Get 2% OFF at the First BUY (Selected Pills) - Shop Now!

Carisoprodol vs Tramadol - Is Soma Better than Tramadol?

Carisoprodol vs Tramadol - Is Soma Better than Tramadol?

If you're looking for comparative studies between "Carisoprodol vs Tramadol," chances are you're struggling with severe body pain. A National Institute of Health survey estimates about 11 percent of Americans experience body pain every day for three months [1]. It's also one of the leading reasons Americans incorporate complementary health approaches to managing pain.

Soma and Tramadol have been preeminent analgesics paving their way toward improving acute and chronic pain. Their impeccable potency makes it a common ground for users to compare Soma and Tramadol. So, this blog addresses the pharmacological similarities and differences between the two analgesics and helps you choose the proper pain medication. 


Similarities and Differences between Soma and Tramadol

Soma and Tapentadol, both effective analgesics, showcase similarities and differences. This alikeness and dissimilarity can significantly contribute to people choosing between the two pain medications. 





Generic name



Brand name

Soma pill



HAB Pharmaceuticals

Zydus Cadila Healthcare Ltd

FDA approval 

In 1959

In 2008

Legal status

USA (Schedule IV)

USA (Schedule IV)

Australia (Prescription only)

UK (Schedule III)

 Canada (Prescription only) 

Class of drug

Muscle relaxer 

Opioid pain medication 

Structural differences 




The active compound is Tramadol Hydrochloride. The other ingredients include sodium starch glycolate (Type A), Cellulose, silica colloidal anhydrous, magnesium stearate, and microcrystalline. 

The active compound is Carisoprodol. The inactive compounds of the muscle relaxer are stearic acid, croscarmellose sodium, microcrystalline cellulose, starch, hypromellose, povidone, magnesium stearate, and FD&C Red #40, FD&C Yellow #6.


Carisoprodol vs tramadol- Doses and Administration 




The right dosage administration is crucial to keep adverse effects at bay. The Soma pill is available in two dosages 350mg and 500mg. Beginners are advised a lower dose of the muscle relaxer that can be gradually increased depending on the severity of the pain. The maximum dose of the Soma pill is three to four times a day and is not prescribed for long-term use.

The standard dose of Tramadol is 100mg; however, it is best, to begin with a lower dose of 25mg. The maximum dose of Tramadol is 400mg daily and can be administered three to four times based on the pain.

Carisoprodol is available as oral pills, whereas, Tramadol is retailed in the form of capsules, solutions, tablets, and suspensions.

Soma pill and Tramadol intake are not advised for over three continuous weeks. Long-term use of Carisoprodol and Tramadol may increase the user's risk of addiction and dependency. 

Differences between their Uses and Mechanism


Carisoprodol is a centrally acting muscle relaxer prevalent in treating short-term acute pain. When taken in association with rest and physical therapy, it acts against skeletal muscle conditions caused by injury, strain, and sprain. 


The Soma pill working mechanism that helps relieve the pain affects communication between the nerve and the central nervous system. It metabolizes in the liver and is further excreted by the kidneys. 


Patients with a lower level of CYP2C19 (enzyme for metabolization) lead to increased concentration of Carisoprodol in the body. In the liver, the Carisoprodol is metabolized to meprobamate, which significantly accounts for the abuse potential of the Soma pill.


About 25 percent of the Carisoprodol dosage taken is converted to meprobamate, indicating that it is 3.25 times stronger than Carisoprodol. In simpler terms, 200mg of meprobamate is equivalent to 650mg of Carisoprodol [2]. 

Tramadol is a centrally acting analgesic that has opioid agonist properties. In patients with moderate to severe intramuscular, intravenous, and postoperative pain, the use of Tramadol can be effective. The National Health Services identifies Tramadol as a secondary pain medication for treating fibromyalgia. 


It blocks the pain sensation from the body from traveling to the brain receptor, thus inducing a sense of pain relief. 


The Tramadol analgesic undergoes hepatic metabolism to form five different metabolites. 


Of these, desmetramadol is one of the most significant metabolites as it has 200 times the affinity of Tramadol.


Furthermore, the elimination half-life of desmetramadol is 9 hours compared to Tramadol, which is about 6 hours [3]. 


Soma vs tramadol- Efficacy & time of action

For most analgesics, the onset and time of action play a key role in determining their efficacy and potency. For most people, a long onset time can be a deal breaker. Let us all address the fact that none of us would like slow-acting pain medication. 

The onset of action of Carisoprodol is 30 minutes, and the muscle-relaxing and pain-relieving effects last for 5 to 6 hours [4].

On the other hand, the effect of Tramadol begins after an hour of dosing, and it reaches its peak in 2 to 4 hours [5]. 

According to the FDA, the half-life of Carisoprodol is 3 hours, and that of Tramamadol is between 5 to 9 hours. However, the half-life of meprobamate (a metabolite of Carisoprodol) is 6 to 17 hours [4,5]. 

Safety guidelines for Pregnancy and Breastfeeding




Carisoprodol Pregnancy Warnings:

Category: C 

Clinical observations:

Administration of Carisoprodol in pregnant mice at 1, 2.6, and 4.1 times the maximum recommended dose for humans showed postnatal weight gain, reduced fetal growth, and postnatal survival at 2.6 and 4.1 times. Case studies on meprobamate during the first trimester do not increase the risk of significant congenital disabilities [6]. 


Carisoprodol Breastfeeding Warnings:

Excreted into human milk: Yes 

Caution: Monitor infant for signs of sedation.

Clinical observations:

A case report on the use of the Soma pill in nursing mother shows that infant receives an average dose of about 6% of the maternal weight-adjusted dose. The study also indicates that maternal use of the Soma pill may lead to less effective infant feeding due to decreased milk production and sedation [6]. 




Tramadol Pregnancy Warnings:

Tramadol use is not recommended 

AU TGA pregnancy category: C 

US FDA pregnancy category: Not Assigned

Clinical observations:

Tramadol can cross the placental barrier at a concentration ratio of 0.83. Several animal studies indicate that at high doses, Tramadol can affect organ development, mortality rate, and bone growth in the fetus. In addition, prolonged use of opioid analgesics during pregnancy may result in physical dependence in the neonatal, respiratory depression, and neonatal opioid withdrawal syndrome after birth. There are also reports of stillbirths, neonatal seizures, and fetal death [7]. 


Tramadol Breastfeeding Warnings:

Excreted into human milk: Yes  

Caution: Infants should be monitored for respiratory depression and sedation.

Clinical observations:

A study conducted on 75 mothers showed that the amount of Tramadol in breast milk represents a maximum of 2.6% of the proposed dose. Some serious adverse effects in breastfed infants include serious breathing issues, excessive sleepiness, and difficulty breastfeeding [7]. 


Tramadol And Carisoprodol Interactions

Carisoprodol vs Tramadol- the drug interaction of these two analgesics with other treatments and medication is high and may often result in adverse effects. 640 drugs are recognized to interact with Tramadol, categorized as 300 major, 338 moderate, and 3 minor symptoms [8]. 







evening primrose


Benadryl (diphenhydramine)





























Flexeril (cyclobenzaprine)




Tramadol and Food/Alcohol interaction:


The consumption of Alcohol with Tramadol can result in central nervous system depression. It can also cause impairment of judgment and psychomotor skills, and thinking ability. Patients are also advised to avoid activities requiring mental alertness. 


Carisoprodol interaction:

Carisoprodol is accounted to interact with 346 drugs, of which 26 are major, 319 are moderate, and one is minor interaction [9]. 





Norco (acetaminophen / hydrocodone)

Ambien (zolpidem)


Vicodin (acetaminophen / hydrocodone)

Lyrica (pregabalin)


OxyContin (oxycodone)

Xanax (alprazolam)



Benadryl (diphenhydramine)



Lexapro (escitalopram)



Cymbalta (duloxetine)



Tramadol and Food/Alcohol interaction:

The Soma pill interaction with alcohol can cause difficulty concentrating, dizziness, and drowsiness. It can also cause impairment of judgment and thinking. The operation of heavy machinery and driving is not advisable in such conditions [9]. 

Health risks of combining carisoprodol and tramadol


Mixing the Soma pill with Tramadol can cause serious health issues, thus resulting in drowsiness and sedation. In a few cases, such interactions may even be fatal. 

Tramadol and soma high- Which is more prone to abuse? 

“Just because a medicine is prescribed does mean it is safe and cannot cause abuse and addiction.”

Tramadol is a prescription narcotic, and ever since it has been recognized as a prescription analgesic, it has been criticized as a “risky” choice. The use of the analgesic can be very addictive and lead to death associated with overdosing.

According to a study by the National Survey of Drug Use and Health, about 1.8 million Americans have abused Tramadol alone or in combination with other compounds over the past three years [10]. 




Tramadol can cause a high that elevates the mood, makes people feel relaxed, reduces anxiety, and dulls the pain. Like most prescription drugs, if taken as advised by the doctor, the risk of addiction and abuse is significantly reduced. 

The US Drug Intelligence Center classifies Carisoprodol as one of the biggest threats for abuse among muscle relaxers [11]. People with a history of substance abuse disorder use Carisoprodol in several ways. At higher doses, Carisoprodol can cause a euphoric high. Its sedation may include elevated mood, hallucinations, increased energy, and socialization. 

Soma abuse also causes drowsiness, loss of coordination, slower reaction time, and confusion. 

Soma vs tramadol- Assessments of Side effects 




With the advancement of online pharmacies, there is an acceleration in users who buy Soma and Tramadol online. Such non-prescription users are often more vulnerable to experiencing side effects due to their lack of product information.  

The side effects of Tramadol commonly noted in users include slow breathing, dilated pupil, faster heartbeat, chills, teary eyes, stomach cramps, runny nose, and increased blood pressure. At the same time, the adverse effects of the Soma pill are drowsiness, dizziness, headache, irritability, nervousness, tremor, insomnia, and agitation. 

Apart from the side effects listed here, there are other possible adverse effects of the analgesics. Each individual reacts differently to the analgesic, thus portraying different severity and effects. 

Which among Soma and Tramadol is affordable? 

None of us would like a burn a hole in our pocket to buy pain medication. Most of us are constantly surfing the internet to find affordable options. So, which among Soma and Tramadol is an affordable choice of analgesic? 

The cost of Soma 500mg and Soma 350mg at healthnaturo is $ 1.34 per pill. In comparison, the price of Tramadol is $3.5 per pill [12].  

User review of Carisoprodol and Tramadol

Testimonials and reviews of Soma and Tramadol are an outline of their benefits and user experience. The user review for Tramadol on the website Drugs has an average rating of 6.8 out of 10 from 1730 ratings. 61% of the people reported having a positive experience, whereas 25% claimed to suffer adverse effects. 


Carisoprodol review from Drugs indicates an average rating of 9.1 out of 10 for muscle spasms from a total of 247 ratings. 90% of all people noted experiencing a positive effect, and 5% suffered from a negative experience.  


Carisoprodol vs tramadol- Our final thought 

In this comparative study between Carisoprodol vs Tramadol, the Soma pill emerges as a better option for people struggling with short-term acute pain. It is cheaper than Ultram and showcases lower potency for abuse and addiction. However, Tramadol is a better choice of analgesic for users looking for chronic pain management. 

Tramadol also has a higher risk factor for drug interaction and causes severe side effects in users compared to the Soma pill. So, people undergoing other treatments are more likely to be prescribed Carisoprodol. 

The higher efficacy and faster onset of action of the Soma pill compared to Tramadol is a major contributor to its popularity. However, Tramadol is available in numerous forms; Carisoprodol is only available as oral tablets. 


No, the administration of Carisoprodol with Tramadol is not advisable. Such interactions can cause severe health issues in the user.

Tramadol has a wider analgesic action spectrum and is beneficial in treating acute and chronic pain. Whereas the Soma pill is effective in helping manage short-term acute pain. However, the onset of action of Carisoprodol is faster compared to Tramadol.

No, Tramadol is not a muscle relaxer but a synthetic opioid analgesic.


  1. NIH analysis shows Americans are in pain, National Institute of Health.

  2. Carisoprodol, Wikipedia

  3. Tramadol, Wikipedia

  4. How Long Does Soma (Carisoprodol) Stay in Your System?, Verywell Mind

  5. How Long Does Tramadol Stay in Your System?, Verywell Mind

  6. Carisoprodol Pregnancy and Breastfeeding Warnings, drugs

  7. Tramadol Pregnancy and Breastfeeding Warnings, drugs

  8. Tramadol interactions, Drugs

  9. Carisoprodol Interactions, Drugs. 

  10. Misuse of Tramadol in the United States: An Analysis of the National Survey of Drug Use and Health 2002-2017, NCBI. 

  11. Soma addiction - it's a real thing, havenhelps. 

  12. rochesterpainclinic