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Baclofen vs Soma: Comparison Based on Clinical Studies & Expert Opinions

Baclofen vs Soma: Comparison Based on Clinical Studies & Expert Opinions


Baclofen vs. Soma is a comparative study of the two most popular muscle relaxers for skeletal and neuromuscular pain. 

Approved by the FDA, the Soma pill is a better analgesic choice for people looking for effectiveness on a budget. Both muscle relaxers have similar health risks; thus, Baclofen cannot be an alternative to the Soma pill. Baclofen is recommended to people looking for oral solutions and intrathecal and Transdermal ways to administer the muscle relaxer.



Baclofen vs. Soma is a common muscle relaxer comparison often discussed by patients and healthcare professionals to determine the proper analgesic treatment for body pain. 

Soma pill and Baclofen are muscle relaxers prescribed for skeletal muscle pain. They have a quicker onset of action and begin to work within 30 minutes of intake. Both belonging to the same drug class, both muscle relaxers showcase similarities in their action and user benefits. However, they differ in certain factors that make it essential to be aware of the medications to make an informed decision. 

This Soma vs. Baclofen comparison takes a detailed look into the similarities and differences between the two muscle relaxers to help you choose the right muscle relaxer. 


Soma Vs Baclofen- An Overview

Baclofen and Soma pills are effective analgesics that are often prescribed for short-term acute pain.

Soma pill: Soma pill is a brand drug for Carisoprodol that was approved by the FDA in 2006 [1]. Also called Dan 5513 pills, it is one of the USA's most effective and popular muscle relaxers. According to a survey evaluating the Carisoprodol usage statistics in the USA, about 872,202 prescriptions were written in 2019 [2]. 


Baclofen: Also available under the brand names Lioresal and Gablofen, it is an effective treatment for short-term body pain. Its medical use was approved by the FDA in 1977. In 2020, it was also the 108th most commonly prescribed medication, with over 6 million prescriptions in the USA [3]. 



Soma Pill 


Generic name



Brand name

Soma pill, Pain o Soma, Prosoma, Carisoma. 

US Brand Name:

  • Lyvispah.

  • Fleqsuvy.

  • Ozobax.


Canadian Brand Name:

  • Lioresal.

  • Lioresal Double Strength [4]. 


HAB Pharmaceuticals.

Rosemont Pharmaceuticals.

Legal Status

  • USA- Schedule IV prescription drug. 

  • UK: POM (Prescription only).

  • US: Prescription only.

  • AU: S4 (Prescription only).

Class of drug

Skeletal muscle relaxant.

Skeletal muscle relaxant. 

Structural differences



Soma pill differs from Balcofen in its chemical structure. 

Soma pill contain two phenol and cyclohexane rings and methyl and ethyl groups. 

Baclofen has four carbon chains with carboxylic acid and an amino group at each end. It also has a chlorine atom attached to a benzene ring. 


Active Compound



Inactive Compound-

Povidone, Stearic acid, Starch, hypromellose, Croscarmellose sodium, Magnesium stearate, and Microcrystalline cellulose. 

Active Compound- Baclofen.


Inactive Compounds- Colloidal silicon dioxide, Sodium starch glycolate, Pregelatinized starch, Microcrystalline cellulose, and Magnesium stearate [5]. 


Baclofen Vs Soma- A Comparison Of Their Uses And Benefits

Baclofen was initially used to treat epilepsy in 1960. However, due to a lack of satisfactory reports, it was discontinued. It was then reintroduced in 1971 to treat muscle spasticity [6]. 

FDA-approved indications for Baclofen: 

  • The primary therapeutic use of Baclofen has been for treating spastic movement disorder (a condition resulting in muscle stiffness) from cerebral palsy, spinal cord injury, and multiple sclerosis. It is also an effective treatment for sleep-related painful erections [3]. 

  • Intrathecal Baclofen is used for treating spasticity of cerebral origins, such as severe spasticity of the spinal cord and traumatic brain injury [6]. 

Off-label uses of Baclofen: 

  • Studies show that using Baclofen for Alcohol use disorder (AUD) is effective for moderate to severe symptoms. In European countries and Australia, Baclofen is significant in treating AUD who do not respond to their first-line treatment or have a liver issue [7].

  • For managing signs of hiccups, gastroesophageal reflux disease, and Trigeminal neuralgia [6].


Soma Pill: Soma pill is a prescription drug for treating muscle spasms from sprains and strains. Proper rest and physical therapy are often recommended for a better result. In severe cases, it is prescribed for back pain to help relieve muscle stiffness and help increase movement [8]. 

Off-label uses of Carisoprodol (Soma pill)-

  • The use of the Soma pill for treating period cramps is very effective for treating discomfort associated with primary dysmenorrhea. Since the uterus is a muscular organ, it effectively relieves pain. 

  • The sedative effect of the Soma pill can help with anxiety by calming the brain and the central nervous system. 

  • Muscle relaxers such as the Soma pill can help relieve tension headaches by relaxing the brain's blood vessels, thus managing signs of migraine. 


Baclofen Vs. Soma For Fibromyalgia

Fibromyalgia is a chronic health disorder that causes tenderness and pain throughout the body [9]. So, which among Soma vs. Baclofen is a better treatment option for Fibromyalgia? 

A clinical trial on forty-three of fifty-eight (74.1%) female patients with fibromyalgia suggests that Carisoprodol effectively reduces the pain associated with the condition. It also improves sleep quality and the sense of well-being [10]. 

A survey on the use of Carisoprodol in Fibromyalgia suggests its effectiveness in treating body pain [11].




A research article on the Practical Pain Management website suggests that administering Carisoprodol or Soma pill at 1200mg/day can significantly reduce pain associated with Fibromyalgia [12]. 

Phase IV clinical trials on using Carisoprodol for Fibromyalgia suggest an overall rating of 3.2 and a long-term rating of 3.4 out of 5 [13]. 




On the other hand, studies show no evidence to support using Baclofen or other similar antispasmodics for treating Fibromyalgia [14]. 

A survey report based on 1084 individuals using Baclofen for Fibromyalgia suggests it is not a common therapeutic option [15]. 





A phase IV clinical trial based on 59 users for treating Fibromyalgia with Baclofen showcased an overall rating of 2.8 out of 5 and a long-term rating of 2.9 out of 5 [16]. 




The comparison between the two muscle relaxers indicates that Carisoprodol (Soma pill) is a much more effective treatment option for Fibromyalgia. 


Is Baclofen Like Soma- Evaluation Of Their Similarities 

Both Soma pills and Baclofen have similar properties that make it hard to choose the right muscle relaxer between the two. Some similar factors between Carisoprodol and Baclofen are:

  • Drug Class- Soma and Baclofen are centrally acting muscle relaxers that work on short-term acute pain.


  • The onset of Action- Both medications work within 30 minutes of intake. 


  • Prescription Drugs- Baclofen and Soma pill are prescription drugs and are not available over the counter. 


  • Sedative Potential- Operation of heavy machinery and driving vehicles are not recommended after taking either the Soma pill or Baclofen, as they cause sedation. 


  • Pregnancy Category- Both Baclofen and Soma pill are category C pregnancy drug and is not recommended for pregnant and lactating mothers. 




  • Withdrawal- Abrupt discontinuation of the Soma and Baclofen medication can cause withdrawal signs, and thus the dosage should be gradually lowered before completely stopping it. 


  • Health Condition- People with a history of kidney, liver, and heart disorders are recommended dosage adjustments and often refrain from taking Soma and Baclofen medication. 


Baclofen 20 Mg Vs Soma- Understanding The Differences 

Along with similarities, both Soma and Baclofen have numerous notable differences. Some of them are mentioned below. 

Mechanism Of Action

Mechanism Of Action is the biochemical process that helps a medication produce its beneficial effects [17]. 


The working mechanism of Baclofen -

The mechanism of action of Baclofen is by binding to GABA (gamma-aminobutyric acid) receptors in the central nervous system. When the GABA receptor is activated, it increases the influx of potassium ions, which helps lower the transmission of the signals between neurons [18]. 


The working mechanism of Carisoprodol

Carisoprodol is a centrally-acting skeletal muscle relaxant that does not function by directly relaxing the muscle. Animal studies suggest that the muscle relaxation effect of the Soma pill is by altering the interneuronal activity in the spinal cord, thus preventing the pain signals from reaching the GABA receptor of the brain. 

Carisoprodol metabolizes in the liver to form Meprobamate (primary metabolite) and is believed to be responsible for the therapeutic effects of the muscle relaxer. The kidney excretes Carisoprodol and Meprobamate and has a half-life of 1.7 to 2 hours [19].


Dosage Guidelines 

Baclofen is available as 5 mg, 10 mg, and 20 mg oral tablets. It is also available as injections of 0.5 mg/mL, 2 mg/mL, 1 mg/mL, 0.05 mg/mL, and 5 mg/mL.

5 to 20 mg of Baclofen can be taken 3 times daily, which should be taken 6 to 8 hours apart. 


Baclofen Dose for Spasticity-

  • Initial Dose- Beginners should start with 5mg of Baclofen for the first 3 days, then 10 mg for the next 3 days, followed by 15 mg and 20 mg every 3 days. 

  • Maximum dose- 80 mg per day. 


Intrathecal Baclofen dose-

  • First Screening Dose: 50 mcg.

  • Second Screening Dose: 75 mcg if no positive result is seen from the first dose.

  • Third Screening Dose: 100 mcg for patients who do not respond to the above two doses [20]. 


Overdosing on Baclofen- 

Overdosing on Baclofen can cause coma, respiratory depression, seizure, lack of tendon reflexes, hypothermia, cardiac abnormalities, and bradycardia [21]. 


The two strengths of Soma pills commonly prescribed by doctors are 350 mg and 500 mg. The lower dose of the Soma pill (Soma 350 mg) is recommended for beginners. It can be gradually increased to 500 mg depending on the pain's severity and cause. 

The Soma pill can be taken thrice daily and once before bed, with a dosage gap of 5 to 6 hours. 


Overdosing on Soma pill-

The maximum dose of Soma recommended in a day is 1400mg. Overdosing on the muscle relaxer can cause potential health risks. 

Long-term and overdosing can cause abuse or dependency. Soma overdosing symptoms include hallucinations, vision issues, shallow breathing, muscle stiffness, rapid heartbeat, fainting, confusion, lightheadedness, and convulsions [22]. 



Baclofen can be taken orally by mouth, transdermally, and intrathecally through pump infusion. 

  • The tablets can be directly swallowed with water. 

  • Physicians often administer intrathecal Baclofen through a specialized pump implanted under the abdomen's skin. 

  • Transdermal use of Baclofen is through patches containing the muscle relaxer in gel or adhesive form. It is absorbed through the skin into the bloodstream. 

Similarly, the Soma pill can also be taken orally by directly swallowing. 

  • It should be taken as a whole without breaking or crushing it. 

  • The intake of the Soma pill is not recommended over three weeks of continuous use. 

  • Its administration is possible before or after having a meal. 

Duration Of Action

The duration of action of both the Soma and Baclofen pills is 4 to 6 hours [23]. 

It is, however, essential to note that the duration of action of both muscle relaxers may vary depending on factors such as metabolism, medical conditions, and dosage. 

User Review and Testimonials

The review of the Baclofen and Soma pill indicates its effectiveness, ease of use, and potential health risk experienced by users from short-term or long-term use of the muscle relaxers. This Baclofen and Soma review is based on the information obtained from two popular and trusted medical websites, Drugs and WebMD [24,25,26,27]. 


Bacfolen Review 

The Baclofen rating on the website Drugs is 6.9 out of 10 from a total review of 407. Most reviews (61%) reported a positive experience, while 24 % reported a negative experience. 

On the other hand, It has a rating of 3.5 out of 5 on WebMD. 



Soma Pill Review 

The average rating of Soma Pill on Drugs is 9.0 out of 10 from 289 reviews. About 89% of users suggest experiencing a positive effect, whereas about 7% report a negative experience. 

Based on its user experiences, the medical team of WebMD has rated Carisoprodol with 4.2 out of 5, which is further broken down as 4.5 ratings for effectiveness, ease of use, and user satisfaction. 




Baclofen Vs Soma High: A Case Report Of Their Abuse Potential 

According to a survey, about 15,397 cases of Baclofen abuse was reported by US poison centers between the year 2014 to 2017. Overdosing on Baclofen or taking the muscle relaxer with other compounds or drugs can cause euphoria, which may be a key reason for its abuse potential. Such people take Baclofen with alcohol, opioids, and Amphetamines [28]. 

Taking Baclofen with sleeping pills, alcohol, other muscle relaxants, and tranquilizers can result in weakness, imbalance, drowsiness, and Dizziness [29]. 

The Drug Enforcement Administration suggests that about 6,500 cases of Carisoprodol were reported in the year 2012 by the American Association of Poison Control Centers. Moreover, the National Survey on Drug Use and Health in the year 2012 reported 3 million cases of recreational use of Carisoprodol at some point in their lives [30]. 

Co-administrating Carisoprodol with other medication can amplify the sedative effect of the muscle relaxer, thus contributing to its cause of abuse and dependency.



The Houston Cocktail - It is one of the most common forms of Carisoprodol abuse. Recreational users take the Soma pills in combination with alprazolam and hydrocodone. 

According to the National Institute on Drug Abuse (NIDA), this is one of the most common combinations for substance abuse [31]. 



The symptoms of Soma abuse include-

  • Flushing of the skin.

  • Euphoria. 

  • Agitation.

  • Loss of balance. 

  • Poor coordination.


Baclofen Vs Soma: Who Is An Affordable Choice?

The price of the Soma pill and Baclofen plays a key role in determining the right muscle relaxer. The cost of Soma 350 and 500 mg at Healthnaturo is $0.74. 

The price list of Baclofen, along with its brand medication, is listed below [32]. 


Intrathecal Solution


Package cost

Cost per unit

0.05 mg/mL



0.5 mg/mL


$6.49 – $10.33    

1 mg/mL


$12.51 – $20.19

Oral Liquid

5 mg/5 mL



Oral Tablet

20 mg



10 mg




Since the FDA approves both Soma and Baclofen pills for medical use, its cost is covered by most health insurance and medicare plans. 

The cost of the muscle relaxer listed here may vary from other sites as it depends on factors such as the pharmacy and the medication package. 


Precaution And Warning For Baclofen And Soma Pill

Following preventive measures can help reduce the risk of experiencing side effects and also help enhance the beneficial effects of the muscle relaxer. 

Baclofen Preventive Measures 

  • The Baclofen pill is not recommended for people with stroke and Parkinson's disease [6].

  • It is not approved for treating skeletal muscle spasms associated with rheumatologic disorders [6].

  • People with respiratory disease and urinary retention should take Baclofen with caution. 

  • Restrict the use of Baclofen if you have decreased Gastrointestinal (GI) motility, peptic ulcer disease, and GI obstructive disorders. 

  • People with schizophrenia, confusion, and psychotic issues can cause worsening of conditions.

  • Patients with a history of seizures should be constantly monitored. 

  • Before taking Baclofen, inform your pharmacist and doctor if you are allergic to any of the compounds present in the formulation of the medication. 

Carisoprodol (Soma) Pill Preventive Measures- 

  • People over 65 and below 17 years are not recommended to take the Soma pill without consulting a physician. 

  • Long-term use of the Soma pill over three weeks is not recommended as it can increase the risk of experiencing side effects and abuse potential. 

  • Inform your doctor about taking the Soma pill before surgery or tooth extraction. 


Soma Vs Baclofen: Side Effects And Health Risks

Soma and Baclofen pills can result in unwanted adverse effects due to improper dosing, administration, drug interactions, and health disorders. 

Not all the possible side effects of these muscle relaxers are reported by users. Following the preventive measures can help you avoid experiencing these symptoms. 

Side Effects Of Baclofen 

Baclofen is reported to cause nausea, weakness, paraesthesia, and somnolence, affecting 25% to 75% of patients [33]. The FDA (Food and Drug Administration) conducted clinical trials involving 175 patients to report the following side effects of Baclofen. 


Side Effects 




















Urinary Frequency





The other side effects (not listed on the table) categorized according to the body part they affect are listed below. 

  • Gastrointestinal- Dry mouth, abdominal pain, diarrhea,  taste disorder,  vomiting, and anorexia. 

  • Neuropsychiatric- depression, muscle pain, rigidity, blurred vision, epileptic seizure, hallucinations,   euphoria, slurred speech, tremor, coordination disorder, and nystagmus. 

  • Cardiovascular- chest pain, dyspnea, syncope, and palpitation.

  • Genitourinary- urinary retention, impotence, hematuria, inability to ejaculate, dysuria, and nocturia. 

  • Other- weight gain, ankle edema, rash, nasal congestion,  excessive perspiration, and pruritus.

Soma Pill Side Effects 

The most common side effects of Carisoprodol are headache, dizziness, and drowsiness. The package insert suggests that about 17% of muscle relaxers users experience sedation. 

Some of the adverse effects of taking the Soma pill based on the body part they affect are listed below. 

  • Cardiovascular symptoms- Facial flushing, Tachycardia,  syncope, and postural hypotension. 

  • Psychiatric- insomnia, Agitation, depressive reactions, and irritability.

  • Gastrointestinal- epigastric discomfort, vomiting, nausea.  

  • Other- withdrawal,  Vertigo, and dependence. 

  • Hematologic- pancytopenia and Leukopenia. 

Consult a doctor immediately if you notice any of the below-mentioned side effects. These are serious health risks of the muscle relaxer, which are not very common in occurrence. 

  • Cardiac signs include fainting, faster heartbeat, and low blood pressure. 

  • Nervous system issues such as shakiness, depression, seizure, and trouble moving a muscle. 

  • Decrease in white blood cells (WBC) [34]. 


Possible Drug Interaction Of Soma Pill And Baclofen




The co-administration of the Soma pill and Baclofen with other medications and compounds can result in drug interaction, which can lower the efficacy of the muscle relaxers. They also increase the risk of experiencing side effects. 

Carisoprodol (Soma) Pill Drug Interaction

Some notable medications that should not be taken with the Soma pill are mentioned below. Co-administering them with Carisoprodol can elevate the risk of experiencing side effects.





Increases the Risk of side effects.


Decreases the metabolism of Carisoprodol.


Elevation of serum concentration of Carisoprodol. 

Acetylsalicylic acid

Increases the metabolism of Carisoprodol.


The therapeutic efficacy of Carisoprodol is increased. 


Decreases the metabolism of Formoterol.


The sedative effect of Carisoprodol increases. 


Increases the potency of side effects. 


Decreases the metabolism of Carisoprodol.

Naltrexone, Naloxegol

The severity of respiratory depression is increased.


Increases the risk of sedation, respiratory depression, hypotension, and somnolence. 

Ropeginterferon alfa-2b (Besremi)

The risk of neuropsychiatric effects can be increased.


Decreases the metabolism of Pentamidine. 


The central nervous system depressant (CNS depressant) activities of Zolpidem may increase. 


There are other possible drug interactions of the Soma pill apart from the ones mentioned here. Thus, it is essential to consult a doctor before taking any medication or supplement with Carisoprodol. 

Baclofen Drug Interaction 

Baclofen can interact with 359 known drugs to produce 26 major, 332 moderate, and 1 minor interactions. 

  • Alcohol- Taking Baclofen with alcohol can cause dizziness, weakness, and confusion. This combination affects the central nervous system to further cause lower blood pressure, poor concentration, slow speech, poor memory, coordination issues, and slow breathing. 

  • Benzodiazepines (Ativan, Xanax, and Klonopin)- These are medications that treat anxiety and panic disorders. Taking Baclofen with Benzodiazepines can slow your brain activity and cause shallow breathing. 

  • Opioids- In 2019, the FDA warned about the risk of taking Baclofen with opioids as they may cause serious side effects. 

  • Sleep medications- Medications such as Ambien and Unisom Sleep Tabs can cause excessive sleepiness if taken with Baclofen. It can thus affect your coordination and ability to complete daily tasks. 

  • Barbiturates- Taking Barbiturates such as phenobarbital and pentobarbital can increase the risk of drowsiness when taken with Baclofen. It may also cause confusion, breathing issues, and extreme sleepiness. 

  • Antipsychotic Drug- Administering medication such as Acetophenazine with Baclofen may increase Acetophenazine's central nervous system (CNS depressant) activities.

  • Antiarrhythmic medication- Co-administering Baclofen with Amiodarone can increase the risk of myopathy, myoglobinuria, and rhabdomyolysis. 

It is advisable to consult a doctor before any medication with Baclofen to avoid any possible health risks from drug interaction.


Baclofen vs Soma- Our Final Thought 

If you are still unsure which muscle relaxer is a better option for you, we have you covered. 

We summarize all our findings in this meticulously compared study of Robaxin vs. Soma. 

Soma pill and Robaxin are FDA-approved muscle relaxers effective for short-term acute pain. They both have similarities in their drug class, the onset of action, duration of action, and abuse potential. However, a few factors are notably different between the two. Thus, here is a glimpse of everything you should know before taking the Soma pill and Baclofen to make an informed decision. 





Begins to work in 30 minutes.

It is a more affordable option.

Off-label benefits of Baclofen include Alcohol use disorder (AUD), gastroesophageal reflux disease, and hiccups. 

Treats a wide range of body pain, including menstrual cramps and migraines. 

Has a broader dosing option. 

Soma pill is a better choice to treat fibromyalgia. 


Has quicker onset of action (within 30 minutes). 


Soma Pill has greater user reviews and ratings. 


It is a more expensive choice of muscle relaxer compared to the Soma pill.

Only available as oral tablets. 

Has a risk of abuse and dependency. 

Has a risk of abuse and dependency. 

Not recommended for pregnant or lactating women, children, and elderly people. 

Unsafe for elderly people, children, and Pregnant and lactating women. 

Has a lower user review and rating. 

Long-term use is not recommended. 

Long-term use of Baclofen is not recommended. 



Based on our analysis,

Carisoprodol or Soma pill is a better option for people looking for an effective muscle relaxer on a budget. With great user reviews, it is an effective analgesic that functions within 30 minutes of intake. 

Baclofen and Soma pill have similar health risks; thus, Baclofen cannot be used as an alternative option for Carisoprodol. Baclofen is, however, a better option for people with swallowing issues and who are looking for oral solutions and injections. 



Content Disclaimer - The conclusion drawn by our team on Baclofen vs. Soma muscle relaxer is completely based on analyzing the factors we have considered in this blog. 

Your physician may have a different recommendation based on your health condition. We advise all readers to consult a doctor before administering the Soma pill or Baclofen. 



Baclofen is not often recommended for muscle spasms other than those caused by multiple sclerosis, making the Soma pill (Carisoprodol) a better option.

It is not recommended to take Soma and Baclofen together. Co-administering them can increase the risk of experiencing confusion, dizziness, difficulty concentrating, and drowsiness.

Muscle relaxers such as Carisoprodol and cyclobenzaprine are considered a better option.

Yes, improper dosing and long-term use of Soma pills and Baclofen can cause addiction and withdrawal symptoms.

The onset of action of both Soma and Baclofen pills are 30 minutes.

Baclofen use is associated with side effects such as drowsiness, unsteadiness, dizziness, vision issues, and clumsiness.

It is safe to take Carisoprodol when taken in the right dose, and the administration guidelines mentioned by your physician are followed. However, the risk of abuse and dependency arises from long-term intake of the muscle relaxer.

No, Baclofen can only relax a certain muscle in the body. It effectively treats muscle tightness, cramps, and spine injuries.


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