Tadalafil Tablets
What Is Tadalafil Tablet?
Tadalafil is a prescription medication that belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors. It is used to manage certain men’s health conditions, such as erectile dysfunction. Tadalafil ED medications work by improving blood flow in the body and are known for their long-lasting effects.
History Of Tadalafil
Tadalafil was first researched in the 1990s by the ICOS Corporation, a U.S.-based biotechnology firm. In 1998, ICOS partnered with pharmaceutical giant Eli Lilly to co-develop and market the drug. This collaboration led to promising clinical trial results in 2002, revealing that Tadalafil could remain effective for up to 36 hours. This was significantly longer than similar medications available at the time.
Following these findings, the U.S. Food and Drug Administration (FDA) approved Tadalafil in 2003 for the treatment of erectile dysfunction under the brand name Cialis.
Eli Lilly acquired ICOS in 2007, gaining full ownership of the drug and its branding. In 2009, it received FDA approval for treating pulmonary arterial hypertension. In 2011, it was approved for managing benign prostatic hyperplasia (BPH).
By 2018, generic versions of Cialis became available, making Tadalafil more accessible and affordable for patients worldwide [1].
Tadalafil Tablet Uses
Tadalafil is prescribed for various health conditions such as-
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Erectile Dysfunction (ED)- Helps achieve and maintain an erection in men during sexual activity.
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Benign Prostatic Hyperplasia (BPH)- Relieves urinary symptoms such as frequent urination, weak stream, and difficulty in starting urination.
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Pulmonary Arterial Hypertension (PAH)- Improves the ability to exercise by relaxing blood vessels in the lungs and reducing blood pressure in the pulmonary arteries [2].
How Tadalafil Works?
Tadalafil works by blocking an enzyme called phosphodiesterase type 5 (PDE5), which is found in areas like the penis, lungs, and prostate. This enzyme normally breaks down a molecule called cGMP, which helps relax muscles and improve blood flow.
By preventing the breakdown of cGMP, Tadalafil allows it to work longer, leading to better blood flow during sexual stimulation. It helps signs of PAH by lowering pressure in the lungs and relaxing muscles in the prostate and bladder (for BPH) [3].
Tadalafil Benefits
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Offers long-lasting effectiveness lasting up to 36 hours.
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Available in a variety of dosage strengths for flexible use.
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It may help improve overall confidence and quality of life.
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Taken just once a day, no need for multiple doses.
Tadalafil Brand Name
Tadalafil is marketed under a few well-known brand names, with Cialis being the most recognized for treating erectile dysfunction, and Adcirca for pulmonary arterial hypertension [4].
The price of Cialis may be higher due to branding, research and development costs, and marketing. For people looking for more affordable options, Vidalista and Tadalista are widely used alternatives that offer similar effectiveness at a lower cost.
Tadalafil Dose And Timing
Tadalafil is available in various strengths, and the dose depends on the condition. It can be taken in two main ways-
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As needed- The best time to take Tadalafil for ED is at least 30 minutes before sexual activity.
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Once daily- Taken at the same time each day, regardless of sexual activity. This option is often used for daily ED management or other approved conditions like BPH [5].
How To Take Tadalafil Tablets?
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Swallow the tablet whole with a glass of water.
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Do not crush, split, or chew it.
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The Tadalafil dosage for erectile dysfunction can be taken with or without food.
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Avoid taking more than one dose in a 24-hour period.
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For daily use, take the tablet at the same time each day.
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For as-needed use, take it at least 30 minutes before sexual activity.
Who Can Take Tadalafil Tablets?
It may be suitable for you if-
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You are 18 years or older.
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You have been diagnosed with a condition that tadalafil treats.
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You are not taking medications that interact with PDE5 inhibitors.
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You do not have a heart, liver, or kidney disorder.
Who Should Avoid Tadalafil?
Tadalafil may not be suitable for everyone. Always consult a healthcare provider before use, especially if you-
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Have had an allergic reaction to Tadalafil or any similar medication.
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Are taking nitrates for chest pain (angina).
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Recently had a heart attack or stroke.
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Have low blood pressure or uncontrolled high blood pressure.
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Have experienced vision loss due to reduced blood flow to the eye.
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Have blood-related conditions like sickle cell anaemia, leukaemia, or multiple myeloma.
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Have Peyronie’s disease or any other structural issue with the penis [6].
Tadalafil Side Effects
The common side effects of Tadalafil include:
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Headache
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Flushing (warmth or redness of the face).
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Nausea or upset stomach.
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Stuffy nose
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Muscle pain or back pain.
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Pain in the arms or legs.
Stop using this medication and contact your doctor immediately if you experience the following Tadalafil tablet side effects-
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Light-headedness.
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A painful or prolonged erection lasting more than 4 hours.
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Sudden vision changes or loss of vision.
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Ringing in the ears or sudden hearing loss.
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chest pain.
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Signs of an allergic reaction: hives, difficulty breathing, swelling of the face, lips, tongue, or throat [7].
Tadalafil Warnings And Precautions
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Inform your doctor if you have heart, liver, kidney, or eye conditions.
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Excessive drinking can increase the risk of side effects like dizziness and low blood pressure.
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Avoid grapefruit or grapefruit juice, as it may affect how tadalafil works in your body.
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Tadalafil is not suitable for women or individuals under 18.
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Never take more than the prescribed dose or combine with other ED medications.
Tadalafil Interactions
Before using Tadalafil, inform your doctor about all medications you take. Certain drugs may interact with Tadalafil, increasing the risk of side effects or reducing its effectiveness.
|
Drug Class |
Examples |
Interaction Result |
|
Guanylate cyclase stimulators |
Vericiguat (Verquvo), Riociguat (Adempas) |
May dangerously lower blood pressure |
|
Nitrates |
Nitroglycerin (Nitrostat), Isosorbide dinitrate (Isordil), Mononitrate |
Risk of severe drop in blood pressure |
|
Alpha-blockers |
Tamsulosin (Flomax), Terazosin, Alfuzosin (Uroxatral) |
Can cause excessive blood pressure drop. |
|
Blood pressure medications |
Losartan, Enalapril, Amlodipine, Metoprolol |
May enhance blood pressure-lowering effects |
|
Other PDE5 inhibitors |
Sildenafil, Vardenafil, Avanafil, Adcirca (tadalafil for PAH) |
Increases side effect risk, especially low blood pressure |
|
Protease inhibitors |
Ritonavir, Atazanavir, Darunavir |
May increase tadalafil levels, raising risk of side effects |
|
Antifungal drugs |
Itraconazole, Ketoconazole, Voriconazole, Levoketoconazole |
Can raise tadalafil concentration in the blood |
|
Antibiotics |
Clarithromycin, Erythromycin, Rifampin |
May raise side effect risk or lower tadalafil effect. |
|
Antiseizure medications |
Carbamazepine, Phenytoin, Phenobarbital |
May lower tadalafil levels, reducing effectiveness [8] |
Tadalafil Tablets Options Available At Healthnaturo
At Healthnaturo, we offer a variety of Tadalafil tablet options to meet different treatment needs. These include Tadalista Super Active 20 mg, a softgel capsule designed for faster absorption. The Vidalista Professional is a sublingual tablet that works quickly when placed under the tongue. For standard dosing, Vidalista 20 mg is ideal for those with mild to moderate erectile dysfunction, while Vidalista 40 mg and Vidalista 60 mg provide higher strengths for individuals needing stronger support. All these options are available with discreet delivery and come from trusted, reputable manufacturers.
Tadalafil Alternatives At Healthnaturo
Healthnaturo offers effective alternatives such as Sildenafil and Vardenafil. These medications belong to the same class of PDE5 inhibitors and are commonly used to treat erectile dysfunction. While Sildenafil is known for its fast-acting results, Vardenafil is often preferred for its reliability and fewer food interactions. Both options are available in various strengths to suit different needs.
References
- Tadalafil, Wikipedia.
- Tadalafil, medlineplus.
- Tadalafil, NCBI.
- Tadalafil, nhs.uk.
- Tadalafil Dosage, Drugs.
- Who can and cannot take tadalafil, nhs.uk.
- Tadalafil, Drugs.
- Cialis interactions: Alcohol, medications, and other factors, medicalnewstoday.
FAQ's
No, tadalafil is not classified as a controlled substance.
No, 10 mg is typically used as needed; the daily dose is usually 2.5 mg or 5 mg. Consult your doctor for guidance.
Tadalafil is generally safe when used as prescribed, but it may not be suitable for everyone, especially those with heart or liver conditions.
Yes, tadalafil can cause a mild drop in blood pressure due to its vasodilating effects.
The maximum dose of Tadalafil for erectile dysfunction is 60 mg per day for as-needed use, or 5 mg daily for ongoing use, depending on the condition.
Yes, a low-dose version (2.5 mg or 5 mg) is available for daily use to maintain readiness for sexual activity.
No, it is not advisable to cut Tadalafil 20mg in half.
No, Cialis (tadalafil) is not a blood thinner.
Tadalafil does not typically increase heart rate but can cause cardiovascular effects in sensitive individuals.
Tadalafil is not FDA-approved for use in women and should only be taken under medical advice in off-label situations.
Tadalafil may help some men last longer by improving erectile function, but it is not designed specifically for delaying ejaculation.
Yes, it enhances erectile response by improving blood flow, helping men achieve and maintain a firmer erection with sexual stimulation.
The recommended dose for BPH is 5 mg once daily; exceeding this is not advised within 24 hours.
Tadalafil is not approved for high blood pressure, but it is used for pulmonary arterial hypertension at 40 mg daily under medical supervision.
Tadalafil 20 mg is not approved or recommended for use in females.
Yes, Tadalafil 40mg is advised for managing the signs of ED.
The generic name for Cialis is Tadalafil.
The Long-term side effects of Tadalafil (especially with daily use) may include muscle pain, indigestion, headaches, nasal congestion, priapism, and lower blood pressure.