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Ultimate Guide To Know About Aspadol (Tapentadol) Uses

Ultimate Guide To Know About Aspadol (Tapentadol) Uses


Aspadol (Tapentadol) is a pain reliever that treats post-surgery Pain, Neuropathic Pain, Fibromyalgia, and Osteoarthritis. It is also an effective treatment option for managing body pain associated with cancer, headaches, toothaches, and period pain by blocking the chemical messengers that produce the pain sensation in your brain. 



Wondering about the correct uses of Aspadol and its medical benefits? If so, we have you covered. 

Aspadol, the brand drug of Tapentadol, is a centrally acting analgesic drug that is prescribed for treating a wide range of acute and chronic body pain. It is also considered to be the best pain reliever compared to other narcotics for patients with diabetes. 

In this blog, we will discuss all the uses of Aspadol in detail and how it helps manage body pain. 


Aspadol 100mg Tablets: An Overview 

Aspadol, manufactured by Signature Pharmaceuticals Pvt. Ltd., is suggested to be the first agent in a new class of drugs that exhibit a dual mechanism of action. A 2017 study by Ariane Stollenwerk et al. confirms the tolerability profile of Aspadol that emerges through its clinical trials. 

The active compound of Aspasol (Tapentadol)  was developed in the early 2000s by the German pharmaceutical company Grunenthal GmbH and was approved by the FDA in 2008. Aspadol belongs to the Schedule II controlled substance category and is not retailed without a valid medical prescription. 


What Are The Aspadol (Tapentadol) Uses?




Aspadol is approved in the US market for the treatment of moderate to severe acute pain in adults, whereas the extended-release formula (Aspadol ER) is prescribed for managing chronic pain. It is an effective therapeutic option for toothaches, headaches, period pain, pain in joints and muscles, rheumatoid arthritis, and osteoarthritis.  

If you, too, are struggling with body pain, you can buy Aspadol 100 mg at a 20% discount from Healthnaturo. 

Aspadol Tablet Uses In Post-Surgery Pain

The use of Aspadol to reduce acute pain intensity following orthopedic surgery in Korean patients was suggested by Y. K. Lee et al. in a 2014 study. This was further demonstrated in another study by Prasanna Vadhanan et al. that suggests the single use of Tapentadol 100 mg given 30 minutes before surgery reduces postoperative pain intensity and postoperative analgesic requirements compared to placebo, as graphically represented below. 




Tapentadol (Aspadol) was also proven to be a better analgesic than Tramadol for pain relief after cardiac surgery due to its norepinephrine reuptake inhibition properties. 

Along with cardiac surgery, its use is also suggested for the relief of acute pain following orthopedic surgery (Jens-Ulrich Stegmann et al., 2008 study),  postsurgical dental pain (Kleinert et al., 2008 study), after laparoscopic cholecystectomy (Ghanshyam Yadav et al., 2016 study), and total hip arthroplasty (Tiziana D’Amato et al., 2019 study). 

Whereas the prolonged-release formulation, or Tapentadol (Aspadol), ER is effective for patients with severe chronic lower back pain, according to a 2019 study by Thierry C. Bagaphou et al. 

Aspadol For Neuropathic Pain

The use of Aspadol ER in effectively treating neuropathic pain, a pain arising directly from a lesion or disorder affecting the neurons of the somatosensory system, was suggested by Thierry C. Bagaphou et al., as shown in the graph below.   




- Tapentadol In Managing Painful Peripheral Neuropathies

The dual mechanism of action of Tapentadol contributes to its ability to manage painful peripheral neuropathies (PPN). The norepinephrine reuptake inhibition (NRI) action of Tapentadol appears to be dominant over the μ-opioid receptor agonism (MOR) activity, thus helping manage PPN. 

- For Chemotherapy-Induced Neuropathy

Following 3 months of treatment with Tapentadol, the average Douleur Neuropathique 4 (DN4), a screening questionnaire to identify neuropathic pain (NP) in research and clinical practices, declined significantly in patients with chemotherapy-induced peripheral neuropathy, according to a study by Ulderico Freo et al.

Aspadol In Cancer Pain Management

Tapentadol prolonged release or extended-release formula was reported to be well tolerated in all clinical studies with cancer pain patients, according to a 2019 study by Hans G. Kress et al. A Cochrane review published in 2015 suggests that tapenatdol (Aspadol) was as effective as oxycodone or morphine in relieving pain in cancer patients. 

Preliminary evidence also suggests that tapentadol may also be a suitable therapeutic option for managing pain associated with oncological treatments such as chemotherapy. 

Aspadol Uses For Osteoarthritis 

Aspasol, or Tapentadol, offers similar effectiveness in treating severe chronic pain associated with osteoarthritis pain as oxycodone but with a better safety and tolerability profile, according to a study by Joseph V. Pergolizzi Jr. et al. Further, the study indicates that the lower risk of side effects of aspadol makes it a promising treatment option in long-term analgesic therapy. These findings were also similar to another study by James E. Wild et al., that suggested the use of Tapentadol ER offered sustainable relief from severe hip osteoarthritis for up to 1 year with better gastrointestinal tolerability than Oxycodone. 

Managing Pain Associated With Fibromyalgia 

The use of Tapentadol (Aspadol) for treating fibromyalgia, a chronic musculoskeletal pain estimated to affect 2 to 4% of the population, was more effective and potent in patients with a normal corneal nerve fiber state (CNFS), according to a 2019 study by Tine van de Donk et al. It further suggests that people with abnormal CNFS did not respond well to the treatment. 

Does Aspadol (Tapentadol) Make You Lose Weight?

Yes, Aspadol makes you lose weight, as it may result in a loss of appetite in some users. Overdosing on Tapentadol can lead to serious gastrointestinal problems like changes in appetite, vomiting, weight loss, and malnutrition [2]. 

Is Aspadol Good For Sleep?

Aspadol (Tapentadol) helps provide better sleep quality. According to a 2021 study by Renato Vellucci et al., Aspadol, along with pain reduction, fosters better sleep quality and improvement in life [4]. 

The study, along with establishing its significant ability to reduce pain intensity, also reported that the percentage of patients with disturbed sleep lowered with the intake of Tapentadol (Aspadol) administration. The graph below represents the sleep quality of patients receiving Tapentadol ER. 




Benefits Of Aspadol 100 Mg For Pain Management 

Four noteworthy clinical benefits of Aspadol (Tapentadol) 100 mg for effective pain management are listed below. 

Quicker Onset Of Action- 

The action of Aspadol 100 mg tablets starts within 30 minutes after administration. 

Dual Mechanisms Of Action- 

Aspadol is the first analgesic with a dual mechanism of action approved by the FDA that helps contribute to its ability to treat both acute and chronic pain. 


Aspadol is available in two formulations, which include immediate-release tablets (IR) and extended-release tablets (ER).

Better Efficacy And Tolerability-  

Tapentadol or Aspadol is two to three times more potent than other analgesics, such as Tramadol, according to a study by Lucien Roulet and others. Its tolerability was also established by a 2021 study by Renato Vellucci et al., as shown in the graph below. 




Aspadol Dosage For Effective Pain Management 

Aspadol 100 mg is most commonly prescribed for dosage for treating body pain. 

The initial dose of Aspadol 100 mg should be taken every 4 to 6 hours. 

The maximum dose for day 1 is 700mg and 600 mg for the subsequent days. 




1. You should use the lowest effective dosage

2. You should closely monitor the respiratory depression within 24 to 72 hours.

3. You should reserve seats for patients with alternative treatment options. 



How To Use Aspadol

The Aspadol tablets come in oral form and should be swallowed with a glass of water. Furthermore, they must not chewed or crushed. The intake of the Aspadol pills with or without food is advisable. However, do not take them with alcohol or other medication or supplements. 


Precautionary Measures While Using Aspadol

  • Avoid taking this opioid pain medicine if you have severe breathing problems or obstruction in bowel movement. 

  • Always inform your doctor if you are allergic to any of the compounds present in the formulation of the medication. 

  • You should not take the medication if you are pregnant or breastfeeding as it may cross the blood barrier and affect the health and growth of the infant. 

  • It is recommended to avoid activities that require an immediate response, such as driving or the operation of heavy machinery. 


What Are The Possible Side Effects Of Aspadol?

Some of the common side effects of taking Aspadol as a pain medication include coughs, cloudy urine, fever, bladder pain, a sensation of heaviness, trouble swallowing, loss of appetite, and dizziness.

In addition, a few side effects that may require immediate medical attention include itching, rash, seizures, vomiting, irregular menstruation, difficulty breathing or swallowing, excessive sweating, and chest pain. 


Aspadol Uses Conclusion

Aspadol is the brand name for the compound Tapentadol Hydrochloride, used as a pain reliever. Its dual mechanism of action makes it an effective treatment option for managing moderate to severe acute and chronic pain, including toothache, fibromyalgia, period pain, and neuropathic pain, by blocking the chemical messengers that produce the pain sensations in your brain.


Tapentadol can cause a loss of appetite, along with fatigue and drowsiness.

Tapentadol can cause rapid weight loss as it leads to a decrease in appetite.

Chest pain, change in consciousness, difficulty or trouble breathing, increased sweating, and decreased awareness or responsiveness are some of the side effects of taking too much Tapentadol.

The use of Aspadol is not approved by the FDA to treat signs of depression. Moreover, its overuse can lead to sudden mood changes. If you are experiencing symptoms of depression, such as sudden physical and behavioral changes, loss of appetite, low energy level and concentration, suicidal thoughts, changes in daily behavior, and low self-esteem, consult a doctor immediately.

Aspadol 100 mg is effective for treating nerve pain within 30 minutes of intake.

Yes, taking Aspadol dosage is seen to increase the heart rate by 10 beats per minute (bpm), especially for those with a history of hypertension, according to a 2011 study by Robert Lee.


  1. Tapentadol, Medlineplusdrug Information. 

  2. Tapentadol Withdrawal and Detox, therecoveryvillage. 

  3. Tapentadol, Wikipedia.

  4. Pain reduction induced by tapentadol in patients with musculoskeletal chronic pain fosters better sleep quality, NCBI.