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Modafinil Drug Test- Does it show up in a drug screen test?

Modafinil Drug Test- Does it show up in a drug screen test?

The significant rise in the Modafinil drug test is due to the increased off-label uses of Modafinil. However, we still struggle to answer the question conclusively:

Does modafinil show on a drug test?

Modafinil drug test is done in several different scenarios and is predominantly done in the corporate world, in athletes, truckers, universities, and people suspected of overdosing or abuse. Being ignorant about it will only land you in trouble. 

This Modafinil guide summarizes how the Modafinil drug test works and the safer way to take the Nootropic. 

 

Modafinil Drug Test- The Basics

Before we try to answer the question, "Will Modafinil show up on a drug test?" let us first get a better idea of the factor that contributes to the Modafinil drug test results. 

If the Modafinil drug test is done after the complete excretion of the product from the body, the test result will show "Negative." So, how do you know if the Modafinil dosage is out of your system? The answer to this question lies in our next question- 

How long does Modafinil stay in the system?

Scientific studies to date explain the metabolism of Modafinil as follows [1,2]-

  • The metabolism of Modafinil produces two metabolites- Modafinil acid and modafinil sulfone. 
  • It is excreted primarily through the urine. 
  • Modafinil acid makes up 35 to 60 percent of the modafinil dose. 
  • The half-life of Modafinil is 15 hours.
  • Modafinil sulfone is produced in insignificant amounts. 

 

Theoretical evaluation of how long does Modafinil stay in your Urine, Hair, and Blood?

The standard dose of Modafinil is 200mg, and let us consider the administration time as hour “zero.” 

With 15 hours of half-life and 65% of Modafinil remaining as an active molecule (130mg), the elimination process will look like [3]-

15th hour- 65mg 

30th hour- 32.5mg

45th hour- 16.25mg

60th hour- 8.125 mg

75th hour- 4.06mg

90th hour- 2.03 mg

105th hour- 1.01 mg 

 

The above computation indicates that Modafinil stays in the system for much longer, even after its cognitive effect declines. It takes approximately four days for the body to eliminate Modafinil.

It is crucial to note the half-life of Modafinil may vary depending on numerous factors. Some of the notable factors determining the half-life of Modafinil include-

  • Genetics
  • The purity and authenticity of the medication
  • Health factors such as renal and hepatic functioning 
  • Bodyweight
  • Interaction with other medications
  • Gender (Clinical studies indicate that females eliminate Modafinil faster than males) [4,5].
  • Age ( older people take longer to eliminate Modafinil than younger people) 
  • Race [6].

Note: The average time for how long Modafinil stays in the system is for a single dose of Modafinil. Users taking the Nootropic every day will take longer to eliminate the compound and its metabolite from the body. 

Modafinil regulations

Modafinil is a schedule IV controlled substance and is not available over the counter. The risk of abuse and dependency is low; however, it is not uncommon. According to Wikipedia, the dependency liability of Modafinil is relatively low, whereas the addiction liability is low to very low [7].  

The legal status of Modafinil:

  • USA- Schedule IV
  • Canada- Rx (prescription drug)
  • UK- prescription only
  • Australia- S4 prescription drug 

Does modafinil show on a drug test ?

 

Does modafinil show on a drug test?

 

80% of Modafinil and its metabolite is excreted through urine [7]. After ingestion of Modafinil, it is available in a testable form for about 30 hours in the urine [8]. It is also detectable in the blood plasma serum. 

Modafinil is not often checked in routine drug screenings. So authority has to conduct specific tests to intentionally look for the presence of Modafinil in the urine and blood. If often common in cases of overdose. 

Your Modafinil drug test report depends on how long ago you took the last Modafinil dosage before the test. Since, Modafininil 200mg takes about four days to excrete from the body, a drug test done on the 5th day or after that will not be able to detect the presence of Modafinil in the system. 

A clinical trial of 20 male volunteers was recorded to take about 72 to 80 hours to eliminate 100mg of Modafinil [9,10]. 

Discontinue your Modafinil intake 80 to 105 hours (3 to 4 days) prior to your drug test to ensure your reports come up negative. 

The chemical structure of Modafinil is different from other stimulants, such as amphetamine; therefore, the chances of a “false positive” report are improbable. 

What kind of Drug tests are done to detect Modafinil 200 mg?

The discussion of the Modafinil drug test cannot be complete without overlooking how it is being detected in the body. The two primary sources of detection are blood and urine. 

Modafinil urine test- 

The detection of Modafinil through urine test is designed to detect Modafinil and its metabolite even several hours after administering the drug. They are also comparatively cheaper than blood tests. 

 

Detection of Modafinil in Blood- 

The modafinil drug test through blood can accurately identify the compound within 2 to 12 hours of administration. The detection of Modafinil through blood is more reliable and accurate. However, it is invasive and far more expensive than a urine test.  

Both samples are screened by GC-MS (gas chromatography-mass spectrometry) or LC-MS (liquid-chromatography-mass spectrometry). The presence of Modafinil can be accurately detectable at a concentration of 2 ng/ml (1 ng = 0.000001 mg) [11]. 

Modafinil brand- Modalert and Provigil drug test 

A drug screening test can detect Provigil and Modalert if they are specialized to detect Modafinil. Normal drug detection tests (5-panel and 12-panel) cannot screen Modafinil and Provigil.

The detection of Modalert and Provigil in the blood and urine is also determined by the administration of the last dosage, age, gender, genetics, and race of the user. People who order Modalert and Provigil without consulting a doctor should cease their administration before a drug test. 

Circumstances for Modafinil drug test

 

Circumstances for Modafinil drug test

 

Modafinil drug test is more prevalent among drug abusers and the four broad categories of organizations listed below. 

Modafinil military drug test-

The cognition-enhancing benefit of Modafinil benefits the military. In the United States, Modafinil 200 mg is approved for use on certain Air force missions. As of 2012, Modafinil is the only stimulant approved for fatigue management. The special operation Forces (SOF) also uses Modafinil during combat battles. 

The United Kingdom's Ministry of Defence and the Indian Air Force use it in their contingency plans. 

 

Corporate World-

The government and private organizations do not commonly test the presence of Modafinil in the system until they have a reason to do so. Employers test for Modafinil and Provigil in the following circumstances. 

  • If the drug is lowering your productivity.
  • If they have a drug abuse policy and your administration of Modafinil is violating it. 

It is often very rare for employers to call for a Modafinil drug test for all new employees. Also, Modafinil is unlikely to reduce your productivity, thus making it less of a concern for the organization. 

 

Athletics- 

Many international sports organizations consider Modafinil a performance-enhancing drug. Therefore, its usage is banned, and a Modafinil drug test is done before an event. Some sporting organizations that have banned the use of Modafinil 200 mg are-

  • The Olympics [12].
  • National Collegiate Athletic Association (NCAA) [13].
  • World Anti-Doping Agency (WADA) governed sporting body.
  • Crossfit [14].
  • Electronic Sports League (ESL) [15].
  • United States Anti-Doping Agency (USADA).

Modafinil can increase alertness, prevent fatigue, and lower reaction time in athletes, which can be advantageous in a competitive match. 

An athlete caught with Modafinil in their system can be suspended for the long term or even be disqualified from the event. They should never buy Modafinil online without a prescription or discontinue its use a week before the drug test is scheduled. 

 

Truckers -

The benefit of Modafinil concerning driving has mixed reviews. The study involving the effects of Modafinil on driving in 16 healthy participants showed that the use of Modafinil dosage reduced lane deviation. It further had a lower effect on off-road tasks and speed deviation. The clinical trial concluded that using Modafinil 200 mg benefits driving performance in drivers with sleep loss [16]. 

Truck drivers in the USA must undergo a 5-panel drug test before obtaining their commercial license. These 5-panel drug tests are not structured to detect the presence of Modafinil in the system. However, it is best to refrain from taking Modafinil dosage before your scheduled drug test. 

The FDA advises refraining from operating heavy machinery and driving after taking Modafinil dosage. 

The driving advisory by the Federal Motor Carrier Safety Administration (FMCSA) and Department of Transportation (DOT) on driving after administering Modafinil includes [17, 18]-

  • The driver is aware of the effects of Provigil or Modafinil in their system.
  • All drivers taking Modafinil should be closely monitored for six months before qualifying. 
  • A document from a physician must be submitted to the medical examiner stating the efficacy of the treatment and that it will not impact your ability to drive a commercial vehicle. 

Will Modafinil show up on a drug test?- User experiences 

Now that we know if Modafinil will get detected in a drug test, let us look at user’s experiences with Modafinil drug test [19]. 

Will Modafinil show up on a drug test

Does modafinil show on a drug test?

Modafinil drug test

Modafinil drug test

Modafinil Drug Test- Our Final Verdict 

Does modafinil show on a drug test?- let’s tackle this question one last time and sum up everything we have learned so far. 

Modafinil drug test will show up POSITIVE if-

  • The drug test is specifically looking for the presence of Modafinil in the system.
  • Taking a Modafinil drug test before the Nootropic has been completely eliminated from the body. 

Discontinuing the administration of Modafinil 200 mg 5 to 7 days before the test will ensure a negative report. 


FAQ's

The primary elimination of Modafinil is through urine, and it takes about 48 to 72 hours for the complete elimination of the Nootropic. Modafinil is detected in the urine without derivatization steps and hydrolysis.

 

Yes, Provigil is detected in the urine screening test. 

 

Modafinil is a controlled substance class IV drug.

The International Narcotics Control Board does not consider Modafinil 200 mg as a psychotropic or narcotic substance.

Yes, Modafinil military drug tests are performed. One may fail the urinary drug test if one takes Modafinil without a prescription.

The half-life of Modafinil in the human body is 12 to 15 hours. Modafinil may last for 22 to 24 hours in the system, depending on its half-life.

Provigil is the brand name of Modafinil, and it is not permissible for truck and commercial vehicle drivers to administer Modafinil until a physician monitors them for six weeks of usage.

The 12-panel drug tests determine the presence of Barbiturates, Tricyclic Antidepressants, Oxycodone, Amphetamine, Cannabinoids (THC), Methamphetamine, Benzodiazepines, Propoxyphene, Cocaine, Phencyclidine, Opiates, and Methadone.


References-

  1. A double-blind, placebo-controlled, ascending-dose evaluation of the pharmacokinetics and tolerability of modafinil tablets in healthy male volunteers, PubMed.
  2. Open-label, single-dose pharmacokinetic study of modafinil tablets: influence of age and gender in normal subjects, PubMed. 
  3. Drug elimination calculator, observablehq.

  4. Open-label, single-dose pharmacokinetic study of modafinil tablets: influence of age and gender in normal subjects, PubMed.
  5. A double-blind, placebo-controlled, ascending-dose evaluation of the pharmacokinetics and tolerability of modafinil tablets in healthy male volunteers, PubMed.
  6. Population pharmacokinetics of modafinil acid and estimation of the metabolic conversion of modafinil into modafinil acid in 5 major ethnic groups of China, Ncbi. 
  7. Modafinil, Wikipedia. 
  8. How Long Does Modafinil Stay In Your System? therecoveryvillage. 
  9. A novel study of screening and confirmation of modafinil, adrafinil, and their metabolite modafinilic acid under EI-GC-MS and ESI-LC-MS-MS ionization, PubMed. 
  10. Detection of modafinil in human urine by gas chromatography-mass spectrometry, PubMed. 
  11. A Critical Review of Properties of Modafinil and Analytical, Bioanalytical Methods for its Determination, tandfonline. 
  12. Modafinil in sports: ethical considerations, Ncbi.
  13. Characteristics of Drug and Dietary Supplement Inquiries by College Athletes, Ncbi.
  14. Drug testing program, crossfit. 
  15. Why are drug tests in eSports only being enforced now?, esports.
  16. Effects of modafinil on simulator driving and self-assessment of driving following sleep deprivation, PubMed. 
  17. Can CMV drivers be qualified while being prescribed Provigil (Modafinil)?. Fmcsa
  18. Medications, dotphysicaldoctor. 
  19. Does modafinil comes up on a drug screen test?, Quora. 
  20. Will modafinil cause me to test positive on a 9-panel drug test?,  justanswer.