol stays in your system for about 20 to 22 hours, which may differ based on numerous health factors. 

One can get Aspadol with safe payment options and a hassle-free refund policy from Healthnaturo, which aims to make healthcare services affordable and convenient. 

 

How Long Does Nucynta Stay In Your Urine?

Aspadol or Nucynta dosage can be detected in the urine for 3 to 4 days from the last dose administered [2]. It may, however, last for a longer period in people with renal (kidney) disorders. 

 

How Long Does Tapentadol Stay In The Hair?

The hair retains Tapentadol for the most prolonged period. The presence of Nucynta in the hair can last up to 90 days from the last intake of the dosage [3].

 

Factors That Influence How Long Tapentadol Stays In Your System

People with higher body mass store the drug in the fat molecule. 

Metabolic rate -

Like most medications, Tapentadol is metabolized in the liver. People with a liver disorder or slower metabolism take longer to break down the drug, thus slowing down the potency of the analgesic. 

Age-

Clinical studies show that there can be about a 30% reduction of liver activity in elderly people, thus slowing down their metabolic activity.  

Tolerance-

Long-term use of medication can build tolerance, meaning that the body gets used to the medication and thus does not show an effective result from its use. Such people often are recommended a higher dose of Tapentadol, thus taking longer for the body to eliminate the compound. The factors that affect how long Tapentadol stays in your system include-

Body Mass-

People with higher body mass store the drug in the fat molecules. This tissue acts as a reservoir of extra drug that releases it into the bloodstream, thus prolonging the effect of the medication. 

The image below represents how body weight or obesity affects the pharmacokinetic and functioning of the medication in the body, as described in a 2023 study by Julien Gouju and Samuel Legeay. 

 

 

Metabolic rate -

Like most medications, Tapentadol is metabolized in the liver. Thus, people with a liver disorder or slower metabolism take longer to break down the drug, making Tapentadol stay longer in the system. 

Liver dysfunction can reduce plasma clearance of the medication while lowering its elimination rate, suggests a 1998 study by R K Verbeeck and Y Horsmans. 

Age-

Clinical studies show that there can be about a 30% reduction of liver activity in elderly people, thus slowing down the metabolic activity of the person. 

Tolerance-

Long-term use of medication can build tolerance, meaning that the body gets used to the medication and thus does not show an effective result from its use. Such people often are recommended a higher dose of Tapentadol, thus taking longer for the body to eliminate the compound. 

 

Tapentadol Prescription Usage

Tapentadol 100mg is a prescription medication approved by the FDA for treating acute and chronic pain. This pain medication helps to treat moderate to severe body pain. The correct analgesic use is also very effective in helping prevent the long-term side effects of Tapentadol. Thus, people taking Nucynta opioid medication can follow these tips for a better result-

• The use of the analgesic is not for pregnant and lactating women.

• The Tapentadol pain medication is an oral pill, so take it by mouth.

• People over 65 years and below 17 years old should avoid taking this opioid medication without consulting a doctor.

• People with kidney, liver, and heart disorders should refrain from using analgesics without consulting a doctor.

• Food intake before taking the dose affects how many hours Tapentadol lasts in the body. Thus, one should avoid heavy meals before taking the Tapentadol dosage.​

 

Can Aspadol Dosage Determine How Long It Stays In Your System?  

The dosage of Aspadol is very effective in deciding how long it stays in your system. A high dose of Aspadol will take longer to get eliminated from the body. Thus, the strength and the number of pills taken play a crucial role in determining how many hours Tapentadol lasts. 

The initial dose of the analgesic for beginners is 50mg; however, the standard dose of Aspadol is 100mg. 

Clinical studies show it has a high tolerance; thus, the long-term use of Tapentadol is considered safe. The key factors to consider while taking Tapentadol dosage are-

• Do not take Tapentadol ER more than twice a day.

• One can take Tapentadol IR three to four times a day.

• The administration of Tapentadol with alcohol is not advisable.

• Taking other medication with Tapentadol is not advisable as it can lower its potency by causing drug interactions.

• Doctors do not recommend the long-term use of Tapentadol. One can take this pain medication for three weeks continuously.

 

Physician's Views On How Long Does Aspadol (Tapentadol) Last? 

The time taken by the body to eliminate Tapentadol and its metabolite from the system is 8 to 10 hours for patients with no kidney or renal impairment, according to Dr. K.S. Dastoor.

"The metabolites of Tapentadol can, however, be identified in the body for at least 3 to 5 days. It is, however, generally not included in most drug tests." says a doctor on the website JustAnswer [4]. 

 

How Long Does Nucynta ER Stay In Your System?

The Nucynta ER is the extended-release formulation of Tapentadol that has a longer half-life and helps in treating chronic body pain. The mean terminal half-life of Nucynta ER is 4.4 to 5.9. On average, after an oral administration, the half-life of Nucynta ER is 5 hours. 

About 97% of the compound is metabolized, of which 70% is excreted as urine. The total rate of Nucynta ER clearance is 1603 +/-227 mL/min [5]. Thus, it takes 24 to 48 hours for Nucynta ER to leave the human body. 

 

Will Nucynta Show Up On A Drug Test?

Several drug tests confirm the presence of Tapentadol in the body. The low Tapentadol price and its low chances of side effects are common reasons people take it without consulting a doctor. 

The accuracy of the test depends on the time gap between your last dose and the test. So, if you are taking the analgesic, it is best to discontinue the analgesic intake a few days before the test to get a negative test report. 

 

Will Aspadol Show On A Urine Test?

Tapentadol will show up in urine tests. The drug test administrator should be informed if you are taking and have recently taken the Aspadol dosage under medical supervision. 

Nucynta can be detected in the urine for about 3 days from the last administered dosage. 

Tapentadol And Metabolite Urine Quantitative Test 

Numerous methods often perform the detection of Tapentadol in urine. The urine Quantitative screen test is approved by the Department of Health, New York [6]. It can detect the presence of Tapentadol along with its primary metabolite N-desmethyltapentadol and Tapentadol-O-sulfate. 

- Drug Test: Tapentadol Urine Screen

Methodology: Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Reported: 2 to 6 days

Specimen Required: About 2ml of the urine sample.

The cut-off concentration to be tested positive for Tapentadol is:

 

 

Cut-off concentration refers to the minimum concentration of a drug that should be present to be considered positive [7]. 

 

Does Nucynta Show Up On A 12-Panel Drug Test?

Tapentadol is not tested in the 12-panel drug screen, but it does test the presence of other opioid analgesics in the system, such as Methadone, Opiates, and Oxycodone. It can, however, produce false positives if taken in higher doses. However, a 2012 study by Shirin Tang Et al. indicates that the use of Tapentadol up to 600mg per day does not produce false positives on the drug test [8]. 

 

Tapentadol Warnings

 

 

The use of Tapentadol is safe and is not associated with severe adverse effects. Following dosing guidance and warnings, you can estimate how many hours Nucynta lasts. Tapentadol 100mg warnings showcase that overdosing on this pain medication can lead to long-term side effects. Some of the critical Tapentadol warnings to take into consideration while taking analgesics are-

• Tapentadol 100mg might be habit-forming. 

• Long-term side effects of Tapentadol occur if the analgesic is taken for more than three weeks continuously.

• Sudden discontinuation of Tapentadol can cause withdrawal symptoms in the user.

• Tapentadol abuse can cause severe side effects and dependency in people.