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Will Nucynta Show Up On A Drug Test?

Will Nucynta Show Up On A Drug Test?


Nucynta drug tests check for possible misuse or overdose of the pain medication. These tests can detect Nucynta (Tapentadol) in blood for up to 24 hours and 5-6 hours in saliva. In urine, it can be detected for up to 3 to 4 days and in hair for up to 30 days. Detection times may vary based on factors like metabolism, dosage, or how often Nucynta is taken.



Nucynta, a brand of Tapentadol, is an opioid pain medication classified as a Schedule II controlled substance. This indicates that the medication has a high potential for abuse and dependency.

Tapentadol is clinically proven to treat post-surgical pain, migraine, diabetic neuropathy, and other acute and chronic body pain. Despite its prescription use, cases of misuse and recreational use are rising. It is a major concern at the current time and requires effective measures. Thus, people taking this medication often wonder if Nucynta will show up on a drug test.  


Understanding The Need For Tapentadol Drug Tests 

A few key factors indicating the importance of Tapentadol or Nucynta drug screening tests are listed below. 

Monitoring And Preventing Abuse Or Misuse: 

Tapentadol has the potential for abuse, misuse, or addiction. Drug tests help ensure safety and monitor if the patient is taking the prescribed dosage.

Safety Concerns:

Inappropriate use and taking Tapentadol with other substances can cause side effects. Conducting drug tests will help to identify and avoid these risks.

Clinical Supervision:

The tests provide information to healthcare providers regarding patient care. It helps adjust the medication dosage or suggest alternative treatment options.

Regulatory Compliance:

Several organizations require conducting drug tests to ensure compliance with regulations and safety protocols. 

Legal And Liability Considerations:

In cases where Tapentadol use is associated with any accidents or legal proceedings, conducting drug tests can help.


Will Nucynta Show Up On A Drug Test? 

Yes, Nucynta can show up in drug screen tests if performed before its metabolite is eliminated. The detection of Tapentadol in the system is done through Urine, saliva, blood, and hair samples. 

  • Tapentadol and its metabolites can stay in the urine for 3 to 4 days. Nucynta shows on a urine test when a drug screening test is conducted during that period. 

  • It stays about 24 hours in the blood from the last administered dosage. 

  • Tapentadol can be detected in the hair for up to 30 days.

  • In saliva, it can be detected for 5 to 6 hours after administration [1]. 




Tapentadol Urine Drug Screen Test 

Urine is the most preferred drug testing for Tapentadol because it is inexpensive and noninvasive. 

A quantitative Tapentadol Urine drug screen was performed in 2ml of a urine sample. The report recorded the presence of Nucynta metabolites in the urine sample in their generic form as follows [2].  


Nucynta Metabolites or Generic Tapentadol

Urine concentration 


50 ng/mL

Tapentadol glucuronide

100 ng/mL


100 ng/mL


100 ng/mL


Does Nucynta Show Up On A 12-Panel Drug Test? 

Tapentadol can be detected in a 12-panel drug test as this test is done to identify the presence of opioids in the body. 

A 12-panel Urinalysis Drug Screen test can detect the presence of 10 different substances, including propoxyphene, amphetamines, cocaine, benzodiazepines, methaqualone, cannabis, barbiturates, methadone, phencyclidine, and opioids [3]. 


How To Excrete Tapentadol From Body For Urine Test? 

Elimination of Tapentadol takes place in the kidney and is primarily excreted as urine. The first step to accelerate the elimination of Tapentadol is to increase the intake of water and exercising. 

If you are taking prescription Tapentadol brand medications such as Aspadol or Nucynta, it is recommended to be honest with the testing facility about your treatment. 


Tapentadol False-Positive in LC-MS/MS tests 

LC-MS/MS or Liquid Chromatography-Mass Spectrometry/Mass Spectrometry is a technique used to identify and quantify substances like Tapentadol in biological samples. This test might produce a false-positive result for Tapentadol presence.

A study indicated that even when people take up to 600mg of Tapentadol daily, it doesn't cause a false positive result in urine tests [4].


Factors That Affect The Detectability Of Tapentadol 

Key factors that affect how long Tapentadol stays detectable in the body are listed below. 

Dosage And Frequency Of Use-

The dosage and frequency at which Tapentadol is administered affect how long it can be detected. Taking Tapentadol in higher or more frequent doses can result in a larger accumulation of the drug in the body. Additionally, it takes a longer time to eliminate from the system. Thus, it increases the window of detection. 


Metabolism is the body's process of breaking and eliminating a substance. It plays a major role in impacting the detection time of opioid pain medication. People with a faster metabolic rate process eliminate the compound quicker. It results in a shorter detection window. However, in people with slower metabolic activity, the drug can be detected in the body for longer. 

Individual Physiology-

Physiological factors such as organ function, hydration level, and body composition play a key role in determining the detection time of Tapentadol. These factors determine the rate at which Tapentadol is metabolized and eliminated from the body. 


Tapentadol or Nuynta stays in the urine for three to four days.

No, Tapentadol does not affect the amphetamine screen and does not cause a false-positive result.

The use of Tapentadol can cause euphoria that can induce a happy state of mood.


  1. How Long Does Tapentadol Stay in Your System? therecoveryvillage.

  2. Tapentadol and Metabolite, Urine, Quantitative, aruplab.

  3. 12 Panel Drug Screen – Michigan DL Lawyer - Grabel & Associates. 

  4. Can tapentadol cause a false-positive urine drug screen result for amphetamine?, NCBI.