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Palexia 100mg- A study on its similarities to Tapentadol

Palexia 100mg- A study on its similarities to Tapentadol

Palexia 100mg is a trading name of the popular opioid analgesic Tapentadol. The rise in pain medication's popularity is due to its high efficacy and potency in treating severe and sharp pain. Tapentadol is the only schedule II drug incorporating a dual mode of action. It makes using the opioid analgesic and its brand version, Palexia, effective against a broad spectrum of pain. So, people wondering about the similarities between Palexia 100mg and Tapentadol, we have you covered. This blog focuses on getting Palexia online and conveying basic information on the uses, warnings, and reviews of the product.


Palexia 100mg product information

Active compound

Tapentadol hydrochloride

Other compounds in the formulation

Each tablet contains 58.24 mg tapentadol hydrochloride with Microcrystalline cellulose, Lactose, monohydrate, Croscarmellose sodium, Povidone, and Magnesium stearate

Tablet coating

Polyvinyl Alcohol,Titanium dioxide and Macrogol 


Grünenthal Ltd

Product category

Opioid pain medication


Severe chronic pain


Schedule II in the USA 

S8 controlled drug in Australia


3 years


Tapentadol mechanism of action- How quickly does Palexia medication work?

Tapentadol works by acting on the CNS of the body. The analgesic has a dual mechanism of action that works on the opioid receptor and norepinephrine inhibitor. The onset of the action takes 30 minutes after administration in the form of tablets. The half-life of Palexia medication is 4 hours, and the analgesic's action lasts 5 to 6 hours. The analgesic metabolism begins in the liver, and the kidney carries out excretion. Palexia follows a first-order elimination process; primarily, the elimination from the body is through urine [1]. 

What type of pain does Palexia 100mg help?


What type of pain does Palexia help?


Palexia medication's prescription is for treating acute and chronic pain. Palexia reviews indicate its effectiveness for treating body pain occurring from musculoskeletal pain, fractures, cuts and injuries, diabetic neuropathy, fibromyalgia, etc. Tapentadol is a prescription drug, so take it after consulting a doctor. 

Palexia dosage and administration

The administration of Palexia 100mg is similar to Tapentadol. It is an oral drug, and so take it by the mouth. The standard dose of Palexia is 100mg. However, beginners can start with a lower dose of the analgesic. Gradually, the dose can be increased depending on the severity and cause of the pain.


Facts to check before administering Palexia medication

  • Check if you are allergic to Tapentadol or any of the ingredients in the formulation.

  • Ensure you do not suffer from shallow breathing problems

  • A healthy gut

  • No evident kidney, liver, or heart disorder 

  • Lactose intolerance 

Tapentadol (Palexia) dosage information


Route of administration


Available doses form

Tables and oral solutions


Palexia 50mg. 100mg and 150mg

Formulation of doses 

Palexia SR and IR

Dosage gap

4 to 6 hours for Palexia IR and approximately 12 hours for Palexia SR

  • Take Palexia medication as a whole without being broken or crushed. 

  • Do not take it for more than three continuous uses. The long-term use of Palexia 100mg can elevate the chances of dependency and addiction in the user. 

  • One can take the Palexia IR dose 3 to 4 times daily. In comparison, the administration of Palexia SR is twice a day. 

  • Palexia reviews show that heavy meal intake can affect the analgesic's efficacy. Thus, one can take a light meal with or before the intake of the Tapentadol pain medication.

 How much Palexia can you take per day?

The maximum dose of Palexia on the first day of treatment is 700mg. However, the daily dose of Tapentadol is 600mg. Overdosing on the analgesic is not advisable and can escalate the chances of side effects. 


 How long can you take Palexia IR?

Palexia reviews and FDA approves the use of Tapentadol for three weeks continuously. Long-term use of the analgesic can cause dependency and addiction in the user. 


 Can you just stop taking Palexia?

The abrupt discontinuation of the Palexia medication is not advisable. Unsupervised adjustments of the Palexia dose are also not advised. Palexia reviews indicate that such practices can cause withdrawal symptoms in the user.  


 Can you drive while taking Palexia 100mg?

Palexia 100mg can cause dizziness and sleepiness in the user. It can also trigger symptoms of nausea and vomiting. So, one should not drive immediately after taking Palexia dosage. 


 Can missing a dose of Palexia trigger withdrawals?

The chances of Palexia withdrawal signs from missing a dose are low. Palexia reviews exhibit that people on higher analgesic doses may experience minor discomfort when missing a dosage. Such people can take the missed dose later in the day to ensure minimum side effects from the analgesic.

Are Palexia and Tramadol similar?

Palexia and Tramadol are opioid analgesics and belong to the Benzenoid drug class. According to a study by David R P Guay, the use of Tapentadol overcomes some of the liabilities of Tramadol [2]. The effectiveness of Tramadol is much weaker than that of Tapentadol [3]. Thus making Palexia 100mg a better analgesic choice over Tapentadol for treating body pain.

Palexia Warning- Let your doctor know 

Tapentadol is not advisable under certain conditions as it potentially increases the chances of side effects in the user. Before taking Tapentadol doses, it is essential to let your doctor know the following health factors. 

  • If you have a head injury or brain tumor. 

  •  For people with Epilepsy. Using Palexia can increase the risk of seizures. 

  • Suffering from a biliary tract or pancreatic disorder 

  • People with increased pressure in the brain 

  • Asthma and other breathing problems 

  • Users above the age of 65 years and below 17 years 

  • If you have a history of abuse 

 Tapentadol and pregnancy 

Palexia 100mg is not for pregnant women who are lactating or planning to get pregnant. Palexia reviews show prolonged use of the analgesic during pregnancy can cause withdrawal signs in the infant [3]. Recognizing these signs is vital for avoiding life-threatening disorders in the newborn child. Thus, the opioid analgesic during pregnancy can further cause shallow breathing in the baby.


 Operation of a heavy machine with Tapentadol 

Palexia can cause dizziness, blurry vision, and drowsiness in people. These signs are more frequent in beginners. Therefore, using heavy machinery, driving, and other equipment is not advisable after taking Tapentadol.

Palexia abuse and dependency 

Tapentadol abuse is typical for its Somnolence and euphoric effects. It can develop a controlled urge to take the analgesic all day long. Such people experience discomfort when not under the influence of the medication. However, the chances of Palexia are low.

Palexia abuse and dependency

A study by Manuel J. Sánchez del Águila et al. shows the possibilities of dependency and abuse of Tapentadol with other opioid pain medications [5]. This study reveals that Tapentadol exhibits the lowest potency for abuse compared to Tramadol, Hydrocodone, and Oxycodone. Some of the noted signs of Tapentadol dependency are-

  • Social withdrawal

  • Buying Palexia without a prescription

  • Anxiety 

  • Mood swings and depression 

  • Taking dose more than advised 

  • Visiting several doctors for multiple Tapentadol prescription 

Tapentadol (Palexia) drug interaction

Tapentadol has a low potency for drug interactions. In a study by NCBI, there were no significant changes in the plasma concentration of Tapentadol when taken with aspirin, paracetamol, and naproxen. This study also indicates no drug interaction with metoclopramide, probenecid, and omeprazole. However, it may react with certain compounds and medication to lower the efficacy of the analgesic. Some medicines that may potentially respond with Tapentadol are codeine, cough medications, MAO inhibitors, birth control pills, anti-anxiety drugs, antidepressants, etc. People under any treatment and medication should take Palexia after consulting a physician.


 Can you drink alcohol with Palexia?

The use of alcohol with Tapentadol is not advisable. These interactions can cause alcohol tolerance and elevate the chances of side effects. Mixing alcohol with Tapentadol may also cause dizziness and drowsiness in the user. It is advisable to avoid the intake of alcohol for about 6 to 7 hours after taking Palexia IR and 1bout 14 hours after taking Palexia SR.


Is Palexia a Schedule 8 drug?

Palexia is a Schedule S8 drug in Australia. It is not available over the counter and requires a valid medical prescription. However, one can get Palexia online without a prescription. 


What's the street price for Palexia?

Tapentadol is available at Healthnaturo at $2.77 per pill. However, there are additional offers and discounts on all first orders.

Palexia side effects

Tapentadol is a highly tolerated analgesic, thus with a lower potency to cause side effects. It makes the non-prescription use of Palexia very common. Palexia side effects


The above graph from clinical therapeutics shows that the chances of side effects are much lower in Tapentadol compared to other strong opioid pain medications [5]. These signs and symptoms may appear in users under the following circumstances: overdosing, drug interactions, other medical conditions, and improper drug administration. 


Adverse effects on the body


Very common




Metabolism and nutrition disorder


Decrease in appetite



Immune system disorder




Drug hypersensitivity

Nervous system issue

Headache, dizziness, and Somnolence


Memory impairment, involuntary muscle contractions, lack of attention, Presyncope, Paraesthesia, sedation

Abnormal coordination, convulsion

Psychiatric disorders


Abnormal dreams, anxiety, hallucination, confusion, sleep disorder, Hallucination

Agitation, nervousness, disorientation, mood swings, depression, euphoria, restlessness

Abnormal thinking

Gastrointestinal disorders

Vomiting and Nausea

Diarrhea, constipation, dry mouth

Abdominal discomfort

Impaired gastric emptying

Respiratory disorder



Respiratory depression, Dyspnoea, decrease in oxygen saturation.


Vascular disorders



Decrease in blood pressure.


Cardiac dysfunction



Increase in heart rate, palpitation

Decrease in heart rate.


It is crucial to note that this is not the complete list of all the Palexia side effects. However, these are mild signs and do not require immediate medical help. In case of persistent discomfort, consult a physician and discontinue the use of the analgesic. 


Does Palexia 100mg make you sleepy?

One of the common side effects of Tapentadol is drowsiness. Thus, the Palexia review shows that most people feel sleepy after taking the analgesic. However, this effect doesn't last long and goes away in a few hours.


  1. Tapentadol hydrochloride: A novel analgesic, Dewan Roshan Singh et al, The National Center for Biotechnology Information. 

  2. Is tapentadol an advance on tramadol?, David R P Guay, Pubmed

  3. Is Tapentadol a Glorified Tramadol?, Practical pain management

  4. Palexia 50 mg film-coated tablets, medicines.org.uk

  5. Practical Considerations for the Use of Tapentadol Prolonged Release for the Management of Severe Chronic Pain, clinicaltherapeutics.