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Tapentadol 100mg

Buy Tapentadol 100mg Online

Introduction: What is Tapentadol 100mg and How Does it Work?

Tapentadol is a novel, centrally-acting opioid analgesic with a dual mechanism of action, making it useful for acute, chronic, and neuropathic pain. It was first synthesized in the USA and marketed by Ortho-McNeil-Janssen Pharmaceuticals.

The Tapentadol Hydrochloride Tablets were approved by the FDA (Food and Drug Administration) on 24th December 2008. It is suggested to be the first agent of a new drug class (MOR-NRI). And its multimodal functioning reduces the risk of drug interaction and side effects.

Mechanism Of The Tapentadol 100mg Pill

Tapentadol has 30 minutes of onset of action, and its analgesic effects last for 4 to 6 hours. The analgesic effect of Tapentadol Hydrochloride Tablets is based on two mechanisms of action- MOR (mu-opioid receptor) agonism and Noradrenaline reuptake inhibition (NRI).

Tapentadol binds to the MOR selectively and is 44-fold lower than Morphine.

The NRI increases the noradrenaline (NA) level in the body, which regulates the analgesic effect of Tapentadol through the activation of the inhibitory alpha-2 receptors.

These Alpha-2-adrenoceptor are clinically proven compounds that induce analgesic effects and help in the treatment of acute and chronic body pain.

The dual mechanism of action of Tapentadol also contributes to its opioid-sparing effects.

The Metabolism and Elimination of Tapentadol 100 mg

97% of the administered Tapentadol dosage is extensively metabolized into inactive metabolites in the liver. Tapentadol-O-Glucuronide is one of the major metabolite of Tapentadol.

Enzymes CYP2C9 and CYP2C19 metabolize Tapentadol to form N-desmethyl tapentadol, whereas the enzyme CYP2D6 metabolizes it to hydroxyl tapentadol.

Tapentadol, along with its metabolite, follows a first-order elimination that is carried out by the kidney. The elimination half-life is 4 hours. The total clearance of Tapentadol from the body is about 1530±177 ml/min.


Tapentadol tablets are rapidly absorbed into the body. The oral bioavailability for a single dose is 32% due to its first-pass metabolism.

The steady-state plasma concentration is achieved in 25 to 30 hours when taken every 6 hours.

Tapentadol Brand Name

Tapentadol tablets are available under several brands or trade names.

Brand drugs are medications sold by a pharmaceutical company under that specific name which is protected by a patent.

Brand name


Aspadol 100mg

Hab Pharmaceuticals and Research Limited

Nucynta 100mg

Janssen Pharmaceuticals

Palexia 100mg

Grünenthal Ltd

A few other Tapentadol brand names are Lucynta by Lupin Laboratories Ltd, Tapcynta by Macleods Pharmaceutical Ltd, Tapster by Treatwell Biotech, and Duovolt by IPCA Laboratories Ltd.

Aspadol vs. Other Tapentadol Brands: Which is Right for You?

All Tapentadol brand medicines are formulated with the same active compound. Thus, they show similar effectiveness and potency. However, they may vary in their prices.

Tapentadol Uses And Benefits: Effective Pain Relief for Moderate to Severe Pain

Tapentadol is often prescribed when round-the-clock analgesic effect of a medication is required. It helps get relief from acute and chronic pain following musculoskeletal pain, injury, pain associated with diabetic peripheral neuropathy, and postoperative pain.

Benefits of Tapentadol

The key benefits of Tapentadol that set it apart from other opioid analgesics are-

  • Tapentadol is the first US FDA-approved centrally-acting analgesic with a dual mechanism of action.

  • Its mechanism also gives it a greater advantage over classic opioids for pain management from nociceptive pain (discomfort that arises due to tissue damage).

  • Clinical studies suggest that Tapentadol or Aspadol 100 mg has an improved side effect profile than other opioids and nonsteroid anti-inflammatory medications.

  • It is scientifically proven that Tapentadol is two to three times more potent than Tramadol.

  • The gastrointestinal side effects of Tapentadol are fewer compared to other pain medications.

Tapentadol Dosage And Formulation

Tapentadol 100 mg can be taken every 4 to 6 hours. The maximum dosage is 600 to 700 mg.

Tapentadol is available in immediate-release (IR) and extended-release (ER) formulations. The use of Tapentadol extended-release tablets or also known as tapentadol prolonged release [PR] in Europe, is approved in the United States for treating moderate to severe chronic and Neuropathic pain associated with diabetic peripheral neuropathy (DPN).

In comparison, the use of Tapentadol IR is approved for managing acute pain.

Clinical studies suggest that conversion of Tapentadol IR to ER can be done on a direct milligram to milligram basis (Tapentadol IR 100 mg to Tapentadol ER 100mg, or vice versa).

Tapentadol Dosage In Adults

Drug Formulation

Tapentadol Dosage

Maximum dosage

Dosage Interval

Tapentadol immediate release

Tapentadol 100mg

700mg per day

4 to 6 hours

Tapentadol extended release

Tapentadol 100mg (taken in two doses)

500mg per day

12 hours

Overdosing On Tapentadol Pain Medication

Do not take Tapentadol doses or its brand drugs more than 3 to 4 times daily.

The intake of Tapentadol over 700 mg daily can cause overdosing, thus increasing the risk of experiencing side effects.

Some common Tapentadol overdosing symptoms are Drowsiness, Stress, Upset stomach, Anxiety, sleep issues, Vomiting, and palpitations.

Direction Of Use Of Tapentadol 100mg

The use of Tapentadol opioid pain medication under the guidance of a physician is advisable.

  • Tapentadol can be habit-forming and cause physical and mental dependence if taken for an extended period. It is not advisable to take Tapentadol dosage for more than three continuous weeks.

  • The Tapentadol (Including Aspadol, Palexia, and Nucynta) pain medication is an oral pill and, therefore, must be administered through the mouth.

  • Take the medication without breaking and crushing.

  • Users can have a light meal about an hour before or after taking the medication.

Tapentadol 100mg Precaution And Warnings

There are several commonly asked questions about Tapentadol and its usage. The correct Tapentadol product information will ensure minimum side effects for the user and let people achieve the best benefits from the medication.

Pregnancy : Studies suggest that Tapentadol dosages can cause respiratory depression in the newborn child if taken during labor. Thus, Pregnant and lactating women should buy Tapentadol 100 mg only under the guidance of a medical professional.

Consumption of alcohol : The intake of Tapentadol dosage with alcohol is not advisable as it can result in CNS depression, causing hypotension, respiratory depression, and profound sedation.

Other medications : Taking Tapentadol 100mg with other medications can cause drug interaction, lowering the medication's efficacy and potency. Such interactions can also result in severe side effects on the user. Some of the medications that should not be taken with Tapentadol are acetylcarbromal, epinephrine, gabapentin, methadone, oxycodone, hydromorphone, phentermine, and carisoprodol.


Tapentadol Precautions

  • The use of Nucynta and Aspadol pain medication is not for children. Therefore, store the medicine away from their reach.

  • One should not pass the medication to your friends and family without consulting a doctor.

  • Store Tapentadol 100mg tablets away from moisture and direct sunlight.

  • Patients over 65 years should not buy Tapentadol 100mg without a prescription. Such people have weak metabolic activity and can slow down the action of the analgesic, taking longer for the medication to show the result.

  • Tapentadol tablets should be disposed of by first wrapping the medication on paper.

  • The administration of the Tapentadol pain medication after its expiry date is not recommendable.

Tapentadol Side Effects

The most common Tapentadol side effects contributed by the MOR agonist activity of the analgesic are dizziness, nausea, pruritis, constipation, headache, vomiting, and somnolence. The chances of side effects are less in users if the analgesic administration is correct. A few other side effects of Tapentadol 100 mg are listed below.

  • Agitation

  • Cough or fever

  • Dry mouth

  • Upset stomach

  • Excessive sweating

  • Nausea or vomiting

  • Insomnia or fatigue

Note - The Tapentadol side effects are usually very mild and not life-threatening. Users experiencing these signs must immediately discontinue the medication and consult a physician. In severe conditions (from overdosing), rush the patient to their nearest medical center.

How to Purchase Tapentadol Online in the USA: Aspadol and Other Brands

Tapentadol Hydrochloride tablets are only available under various brand names, and there is no generic version of it available in the market. So, people seeking to get Tapentadol 100 mg opioid analgesic should order one of its brand drugs. It is also a prescription drug and is not available in the USA without a doctor's consultation.

HealthNaturo is an authorized Tapentadol vendor allowing people to buy Aspadol 100mg at the best price and customer benefits. We prioritize the ease and convenience of our customers and thus offer Tapentadol without a prescription.

Placing a Tapentadol order at Healthnaturo is very easy and convenient and can be done with just a few clicks.

  • Currently, we are offering one pill package of Tapentadol 100 mg (pack of 180 pills), which is listed on the top of this product page. To place an order, click on “Buy Now.” This will take you to our cart, where you can check out after filling in the required customer details.

  • Within 24 hours of the payment, the product will be shipped to your given address.

  • You will also be notified with a tracking order within a few hours of the package being shipped.

  • We offer express shipping to all our US customers with guaranteed delivery within 5 to 7 days.

Our key features

Prescription requirements

Not required

24X7 customer assistance


Festive offers



Yes ( A refilling reminder will be sent to you letting you reorder your medication)

Extra shipping fee

No, HealthNaturo lets customers buy Tapentadol 100mg online with free shipping

First order benefits

Yes (Extra free pills on first order)

Overseas delivery time

14 to 21 days

US to US delivery

5 to 7 days

Payment options

Payment through Credit card, Debit card, Master card, and PayPal



Return or refund

Yes (contact customer support within 48 hours of receiving the package).

Tapentadol 100 mg Price Comparison: Affordable Options for Pain Management

The Tapentadol 100 mg price in USA may vary based on the pharmacy and the pill package. The Aspadol 100 mg price at Healthnaturo is about $2.7 per pill for a supply of 500 tablets.

In comparison, according to the website Drugs, the cost of Nucynta 50 mg (another Tapentadol brand drug) is $1,024 for a pack of 100 tablets. Whereas 100 mg of Nucynta is priced at $1,588 for 100 tablets.

Comparison Of Tapentadol Price With Other Opioids

The cost of all the opioid analgesics mentioned below is as per the price list on the website Drugs.

  • The cost of OxyContin 80mg oral tablets is $598 for 20 tablets.

  • 50 mg of Hydrocodone is priced at $631 for 60 capsules.

  • 30 fentanyl oral transmucosal lozenge costs about $489.

At HealthNaturo, we provide fast, secure, and discreet delivery of medicines to your doorstep. We provide US-US and overseas shipping with no extra charge. A third-party logistics is assigned to effectuate the shipment and delivery of your order.

Shipping Policy:

1. After successfully placing your order, a payment link will be sent to you within 24 hours

2. We will ship your package only after your payment and address confirmation

3. Our customers will receive a Unique tracking number on the shipment of the package

4. We will reship your package if, in any case, a part of your order is missing or damaged

Delivery time frame:

US-US delivery: 

On placing an order within US we guarantee delivery of your products within 5 to 7 business days.

Overseas delivery:

For overseas shipping, we assure delivery within 20 to 30 days from the date of shipment.

Refund policy 

Thank you for shopping at HealthNaturo!

We hope your experience with us was pleasant. If you wish to return your product, we will be happy to exchange or return the medicine, provided it meets our policy guidelines. 

Eligibility for Refunds and Exchanges

  • The products must be in the original packaging.

  • If the package appears to have been tampered with. All customers should check the package at the time of acceptance of the products.

How to return?

  • You can raise a return request within 5-7 business days from the delivery date.

  • Kindly place the request for the return of any product at [email protected].

  • Our team will get in touch with you shortly after. 

  • To initiate your return and refund, send us a clear image of the medications and their package. 

  • Depending on your preference, we will reship your medicine or initiate a refund. The amount is credited back using the original payment method. It may take 48-72hours for the amount to be reflected in the bank account.



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Tapentadol is used for moderate to severe chronic pain after consulting a doctor.

The brand names of Tapentadol are Nucynta, Tapal, Aspadol, Palexia, and Tapenta.

Tapentadol is a strong opioid that has a dual mechanism of action.

It takes about 30 minutes for Tapentadol to start working.

Tapentadol stays in the system for about 22 hours. However, it may vary in people depending on their individual factors such as metabolism, health issues, age, etc.

Tapentadol is a much more potent and stronger opioid analgesic than Tramadol. However, it is 2 to 3 times less potent than morphine. About 3.3. mg of oral Tapentadol is equivalent to 1 mg of oral morphine.

The active compound is Tapentadol. It also consists of a few inactive compounds such as Croscarmellose sodium, Microcrystalline Cellulose, Polyvinylpyrrolidone, Povidone K 30 USP, and Magnesium Stearate.

Tapentadol is a Schedule II controlled susbtance. It is a prescription and is not available over the counter.

Tapentadol may stay in the urine for 3 to 4 days. Within this period, a drug test may be able to detect its presence in the body through urine samples.