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Modalert 200mg: Mechanism of action and clinical application

Modalert 200mg: Mechanism of action and clinical application

Modalert is a wake-promoting compound with similar clinical properties to conventional brain stimulants. Over the years, the non-prescription use of Modalert by Sun Pharma has observed a potential rise. We believe that inadequate knowledge plays a crucial role in causing side effects from the Nootropic. Thus, the need to have a piece of detailed product information, including its working mechanism, is essential. This blog, therefore, takes cognizance into informing our readers of the basic details of the Nootropic for enhanced performance.

 

Composition: What is the chemical in Modalert?

Active Ingredient: The active ingredient of Modalert is Modafinil.

Inactive Ingredients: The inactive ingredient of Modalert by Sun Pharma is Croscarmellose sodium, lactose monohydrate, pregelatinized starch, microcrystalline cellulose, magnesium stearate, and povidone [1].

What is Modalert used for?

The FDA approves using Modalert 200mg as a prescription drug for hypersomnia. The use of the Nootropic is advisable for almost all people, irrespective of their gender and age. In addition to its prescription use, the widespread off-label benefits of the Nootropic are- 

 

Off-label indications-

  • Enhancement of cognitive ability

  • Boosting energy

  • As a second line of treatment for mental health issues.

  • By students for better grades.

 

Investigational indication

  • Depressive Disorder

  • Schizophrenia

  • Major ADHD

  • Bipolar Depression

  • Chronic Fatigue Syndrome

Study of the Neurochemical Actions and Effects of Modalert on Cognition

A double-blind placebo-controlled study on healthy adults taking a three-day course of Modafinil (Modalert 200 mg and 400 mg) was done. The efficacy of both the strengths of Modafinil was identical. An MRI study after a single dose of Modafinil 200mg after overnight sleep deprivation found the use of the Nootropic to improve the user's working memory and associated cortical activation. The effect of Modalert on cognition in the psychiatric population is studied, including a study on 20 patients with Chronic Schizophrenia. This study exhibits Modafinil 200mg to cause significant improvements in performance.

The neurochemical action of Modalert on cognition possesses multiple effects on the stress response systems in the brain. Elevation of extracellular glutamate Serotonin and activating the orexinergic system includes decreasing GABA. In clinical studies, the use of Modalert shows efficacy in numerous psychiatric and neurological disorders.

The working mechanism of Modalert

It is scientifically proven that Modafinil works by targeting the hypothalamus region of the brain. The Nootropic works by inhibiting the dopamine reuptake. A low level of dopamine hormone in the human brain is associated with causing several mental health issues. It further accelerates the release of orexin, which plays a key role in regulating wakefulness in users.

 

Working-mechanism-of-Modalert

 

Impact of Modalert on hormones

↑ NOREPINEPHRINE

↓ GABA

↑ DOPAMINE

↑ HISTAMINE

Helps in increasing and improving cognitive arousal

Increases neuronal excitability

It plays a crucial role in improving the brain's executive functions and enhancing motor control.

Modalert promotes Wakefulness in users by elevating the secretion of histamine.

 

 

 

 

↑ GLUTAMATE

↑ OREXIN

↑ ACETYLCHOLINE

↑ SEROTONIN

It has a vital role in the brain’s fundamental functions, which are essential for memory and learning.

Wakefulness-promoting peptide

Stimulates Learning and Memory

It enhances the person's mood.

 

Pharmacokinetics: An illustration of Modalert activity

mechanism-of-action

Image ref- Psychscenehub [4]

 

The fraction of the Modalert dose that reaches the systemic circulation in the body is 80%. The onset of the action of the Nootropic is 30 minutes, and the Cmax (peak level) reaches within 2 to 3 hours of intake of the dosage. The intake of food may slow down the process of absorption. Scientific studies on Modalert usage indicate that 60% of the Nootropic is bound to the plasma protein.

The Modalert 200mg has two primary circulating metabolites: Modafinil sulfone and Modafinil acid. These metabolites are inactive and play no additional role in the wakefulness-promoting action of the medication. However, Modafinil sulfone has anticonvulsant effects that are effective in helping with epileptic seizures.

The elimination of this Nootropic begins in the liver, and the kidney carries it out. The process aids assistance with cytochrome-mediated oxidation. The elimination half-life is approximately 10 to 12 hours, indicating that it takes 24 hours for the body to remove the Modafinil compound. 80% of the excretion of the Nootropic takes place through the urine. The excretion process of the Nootropic Modalert by Sun Pharma slows down in the elderly and patients with renal impairment and hepatic issues.

Identification of Modalert 200mg Nootropic

The advancement of online pharmacies has brought convenience for customers and the possibility of being swindled. Thus, an identification test demonstrating its authenticity is crucial to ensure that the medication you received is genuine.

 

identification-of-modalert

 

Steps to identity your medication’s authenticity

 

The appearance of the tablet:

Modalert tablets are white to off-white. They are capsule-shaped uncoated tablets with “41” debossed on one side and “J” on the other side [6].   

 

Manufacturer:  

One of the leading manufacturers of Modalert 200mg is Sun pharmaceuticals. Besides Sun pharma, several other pharmaceutical giants are manufacturing Modalert, such as Steris Healthcare and INTAS.

 

Other identification factors-

  • Check for damaged pills or empty blister slots.

  • Examine the manufacturing date and the expiry date of the product.

  • It is essential to scan whether the pill is a sealed pack; if not, some pills might be missing.

Healthnaturo provides a 100% refund or shipping of the damaged product within 24 hours of confirmation. In case of damage, send a clear picture of the medication and the package. We, however, ensure the quality of our products and services. The Modalert online price on our website is about $1.6. Inclusive to these, Healthnaturo also provides 24x7 customer support, free shipping, and refilling reminders to all customers.


FAQ's

Several Modalert reviews specify the taste of the Nootropic as sweet and sour. A user review indicates strong notes of sweetness and sourness [2].  Another Reddit user says that the Modalert 200mg has a caffeine-like taste, including a sweet and sour taste [3]. However, there were no reports of bitterness

Modafinil, along with its brand version Modalert, is a novel stimulant. They have significant features that distinguish the Nootropic from other brain stimulants.

For a standard dose of Modalert 200 mg, the half-life can last up to 15 hours [5].

On reaching the body, it works on the human brain localizing the hypothalamus region to reduce extreme sleepiness from Obstructive sleep apnea and Narcolepsy. It helps to restore the disrupted natural sleep cycle in the users. Its effect on the brain encourages several off-prescription uses, including induction of better cognitive ability, enhancement of the mood, and lost energy in the user


References-

  1. Medication guide, FDA 

  2. Two Years and Zero Regrets Modafinil (Modalert), Erowid. 

  3. Nootropic, Reddit

  4. Modafinil and Armodafinil- Mechanism of action, psychscenehub

  5. How Long Does Modafinil Stay In Your System?, Banyantreatmentcenter

  6. Modafinil 100mg tablets, medicines.org