Enjoy an Exclusive 2% Discount on Your First Purchase of Selected Medications -Shop Now!

Customer Support

Modafinil Vs Vyvanse: A Comprehensive Comparison

Modafinil Vs Vyvanse: A Comprehensive Comparison


Modafinil vs Vyvanse comparison suggests Modafinil is a better, affordable, and safer treatment option for Excessive daytime sleepiness, chronic fatigue, mood swings, and cognition. In contrast, Vyvanse is a better therapeutic option for managing signs of ADHD. 



In today's fast-paced world, the demand for cognitive performance has rapidly increased the popularity of Nootropics among individuals. Nootropics are stimulants known to enhance focus, productivity, and cognitive performance. 

Modafinil and Vyvanse are two popular medications known for their cognitive-enhancing effects. Even though both have quite a few similarities, they also have notable differences that one should be aware of before starting the treatment regimen. 

This blog aims to provide a comprehensive comparison of Modafinil and Vyvanse, exploring their mechanisms of action, efficacy, uses, and side effects.


Modafinil And Vyvanse- An Overview

Modafinil is a psychostimulant with cognitive and alertness-promoting properties. The FDA approved it in 1998 to treat daytime sleepiness in patients with narcolepsy. Its mechanism of action involves enhancing brain chemicals, also known as neurotransmitters.

Vyvanse is a central nervous system stimulant (CNS) approved by the FDA in 2007 for medical use. This medication is primarily recommended for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and binge eating disorder or compulsive overeating. Vyvanse is a prodrug that undergoes conversion into dextroamphetamine in the body, leading to its stimulant effects that primarily influence neurotransmitter levels in the brain.


Modafinil Vs Vyvanse Comparative Analysis

A detailed comparative analysis of Modafinil and Vyvanse based on various factors is mentioned below:





Generic and Brand Name 

Generic Modafinil is available in numerous brands, such as Modalert, Modvigil, and Provigil. 

The generic name of Vyvanse is Lisdexamfetamine.

Drug class

CNS stimulant.

CNS stimulant.

Controlled substance Schedule

Schedule IV controlled substance.

Schedule II.

Pregnancy Category

Modafinil is a pregnancy Category C drug.

Pregnancy Category C.


It is effective in treating narcolepsy, shift work sleep disorder, and obstructive sleep apnea by promoting wakefulness and alertness. Its off-label use for enhancing cognitive function, focus, and fatigue is also widely recognized.

They are primarily prescribed for ADHD and binge eating disorder. Vyvanse also improves attention, cognitive performance, concentration, and impulse control.


The standard dose of 200 mg Modafinil is available as an oral tablet.

The standard recommended dose is 30 mg. It is available as oral capsules and chewable tablets.

Duration of Effect

It works within 30 minutes, and efficacy lasts 12 to 15 hours.

The onset of action is 1 hour and lasts for 10 to 12 hours. 

Side effects

  • Headache

  • Nausea

  • Nervousness

  • Insomnia

  • Nausea or vomiting

  • Decreased appetite Headache

  • Stomach pain

Age restrictions

Adults above 17 years can use Modafinil.

Vyvanse is prescribed to children above 6 years.

Cost and Accessibility

Modafinil 200 mg price is $1.37 per pill at Healthnaturo.

The cost of Vyvanse is $15 per pill, as listed by Single Care [16].

User Experiences

Average user rating of 7.3 out of 10.

7.4 out of 10.


Can You Take Modafinil And Vyvanse Together?

Combining Modafinil with Vyvanse may result in mild drug interaction. 

Drug interactions occur when two or more medications are taken together. They can alter the drug's potency and increase the risk of side effects. Individuals taking 200 mg of Modafinil with 10 mg of Vyvanse exhibit a delay in the absorption rate of Modafinil by about 1 hour [17]. 

Additionally, Modafinil and Vyvanse should not be taken with certain other medications to avoid drug interaction. A few of the drugs (not a complete list) interacting with them are mentioned below.

Modafinil Drug Interaction

Modafinil can interact with 497 other medications. Some medicines that should not be taken with Modafinil tablets are Atogepant, Pirtobrutinib, Belzutifan, Ranolazine, Voclosporin, Oxycodone, and Methadone. 

Vyvanse Drug Interaction

Vyvanse can interact with 357 medicines. The medications that should not be co-administered with Vyvanse are Bupropion, Hydroxychloroquine, Norfloxacin, Levoketoconazole, Methadone, Tapentadol, And Ziprasidone. 


Switching From Vyvanse To Modafinil

Factors like health conditions or response to the medication might require switching from Vyvanse to Modafinil. Drug switching can affect the overall cost of care, toxicity level, prevalence of side effects, and effectiveness of the treatment.

However, a switch from Vyvanse to Modafinil must be done under the supervision of a physician. Here are a few facts your doctor might consider when switching the drugs. 

  • Proper medical evaluation- Your doctor might assess your medical condition, health risks, and response to Vyvanse before considering the switch to Modafinil.

  • Tapering off Vyvanse- You might be advised to first taper off Vyvanse by gradually lowering its dosage. Abrupt discontinuation of Vyvanse may cause withdrawal symptoms. 

  • Starting Modafinil dosage- Once you have tapered off Vyvanse, you will be prescribed Modafinil. It is advisable to start with a lower dosage to monitor your response to the medication and further adjust it if needed. 


Warnings And Precautions

While using Modafinil and Vyvanse, it is essential to take a few preventive measures to help minimize the risk of side effects. 

Modafinil Warnings 

  • Modafinil can cause palpitation and thus require frequent monitoring. 

  • It can lower the effectiveness of birth control pills. Thus, it is essential to consult a doctor for an alternative plan. 

  • Modafinil can cause skin allergies, which can cause peeling, blisters, rash, acne, ulcers, or lesions. 

  • This medication can cause drowsiness and dizziness, thus making it unsafe to use heavy machinery and drive. 

  • The use of Modafinil with alcohol is not advisable. 

  • If you are administering a large dose of Modafinil for a prolonged time, it is advisable not to discontinue it abruptly. 

  • It is not advisable to take other brain stimulants or Nootropics with Modafinil dosage. 

  • Before taking Modafinil tablets, make sure you inform your doctor if you are suffering from a kidney and liver disorder, chest pain, a history of drug addiction, or mental illness. 

Vyvanse Warnings

  • Before taking the Vyvanse dosage, ensure you are not allergic to the compounds in its formulation. 

  • Intake of alcohol with Vyvanse is not advisable.

  • Long-term use of Vyvanse can affect the growth of children. 

  • Using heavy machinery or driving is not recommended with Vyvanse, as it can result in drowsiness. 

  • It is not recommended for people who have administered MAO inhibitors in the past 14 days. 

  • To prevent suffering from stroke or sudden heart attack, ensure to inform your doctor if you have a history of high blood pressure and heart disease. 

  • Before taking this medication, inform your physician if you or anyone in your family has mental illness (bipolar disorder, depression, suicidal thoughts, and psychosis), kidney disorder, addiction, and blood circulation disorder. 


Modafinil Vs Vyvanse- Our Final Thoughts 

Below is a summary of everything we have covered in the blog. 





It is very convenient to take
Modafinil dosage (once a day).

A better choice for ADHD. 

It is effective in improving cognition,
food, and chronic fatigue disorder. 

It is recommended for children.

Do not cause overstimulation. 

Available in chewable tablets. 

It is affordable. 

Effective for binge eating disorder.

Lower risk of abuse (Schedule IV drug).

Lower risk of drug interaction. 

Generic version available. 


Faster onset of action. 



It cannot be used in children. 

It is more expensive than Modafinil.

It is not the first choice for treating ADHD. 

Slower onset of action. 

It has a higher risk of experiencing drug interaction. 

Higher risk of abuse (Schedule II drug). 


Generic medication is not available. 


Modafinil and Vyvanse are both FDA-approved prescription drugs with impeccable potency and user benefit. If you are looking for an affordable yet effective treatment option for Excessive daytime sleepiness, better cognition, mood disorder, and fatigue, Modafinil is the choice for you. In contrast, people with ADHD must choose Vyvanse over Modafinil. 


It is important to note that the editorial team's conclusion is based on this blog's findings. Each individual interacts differently with medication; thus, your physician may have a different option from ours. So, we encourage all our readers to consult a doctor before taking either Modafinil or Vyvanse.


Both Modafinil and Vyvanse are brain stimulants, but they affect the functioning of the brain slightly differently.

Vyvanse is more effective for treating ADHD.

For treating excessive daytime sleepiness associated with Narcolepsy, Modafinil is a much better and more effective treatment option.

The cognitive-enhancing ability of Modafinil is much more potent than Vyvanse, thus making Modafinil a better choice for studying.

Vyvanse is a Schedule II drug and thus has a higher risk of abuse if not taken correctly.


  1. Like It or Not, “Smart Drugs” Are Coming to the Office, Harvard Business Review. 

  2. Modafinil | C15H15NO2S | CID 4236 - PubChem.

  3. Vyvanse (lisdexamfetamine dimesylate) C - Accessdata.fda.gov

  4. VyvanseTM (lisdexamfetamine dimesylate), FDA. 

  5. PROVIGIL® (modafinil) Tablets [C-IV], FDA. 

  6. Mechanisms of modafinil: A review of current research, NCBI. 

  7. One in five students have taken the study drug modafinil, the gurdian. 

  8. Trends in On-label and Off-label Modafinil Use in a Nationally Representative Sample, jamanetwork. 

  9. Off-Label Uses of Modafinil, psychiatryonline. 

  10. Modafinil in treatment of fatigue in multiple sclerosis. Results of an open-label study, PubMed. 

  11. Study Results- See clinical study results in adults with ADHD, vyvanse.com.

  12. Modafinil for Attention Deficit Hyperactive Disorder (ADHD), neurotherapeuticscourse. 

  13. A review of the use of modafinil for attention-deficit hyperactivity disorder, tandfonline. 

  14. FDA Committee Rejects ADHD use for Modafinil, npr.org. 

  15. Efficacy, Acceptability, and Tolerability of Lisdexamfetamine, Mixed Amphetamine Salts, Methylphenidate, and Modafinil in the Treatment of Attention-Deficit Hyperactivity Disorder in Adults: A Systematic Review and Meta-analysis, PubMed. 

  16. How much is Vyvanse without insurance? - SingleCare.

  17. Drug Interactions between modafinil and Vyvanse, Drugs.