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Robaxin Vs Soma: Choosing the Best Pain Treatment

Robaxin Vs Soma: Choosing the Best Pain Treatment


Soma vs. Robaxin comparison evaluates the most effective choice of muscle relaxer for your pain. 

Soma pill is a Carisoprodol brand medicine that works longer than Robaxin. It is also affordable and treats a broader range of pain symptoms. However, Robaxin or Methocarbamol is a better choice for people at a higher risk of experiencing dependency. 



Most people suffering from body pain wonder which among Soma vs Robaxin is a better choice of muscle relaxer. 

Suffering from body pain makes it very difficult to work and function well. The most commonly prescribed muscle relaxers are Carisoprodol (Soma pill) and Methocarbamol (Robaxin). While both of these muscle relaxers are effective in helping relieve body pain, they differ in their effectiveness, working mechanism, and health risks. 

So, this Robaxin vs. Soma guide takes an in-depth look at both muscle relaxers to help you understand the similarities and differences between the two and help you make an informed decision. 


Robaxin Vs Soma: Is Methocarbamol The Same As Soma

Soma pills and Robaxin are clinically proven and FDA-approved muscle relaxers that help relieve pain within 30 minutes of intake. 

  • Soma pill: Carisoprodol is available as a brand drug named Soma pill, which is an effective treatment option for short-term acute pain. In 2019, the Soma pill was the 343rd most commonly prescribed medication in the United States, with about 800 thousand prescriptions [1].

  • Robaxin: Methocarbamol is available under the brand name Robaxin, which is prescribed for treating short-term musculoskeletal pain.  It is available as both a generic and brand drug and was the 127th most commonly prescribed medication in the United States, with more than 4 million prescriptions [2]. 

These muscle relaxers are often recommended to be taken with rest and physical therapy for the best results. 



Soma Pill 


Generic name



Brand name

Soma pill, Prosoma, Carisoma, Pain o Soma.

Robaxin, Marbaxin. 


HAB Pharmaceuticals.


FDA approval

Yes, In 1959. 

Yes, In 1957. 

Legal Requirements or status

US: Schedule IV prescription drug.

Canada—Over the Counter.

UK- Prescription drug.

USA- Prescription Drug.

Class of drug

Skeletal muscle relaxant.

Skeletal muscle relaxant.

Structural differences




Active Compound: Carisoprodol and Aspirin.


Inactive Compounds- Stearic acid, hypromellose, croscarmellose sodium, microcrystalline cellulose, magnesium stearate, povidone, and starch [3]. 

Active Ingredient- 



Inactive Ingredients- 

Magnesium stearate,  Corn starch,  stearic acid, sodium lauryl sulfate, povidone, and sodium starch glycolate [4]. 


So, Is Methocarbamol A Soma?

Even though both Robaxin and Soma pills are both muscle relaxants, they are not the same. They are different drugs with different chemical structures and properties. 

Both muscle relaxers have different compositions and mechanisms of action, thus having varying effects and potential side effects.


Soma Vs Robaxin- A Detailed Comparison Of Their Uses And Benefits

Robaxin or Methocarbamol is used for treating muscle spasms [5]. It has limited use for treating cerebral palsy and rheumatoid arthritis. 

On the other hand, the clinical use of the Soma pill effectively relaxes muscles after an injury, sprain, or strain [1]. The use of Soma for menstrual cramps, lower back pain, migraines, and fibromyalgia is also effective. 

Soma Vs Robaxin For Back Pain

A clinical trial evaluating the effectiveness of Methocarbamol (Robaxin) for acute low back pain showed that 44% of the individuals taking the muscle relaxer experienced complete pain relief from back pain [31]. However, the use of Robaxin is less preferred for managing lower back pain [2].


According to two clinical trials that have been recognized and included by the FDA, the use of the Soma pill is also effective in treating back pain [32]. 

A double-blind study in 1972 compared the effectiveness of the Soma pill with butabarbital and placebo in treating low back syndrome, indicating the Soma pill (Carisoprodol) showed significant improvement compared to placebo and butabarbital [33]. 

Another paper published in the British Pharmacological Society journal in 2007 states that a Soma pill or Carisoprodol is recommended in Norway only for acute lower back pain [34]. 


Methocarbamol Vs Soma- An In-Depth Analysis Of Their Differences 




Although Soma and Robaxin are proven effective muscle relaxers, they differ in numerous factors. So, let us look at some of the notable differences between Robaxin and Soma pills to help you choose the right analgesic. 

How Do Soma Pills Work As A Muscle Relaxer?

The working mechanism of a drug suggests how a medication works to produce its therapeutic effect. In this case, we overview the muscle-relaxing properties of Robaxin and Soma pills. 

The mechanism of action of Carisoprodol (Soma pill) takes place in the liver. Carisoprodol is metabolized to meprobamate, which is its primary metabolite. It is a centrally acting muscle relaxant that doesn't work on the muscles directly. It is induced by altering the interneuronal activity between the spinal cord and the brain receptor. 

Mechanism Of Action Of Robaxin 

Meprobamate, the primary metabolite of Carisoprodol, is believed to target the GABA receptor of the brain. It is responsible for the therapeutic effects and the abuse potential of the Soma pill [6].

The working mechanism of Robaxin or Methocarbamol depends on its central nervous system. This action is mediated by-

  • Blocking the spinal polysynaptic reflexes.

  • Decreasing the transmission between the spinal cords.

  • Increasing the refractory time of the muscle cells [7]. 

Duration Of Action

The Soma pill's effects last 4 to 6 hours [11]. In comparison, the effect of Robaxin may last up to 4 to 5 hours [3]. 


Carisoprodol Vs Methocarbamol Dosage Guidelines 

Taking the correct dosage is essential to getting the best benefit from the muscle relaxant and avoiding all potential side effects. 

Soma pill Dosage

The Soma pill is available in two strengths- Soma 350 mg and Soma 500mg. Beginners are prescribed Soma 350 mg, which can be increased to 500 mg depending on the condition and the severity of the pain. 

- Soma Pill Dosage Guidelines

  • The maximum Soma dosage is 1400 mg a day.

  • Number of Soma doses in a day- 3 to 4 pills (thrice in the morning and once before bedtime). 

  • Dosage Gap- 5 to 6 hours. 

- Dosage Modification Recommended For People With Hepatic And Renal Disorders 

Patients with reduced CYP450 2C19 activity or liver functioning should use the Soma pill with caution as they have a higher risk of exposure to carisoprodol and lower exposure to meprobamate. 

Soma Overdosage

Taking a dose more than recommended can result in overdosing. So, avoid taking more than 1400 mg of Carisoprodol in a day.

Symptoms of Soma overdosage include:

  • Fainting

  • Hallucination

  • Shallow breathing

  • Palpitation

  • Muscle stiffness

  • Vision Issues

  • Lightheadedness

  • Confusion.

Robaxin Dosage Guidelines

 Robaxin is available in three strengths- Robaxin 500mg, 750 mg, and 1000mg. Beginners should start with a lower dose of the muscle relaxer, such as 500mg or 750mg. 

  • Maximum Dosage- 6000 mg per day for the first 48 to 72 hours. This can be followed by 8g per day (8000 mg) in the following days for severe pain [8]. 

  • Number of doses in a day- 4 times a day. 

  • Dosage Gap- 6 hours. 

Robaxin Overdosage

Overdosing on Methocarbamol is often done with CNS depressants and alcohol, resulting in blurry vision, coma, blurry vision, hypotension (low blood pressure), nausea, seizures, and drowsiness. 


Methocarbamol Vs Soma- Safe Administration 

The right administration of Soma and Robaxin medication helps to ensure the best benefits while minimizing the risk of side effects. 

Soma pill Administration

  • The Soma pill should be taken orally with plain water.

  • It should not be crushed or broken before use. The snorting of Soma pills is not recommended. 

Robaxin Administration

Robaxin is available as oral pills and injections so that it can be swallowed with water or taken intravenously or intramuscularly [35]. 

  • Oral Intake: The Robaxin tablets should be taken by mouth as a whole without breaking or crushing with plain water. 

  • Intravenous Administration: It can be taken undiluted by direct IV injection at a maximum rate of 300 mg per minute. 

  • Intramuscular Intake: Robaxin can be taken undiluted intramuscularly. The maximum dose is 500 mg for each gluteal region (region of the buttocks). 


Soma Vs Robaxin Effectiveness- Is Methocarbamol Stronger Than Soma

Soma and Robaxin both exhibit a similar onset time for their therapeutic actions. They both take 30 minutes to start acting. 

A 2004 systematic review suggests that the Soma pill is comparatively more effective for treating acute back pain than a placebo, whereas Robaxin has very limited or inconsistent data [9]. 

Another study by Michele M Spence (Clinical Pharmacy Research Scientist) evaluates the risk of injury associated with skeletal relaxants in older adults. It shows that both Carisoprodol and Methocarbamol are associated with increased health risks for people 65 years of age or older [10].  

However, there is no definitive answer to which of the Robaxin vs. Soma pills is more effective for treating body pain. Their potency may vary depending on individual factors, such as the severity of the pain, its cause, and the medical history of the patient. 

Soma pill can, however, treat wider causes of body pain compared to Robaxin. 


Soma And Robaxin- Potential For Abuse

According to a study by Charles Dillon, approximately 2 million American adults reported muscle relaxant use [36]. This prevalent use potentially increases the risk of misuse, thus leading to Soma and Robaxin dependency. 

Understanding Robaxin Abuse Potential

A clinical trial by a team headed by K L Preston (Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine) suggests that Robaxin has a lower risk of abuse. However, people with a history of substance abuse may be more likely to misuse the muscle relaxer [12].




Taking Robaxin with substances such as alcohol or other additives can cause dependency and increase the likelihood of experiencing side effects [13]. 

Taking a higher dosage or frequent dosing may be a sign of misuse. The main reason for misusing Robaxin is its ability to act as a central nervous system depressant that may result in drowsiness and slowed reaction time [14]. 

It is, however, essential to note that the use of Robaxin does not cause a feeling of euphoria, thus lowering its risk for abuse. Symptoms of Methocarbamol addiction and abuse [15]: 

  • Taking larger doses than prescribed.

  • Recreationally taking the Robaxin dosage.

  • Co-administering it with alcohol or other substances.

  • Visiting multiple doctors for prescriptions. 

  • Having cravings for Robaxin. 

  • Withdrawal from friends and family. 

Assessing The Abuse Potential Of Soma Pill 

Soma pill is a schedule IV controlled substance and thus has a lower potency for abuse and dependency [16]. 


However, the Dallas DEA Field Division states that Carisoprodol is one of its region's six most commonly abused medicines. Further, the U.S. Department of Justice Drug Enforcement Agency Office of Diversion Control website suggests the widespread abuse potential of the muscle relaxer [17]. 


So, what makes Soma addictive?

Most people abuse the Soma pill for its sedative, euphoric, and relaxing effects [18]. Meprobamate, the primary metabolite of Carisoprodol, is proven to have habit-forming effects similar to benzodiazepines [19]. 

Signs of Soma abuse include-

  • Flushing of skin.

  • Insomnia

  • Seizure

  • Impaired physical Coordination.

  • Palpitation or rapid heart rate.

  • Appearance of being drunk or Euphoria.

  • Dizziness

It also has a social impact on the person, resulting in

  • Unable to think clearly.

  • Signs of depression.

  • Agitation.

  • Irritability.

  • Withdrawal from friends, family, and most social activities. 

  • Looking for ways to get a Soma pill.

Soma (Carisoprodol) Abuse in Teens

Prescription drug use and abuse are a concern among teens, as these substances can often be perceived as less threatening than most illicit drugs. 

A 2020 study on Carisoprodol abuse in Adolescence suggests that substance use disorder is common in adolescents with psychiatric disorders. The study indicates no case reports of Carisoprodol abuse in teens. It suggests that prescription medications should be kept out of their children's reach to decrease the risk of accidental abuse by teens and children. Focusing on educating children on substance abuse is also a great way to prevent it [20]. 

Soma Abuse: Has Anyone Ever Tried The Holy Trinity? 

'The Holy Trinity' is a drug combination that includes an opioid, Carisoprodol, and benzodiazepine.  According to a survey in Florida, approximately 17,000 people were prescribed this combination in 2017 alone.

The holy trinity is not recommended and may be dangerous as it potentially combines all their health risk. 


Methocarbamol Vs Carisoprodol- User Review 

Robaxin vs. Soma pill reviews indicate their effectiveness and user experiences to help us draw a better conclusion of which among the two is best suited for you. 




The Medical Review Board on the website Drugs, on the basis of 193 reviews, gives Soma pill a rating of 9.2 out of 10. 

92% of the reviews suggest experiencing a positive effect from the muscle relaxer, whereas 5% report a negative experience [21]. 

On the other hand, Robaxin has an average rating of 6.2 out of 10 on the same website, based on 71 reviews. About 53% of people report experiencing a positive benefit, whereas 31% report experiencing a negative effect [22]. 




According to WebMD, the Soma pill has a rating of 4.1 out of 5 based on its effectiveness, satisfaction, and ease of use. In contrast, Robaxin has a rating of 3.4 [23,24]. 


Coverage And Cost Comparison Of Soma And Robaxin

The FDA approves the clinical use of both the Soma pill and Robaxin; thus, most Medicare plans and health insurance cover the cost of these muscle relaxers. 

Robaxin 750 mg for 20 tablets is $80, which is $4.04 per pill [25]. On the other hand, the cost of Soma 500 mg is $298 for 400 pills, making it $0.7 per pill at HealthNaturo. 

The price of both muscle relaxers, however, may vary depending on the pharmacy, available discounts, and pill package. 


Preventive Measures And Warnings Before Taking Soma And Robaxin

  • The long-term use of both Soma and Robaxin should be done under the supervision of a physician. 

  • Do not use these muscle relaxers if you are allergic to any of the compounds present in their formulations. 

  • Robaxin and Soma pills can cause dizziness or drowsiness, making driving or using heavy machinery unsafe. 

  • Mixing alcohol with Soma and Robaxin can cause CNS depression and is not recommended. 

  • Muscle relaxers can affect the heart, causing palpitation; thus, they should be administered after consulting a doctor.

  • Avoid taking these muscle relaxers if you have kidney or liver disorders. 

  • Pregnant and lactating women are advised not to take Robaxin and Soma pills without consulting a physician. 

  • Older adults over 65 are more likely to suffer side effects from these pain medications. 

  • Before surgery, informing your doctor about using the Soma pill and Robaxin is essential. 

Additional Soma warning

Do not stop taking the Soma pill abruptly, as it may cause withdrawal signs. It is best to consult a physician before stopping the Soma pill. They will gradually decrease the dose before completely stopping it. 


Side Effects Of Soma And Robaxin

Along with the beneficial effects of these muscle relaxers, they can also result in adverse effects under certain conditions. Health conditions, improper dosing, and administration often result in side effects [26,27]. 

What Are The Side Effects Of Pain O Soma 350mg?

Pain O Soma, the brand name of Carisoprodol, is known to be a safe medication with a lower risk of side effects. However, the use of the muscle relaxer can result in the following health issues. 

  • Irritability

  • Upset Stomach

  • Nervousness

  • Agitation

  • Hiccups

  • Depression

  • Dizziness

  • Vomiting

  • Headache

  • Insomnia


Soma pill Side Effects 

Robaxin Side Effects 


Stomach Upset

Upset Stomach

Blurred Vision












Stuffy Nose






Long-Term Effects Of Soma And Robaxin Use

The long-term use of Robaxin is not recommended. The chronic use of Methocarbamol is indicated to cause suicidal thoughts [15]. However, a study suggests that Robaxin can be taken at 10 mg/kg for long-term use. 

On the contrary, the long-term use of the Soma pill is not recommended. It can result in abuse and addiction if taken over three continuous weeks. 


Potential Drug Interaction Of Carisoprodol And Methocarbamol




Co-administering Soma and Robaxin with other medications can cause drug interactions that may lower the effectiveness of the medicine, along with increasing the risk of experiencing side effects. 

Soma Drug Interaction 

The Soma pill can interact with 350 medications, causing 27 major, 322 moderate, and 1 minor health issues. Avoid taking the Soma pill with the following medications, which can cause serious side effects [28]. 

  • Oxycodone- It is a potent opioid that may cause respiratory depression, coma, or death if taken with the Soma pill. This interaction can also increase the addictive effect of both muscle relaxers if taken for an extended period or in large doses. 

  • Methadone- Taking Carisoprodol with Methadone can cause severe CNS and respiratory depression. 

  • Buprenorphine- Taking them together can cause respiratory and CNS depression.

  • Promethazine- It can result in respiratory depression and loss of consciousness. 

  • Vicodin- Taking Soma and Vicodin together is common for abuse as their combined effect is similar to heroin [29]. However, taking them together can cause dizziness, drowsiness, difficulty concentrating, lightheadedness, and impaired judgment [30]. 

The following drug combinations with the Soma pill can cause moderate Soma Interaction. 

  • Hydrocodone- Taking a Soma pill with Hydrocodone reduces the effectiveness of Carisoprodol. 

  • Gabapentin- Taking Carisoprodol in combination with Gabapentin can worsen the sedative effect of both medications. It may also elevate the addictive effect of the muscle relaxer. 

  • Omeprazole- This drug affects the metabolism of Carisoprodol in the liver, thus prolonging its excretion time from the body. Therefore, it increases the effect of the muscle relaxer on the Central Nervous System and extends its detection time in Soma drug tests. 

It is important to note that this is not a complete list of all the medications that can interact with Carisoprodol but some of the most common interactions of the muscle relaxer. So, if you are undergoing any treatment, it is best to consult a doctor before co-administering the Soma pill. 

Robaxin Drug Interaction

About 328 medications are known to interact with Robaxin. Some of the common interactions of Methocarbamol are listed below. 

  • Acetophenazine- Co-administering Robaxin with Acetophenazine can increase the risk of experiencing side effects. 

  • Perampanel- It may increase the CNS depressant activity of Robaxin, causing dizziness or drowsiness.

  • Rotigotine- The sedative effect of Rotigotine increases when taken with Robaxin.

  • Pyridostigmine- Taking this medicine with a muscle relaxer can reduce the therapeutic efficacy of Pyridostigmine.

  • Lofexidine- Taking Robaxin with Lofexidine increases the therapeutic efficacy of the muscle relaxer. 

  • Naltrexone- Increases the severity of respiratory depression. 

  • Opioids (Oxycodone, Methadone, Hydrocodone, acetaminophen)- Taking Robaxin with opioids is considered risky. The FDA warns against the use of opioids with other medicines that affect the brain as it may cause serious side effects. 

  • Benzodiazepines- Combining Benzodiazepines with Methocarbamol can cause dizziness, risk of overdosing, oversedation, and drowsiness. 

  • Alcohol- Robaxin and Alcohol affect the body similarly, causing similar effects. So, it is best to avoid combining these two. Robaxin interaction with alcohol can cause overdosing. 

A case report suggests a fatal drug interaction caused by taking alcohol with Methocarbamol (Robaxin). It causes acute alcohol intoxication, resulting in central nervous system depression.

Robaxin can interact with other medications apart from those listed here. So, it is best to consult a doctor before co-administering the muscle relaxant with other compounds and drugs. 


Can You Take Robaxin And Soma Together?

Taking the Soma pill with Robxin can result in moderate drug interaction. Combining them can result in drowsiness, difficulty concentrating, dizziness, and confusion. 

Elderly people taking Robaxin with the Soma pill may experience impaired judgment-making, thinking ability, and motor coordination. 


A Conclusion On Which Is Stronger, Robaxin Or Soma?

Still wondering which is more effective, Robaxin or Soma? Let us summarise it for you. 

Soma pill and Robaxin are two effective muscle relaxers that the FDA approves for treating short-term skeletomuscular pain. 

Both Soma (Carisoprodol) and Robaxin (Methocarbamol) have numerous similarities as they belong to the same drug class (muscle relaxants). However, their structure, active ingredients, pricing, effectiveness, user ratings, and clinical benefits differ. 

To help you make an informed decision in this Soma vs. Robaxin debate, we have summarised the pros and cons of the two muscle relaxers. 


Soma pill 



  • Works within 30 minutes of intake.

  • It is cheaper and more affordable compared to Robaxin.

  • Soma Pill has a higher user review and rating. 

  • Mild to moderate side effects.

  • It has a longer action time compared to Robaxin. 

  • It can be administered 3 to 4 times a day. 

  • Treats a wider range of pain. 

  • It takes 30 minutes to act.

  • Lower risk of abuse. 

  • The chances of experiencing withdrawal signs are low. 

  • A physician may recommend long-term use. 


  • Higher risk of abuse.

  • Abrupt discontinuation of the drug can cause withdrawal symptoms.

  • Long-term use is not recommended.

  • Not for people above 65 years or below 17 years.  

  • Unsafe during pregnancy and breastfeeding women. 

  • It is costlier than the Soma pill. 

  • Robaxin review is low, showing unsatisfactory treatment.

  • Lesser time of action compared to Carisoprodol.

  • Only recommended for muscle pain. 

  • Not recommended for elders and children below 17 years. 

  • It does not stay in the system for long, requiring multiple dosing. 

  • Its use is not recommended for pregnant and nursing mothers. 


In our opinion, The soma pill is a better choice for a muscle relaxer if you are on a budget or looking for a more potent analgesic that treats a wide range of pain. 

People with a history of abuse or more likely to experience dependency should take Robaxin.


Content Disclaimer - 

It is important to note that our conclusion on the Soma vs. Robaxin comparison is based on analyzing the factors we have considered in this blog. 

Depending on your health and other medical factors, your physician’s option on the right muscle relaxer between the two may vary from us. Thus, we encourage you to consult a healthcare professional before taking either the Robaxin or Soma pill. 



Soma pill can be a better analgesic choice over Robaxin as it is more effective and affordable. However, people also may take Fexmid and Amrix as they need to be administered once a day.

Soma pill and Robaxin are both muscle relaxers and thus work similarly. However, Soma is known to cause sedation and a feeling of euphoria, which is not experienced while taking Robaxin.

Robaxin ( Methocarbamol) and Soma pill (Carisoprodol) may differ in dosage, cost, effectiveness, user review, and abuse potential. 

  • Soma pill is available as oral tablets, whereas Robaxin is available as injections and tablets. 

  • The cost of the Soma pill is cheaper than Robaxin.

  • The analgesic effect of the Soma pill last longer than Robaxin. 

  • Soma pill has a better and higher rating than Robaxin. 

  • The abuse potential of the Soma pill is higher. 

Some effective alternatives for Robaxin are the Soma pill, Zanaflex, and Cyclobenzaprine.

Some potential Carisoprodol (Soma) alternatives are Diazepam, Baclofen, Robaxin, and Valium.

Even though Robaxin 500mg may work similarly to Soma 500 mg, they may differ in the time of action and abuse potential. Soma 500mg will work longer compared to Robaxin however it also has a higher risk of abuse.

Soma and Robaxin should be taken together as they are both muscle relaxers with similar mechanisms of action. Taking them together may increase the risk of experiencing side effects.

Both Soma pills and Robaxin are prescription drugs and unavailable over the counter. However, Robaxin is sold as an OTC drug in Canada.

Both Soma and Robaxin muscle relaxers are effective analgesics that help treat short-term acute pain in 30 minutes. The action of the Soma pill however lasts longer than Robaxin and is also available at an affordable price.


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