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Sildenafil Citrate Tablets

What Is Sildenafil Citrate?

Sildenafil Citrate is a prescription medication commonly used to treat erectile dysfunction (ED) in men. Initially developed for managing high blood pressure in the lungs (pulmonary arterial hypertension), Sildenafil gained wider use after its benefits in treating ED became clinically recognized. It is now one of the most studied and widely used treatments for this condition.

Sildenafil is available in various dosages and formulations, including several generic versions. These generics contain the same active ingredient and offer a cost-effective alternative to the original branded version.

History of Sildenafil

Sildenafil's development began in the late 1980s when researchers at Pfizer were investigating potential treatments for heart-related chest pain (angina). During clinical evaluations, the compound showed a unique side effect, improved erectile function, which redirected its development focus.

By 1991, clinical trials were underway to assess its effectiveness in treating erectile dysfunction. Recognizing its potential, Pfizer secured a patent for the use of Sildenafil in ED treatment in 1994.

The drug received FDA approval in the United States on March 27, 1998, and was launched under the brand name Viagra, becoming the first oral ED medication available on prescription.

The expiration of Pfizer’s patent in 2012 opened the market to generic alternatives. In June 2013, Teva Pharmaceuticals launched the first FDA-approved generic version of Viagra in the U.S., significantly reducing costs and increasing accessibility.

Sildenafil Tablet Uses

The primary Sildenafil uses include treating erectile dysfunction, a condition in which a man has difficulty achieving or maintaining an erection. In some cases, Sildenafil is also prescribed for the treatment of pulmonary arterial hypertension (PAH) [1]. It is a type of high blood pressure that affects the arteries in the lungs and the heart [2].

How Sildenafil Citrate Works?

Sildenafil Citrate works by improving blood flow to the abdomen. It belongs to a group of medications called phosphodiesterase type 5 (PDE5) inhibitors. These medications help relax the smooth muscles in the blood vessel walls [3]. By blocking the PDE5 enzyme, it prevents the breakdown of a substance called cyclic GMP (cGMP), which is responsible for relaxing muscles and widening blood vessels. This action allows more blood to enter the penis, making it easier to achieve and maintain an erection [3].

Benefits Of Sildenafil Citrate Tablets

Some of the key benefits of using Sildenafil Citrate include-

  • Enhances sexual confidence and performance.

  • Available in various strengths to suit individual needs.

  • Starts working within 30 minutes.

  • The action of Sildenafil tablets lasts for about 4 to 6 hours.

  • Offers a non-invasive oral treatment option for ED.

Sildenafil Brand Name

Sildenafil Citrate is available under several brand names, both as original and generic versions. The most well-known brand is Viagra, developed by Pfizer [4]. In addition to Viagra, there are many generic versions that contain the same active ingredient and offer similar effectiveness.

Some of the other common Sildenafil options include-

Sildenafil Options

Manufacturer

Malegra

Sunrise Remedies

Aurogra

Aurochem Laboratories

Cenforce

Centurion Laboratories

Fildena

Fortune Healthcare

Kamagra

Ajanta Pharma Ltd

Revatio

Pfizer

Eriacta

Ranbaxy Laboratories

These medications contain Sildenafil as the active compound but may vary by manufacturer, dosage, and appearance.

Sildenafil Dosage Guide

Sildenafil is available in the dosage options of 25mg, 50mg, and 100mg [5]. Some alternatives, such as Malegra 200 mg, offer higher doses for those with more severe symptoms. It is ideal for individuals who do not respond well to lower doses.

The sildenafil dose for erectile dysfunction should begin with lower strengths, which can be increased gradually after consulting a doctor.

For pulmonary arterial hypertension (PAH), Sildenafil is marketed under the brand name Revatio. The FDA-approved dosage for Revatio is 20 mg. An injectable form of Revatio is also available and is mainly used in hospitals [6].

How To Take Sildenafil Tablets?

The directions for taking Viagra (Sildenafil) are listed below-

  • Swallow the Sildenafil medication with water.

  • It can be taken with or without food, but a high-fat meal may delay its effect [7].

  • Avoid grapefruit juice, as it may interfere with effectiveness [8].

  • Sexual stimulation is required for the medication to work [9].

  • Swallow the tablet whole; do not crush, chew, or break it.

  • Revatio is taken three times a day with a dose gap of four to six hours.

  • ED treatment options such as Viagra, Malegra, Aurogra, and Cenforce should be taken once in 24 hours, 30 to 60 minutes before intercourse.

When To Take Sildenafil?

The best time to take the Sildenafil dose is 30 to 60 minutes before sexual activity. And do not take more than one dose in 24 hours, as this can increase the risk of side effects.

Who Can Take Sildenafil Citrate?

Most men above the age of 18 years can take Sildenafil tablets IP for managing symptoms of erectile dysfunction. In addition, the use of Sildenafil for PAH is recommended for adults and children (but under strict medical supervision) [10].

Sildenafil Prescription Requirement

In most countries, Sildenafil Citrate requires a valid prescription from a licensed healthcare provider. A doctor helps determine the appropriate dosage, assess potential risks, and ensure the safe use of the medication.

People must visit a doctor, as ED may be a sign of another health problem, such as -

  • Heart disease

  • Diabetes

  • Parkinson’s disease

  • High cholesterol

  • High blood pressure [11].

Your doctor may look for the following things that can affect the risk of ED, such as-

  • Testing the level of testosterone in the early morning.

  • Reviewing the prescription medications.

  • Checking daily habits such as smoking and drinking [11].

Who Should Avoid Sildenafil?

Some people who should not use Sildenafil tablets without consulting a doctor are-

  • People with an allergic reaction to Sildenafil.

  • People with the following health conditions-

    • Liver problem

    • Serious heart disorder.

    • Having low or high blood pressure.

    • Having a rare inherited eye disease, such as retinitis pigmentosa.

    • People with sickle cell anaemia.

    • Stomach ulcers

    • Bleeding problem.

    • Cancer.

  • If you take medicine containing nitrates.

  • People who have had a stroke or a heart attack [10].

Sildenafil Side Effects

The most common side effects of Sildenafil include-

  • Headache

  • Dizziness

  • Diarrhea

  • Flushing

  • Nasal congestion

  • Upset stomach

  • Nausea

  • Rash

  • Pain in your muscles, back, arms, or legs [12]

The severe side effects of Sildenafil, which require immediate medical attention, are listed below-

  • Trouble swallowing

  • Swelling of the face, lips, mouth, tongue, or throat

  • Breathing problems

  • Hives

  • Faster heart rate

  • Stomach cramps

  • Painful and prolonged erection [12].

Precautions And Warnings

  • Avoid the use of Sildenafil tablets if you have been advised to avoid sexual activity due to heart-related conditions.

  • Avoid alcohol while using Sildenafil, as it can reduce effectiveness and increase side effects.

  • The medication is not intended for children.

  • Do not combine Sildenafil with other ED medications, such as Vardenafil and Tadalafil.

  • The use of Revatio by women should only be done if advised by a doctor.

  • Sildenafil tablets do not protect against sexually transmitted diseases.

Sildenafil Interactions

Sildenafil Citrate may interact with certain medications and supplements that can increase the risk of side effects or reduce its effectiveness.

Some common drug interactions of Sildenafil include-

Medication group

Example

Interaction

Nitrates

Nitroglycerin (Nitrostat), Isosorbide dinitrate (Isordil).

Risk of dangerously low blood pressure.

GC Stimulators

Riociguat (Adempas), Vericiguat (Verquvo).

May cause severe blood pressure drop.

Alpha-blockers

Prazosin (Minipress), Doxazosin (Cardura), Terazosin.

Can cause dizziness and fainting due to low blood pressure.

Blood Pressure Medications

Amlodipine (Norvasc), Lisinopril (Zestril), Valsartan (Diovan), HCTZ.

Enhanced blood pressure-lowering effect.

ED Medications

Tadalafil (Cialis), Vardenafil (Levitra), Avanafil (Stendra).

Risk of overdose, priapism, and other serious side effects.

Antibiotics

Erythromycin

May raise Sildenafil levels and side effects.

Antifungal drugs

ketoconazole, itraconazole.

It can increase the effect of Viagra and the risk of side effects.

PAH Medications

Adcirca.

Combining can result in excessive dosing of PDE5 inhibitors.

Herbal Supplements

St. John’s Wort

It may reduce the effectiveness of Sildenafil [13].

Is Sildenafil The Same As Viagra?

Sildenafil is the active ingredient used in the brand drug Viagra. Both contain the same compound and work in the same way to treat erectile dysfunction.

The key difference lies in the branding and pricing-

  • Viagra is the original brand developed and marketed by Pfizer.

  • Sildenafil tablets are available as generic versions, often produced by other pharmaceutical companies after the original patent expired.

While the effectiveness, safety, and mechanism of action are the same, generic Sildenafil is typically more affordable than the brand-name version.

Sildenafil Tablets Options Available At Healthnaturo

At Healthnaturo, we offer a wide range of Sildenafil tablet options to cater to varying needs and preferences for erectile dysfunction treatment.

Among our available options is Malegra 200 mg, a high-strength Sildenafil tablet designed for men who require a stronger solution for improved performance. It is a popular choice among those who do not achieve desired results with lower doses.

We also provide Aurogra 100 mg, a reliable and commonly used variant of sildenafil. Known for its consistency and effectiveness, it is suitable for most men starting their ED treatment journey.

The Cenforce range at Healthnaturo includes multiple strengths to suit individual tolerance and medical needs. You can choose from Cenforce 100 mg, Cenforce 150 mg, or Cenforce 200 mg, depending on the severity of the condition.

For people seeking an alternative dosage form, Cenforce Professional 100mg tablet is also available. This sublingual tablet dissolves quickly under the tongue, offering a rapid onset of action.

Sildenafil Alternatives at Healthnaturo

The Sildenafil alternatives at Healthnaturo include Tadalafil and Vardenafil. Any change in the medication should be made after consulting a doctor.

References

  1. Sildenafil Tablets for Pulmonary Hypertension - Cleveland Clinic.
  2. Pulmonary hypertension - Symptoms and causes, MayoClinic.
  3. Sildenafil, DrugBank.
  4. Sildenafil - Wikipedia.
  5. Viagra (Sildenafil) Dosages for Erectile Dysfunction: GoodRx.
  6. Sildenafil (Revatio), phassociation.
  7. Sildenafil: MedlinePlus Drug Information.
  8. Effects of grapefruit juice on the pharmacokinetics of sildenafil, PubMed.
  9. Review Sildenafil (Viagra) and Ophthalmology, sciencedirect.
  10. Who can and cannot take sildenafil, nhs.uk.
  11. Where and How Do You Get a Prescription for Viagra?, goodrx.
  12. Sildenafil (Viagra, Revatio) - Uses, Side Effects, and More, webmd.
  13. Viagra Interactions: Alcohol, Medications, and Others, healthline.

FAQ's

Take the lowest effective dose, avoid alcohol, and do not mix with interacting medications like nitrates.

Only once in a 24-hour period, unless otherwise directed by your doctor.

100 to 200 mg is the recommended maximum dose within 24 hours.

Yes, in many countries, a prescription is required to buy Sildenafil.

Yes, if prescribed by a doctor, one can take a Sildenafil 200mg dosage.

More than 200 mg per day may increase the risk of serious side effects and should be avoided.

It is used to treat erectile dysfunction and offers an easier-to-consume alternative for those who dislike pills.

The Viagra generic name is Sildenafil.

Some low doses may be used daily under medical guidance, especially for certain conditions like PAH.

Yes, when taken under the supervision of a doctor, it is okay and safe to take Sildenafil 100mg.

It takes about 30 minutes for sildenafil ED medication to start working.

Take it on an empty stomach about 30 to 60 minutes before sexual activity. Also, avoid taking heavy meals and alcohol.

It enhances blood flow to specific areas by inhibiting the PDE5 enzyme and improving blood circulation in the body.

Primarily for erectile dysfunction (ED) and also for pulmonary arterial hypertension (PAH).

The use of Sildenafil is considered safe when used after consulting a doctor. However, it may not be suitable for everyone, especially those with certain heart, liver, and kidney disorders.